Yuan Li
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View article: Propofol suppresses breast cancer invasion: An in vitro three-dimensional cell invasion model with microfluidic technology
Propofol suppresses breast cancer invasion: An in vitro three-dimensional cell invasion model with microfluidic technology Open
The fundamental aspect of breast cancer metastasis is the infiltration of malignant cells, which can be blocked by propofol, a widely utilized anesthetic in clinical settings, as recent studies reporting. However, research utilizing three-…
View article: Genome-wide analysis of DGAT gene family in Coix lacryma jobi L. and functional characterization in yeast H1246
Genome-wide analysis of DGAT gene family in Coix lacryma jobi L. and functional characterization in yeast H1246 Open
Background Coix lacryma jobi L., a member of the Poaceae family, is a traditional Chinese medicine ingredient with a long history. In recent years, research and clinical treatment have shown that Coix lacryma jobi L. seed oil exhibits sign…
View article: Induction of Synthetic Apomixis in Two Sorghum Hybrids Enables Seed Yield and Genotype Preservation Over Multiple Generations
Induction of Synthetic Apomixis in Two Sorghum Hybrids Enables Seed Yield and Genotype Preservation Over Multiple Generations Open
Induction of apomixis, or clonal reproduction through seed, could economise commercial hybrid seed production and enable smallholder farmers to save and sow hybrid seed. Here, we demonstrate the synthetic induction of apomixis in two sorgh…
View article: Comparative analysis of biological activities and phytochemical constituents between <i>Pegaeophyton scapiflorum</i> and <i>Solms-laubachia eurycarpa</i> revealed by UPLC-Q-Orbitrap HRMS-based metabolomics
Comparative analysis of biological activities and phytochemical constituents between <i>Pegaeophyton scapiflorum</i> and <i>Solms-laubachia eurycarpa</i> revealed by UPLC-Q-Orbitrap HRMS-based metabolomics Open
Pegaeophyton scapiflorum (DHJ) and Solms-laubachia eurycarpa (KGCF) are perennial herbs from the cruciferous family. Historically, these two herbs have been documented to be effective in clearing lung heat and have been widely used clinica…
View article: Genome-wide analysis of Rf-PPR-like genes in Nicotiana tabacum and their potential roles in anther development
Genome-wide analysis of Rf-PPR-like genes in Nicotiana tabacum and their potential roles in anther development Open
Pentatricopeptide repeat ( PPR ) gene family is one of the largest gene families in higher plants. The Restoration of fertility like ( RFL ) clade of the family plays a crucial role in restoring fertility of cytoplasmic male sterility (CMS…
View article: ClPS1 gene-mediated manipulation of 2n pollen formation enables the creation of triploid seedless watermelon
ClPS1 gene-mediated manipulation of 2n pollen formation enables the creation of triploid seedless watermelon Open
Seedless watermelons are increasingly dominating the consumer market due to their convenience and high quality. However, traditional triploid watermelon breeding faces challenges such as long breeding cycles and low survival rates of tripl…
View article: Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial
Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial Open
Introduction: Combining systemic agents with hepatic arterial infusion chemotherapy (HAIC) has produced promising outcomes in advanced hepatocellular carcinoma (HCC). Raltitrexed, an antimetabolite recognized for its extended plasma half-l…
View article: The <scp>KNOX</scp> transcription factor <scp>ClSP</scp> activates <scp>ClAPRR2</scp> to regulate dark green stripe formation in watermelon
The <span>KNOX</span> transcription factor <span>ClSP</span> activates <span>ClAPRR2</span> to regulate dark green stripe formation in watermelon Open
Summary As a prominent external feature of watermelon, the stripe pattern exhibits remarkable phenotypic diversity, directly impacting commercial value through consumer preference. However, the genetic and molecular mechanisms underlying t…
View article: A multi-objective multi-factor integrated method for comprehensive luna base site selection
A multi-objective multi-factor integrated method for comprehensive luna base site selection Open
Countries are now shifting from one-off lunar exploration missions to the establishment of a lunar base for long-term sustainable surveys. The selection of a suitable site plays a crucial role in sustaining the base’s operation and facilit…
View article: Selection and optimisation reference genes for normalisation of mitochondrial gene-expression by qRT-PCR in different potato tissues and during anther development
Selection and optimisation reference genes for normalisation of mitochondrial gene-expression by qRT-PCR in different potato tissues and during anther development Open
Background Potato is the most widely grown tuber crop worldwide and a staple food in many countries: it has become the focus of many molecular breeding studies. One topical area is breeding potato seeds, especially advancing male sterile p…
View article: Advances in deciphering the mechanisms of salt tolerance in Maize
Advances in deciphering the mechanisms of salt tolerance in Maize Open
Maize (Zea mays L.) is a vital crop worldwide, serving as a cornerstone for food security, livestock feed, and biofuel production. However, its cultivation is increasingly jeopardized by environmental challenges, notably soil salinization,…
View article: Transcriptome‑wide excavation and expression pattern analysis of the NAC transcription factors in methyl jasmonate- and sodium chloride-induced Glycyrrhiza uralensis
Transcriptome‑wide excavation and expression pattern analysis of the NAC transcription factors in methyl jasmonate- and sodium chloride-induced Glycyrrhiza uralensis Open
The NAC family is among the most extensive sets of plant-exclusive transcription factors (TFs), which are crucial for various plant development and stress response processes. Although a growing number of studies have been carried out on th…
View article: Isorhamnetin Ameliorates Non-Esterified Fatty Acid-Induced Apoptosis, Lipid Accumulation, and Oxidative Stress in Bovine Endometrial Epithelial Cells via Inhibiting the MAPK Signaling Pathway
Isorhamnetin Ameliorates Non-Esterified Fatty Acid-Induced Apoptosis, Lipid Accumulation, and Oxidative Stress in Bovine Endometrial Epithelial Cells via Inhibiting the MAPK Signaling Pathway Open
High concentrations of non-esterified fatty acids (NEFA) in the blood contribute to various metabolic disorders and are linked to endometritis in dairy cows. Isorhamnetin (ISO), a flavonoid found in many plants, is known for its antioxidan…
View article: Cyclic nucleotide-gated ion channel 20 regulates melatonin-induced calcium signaling and cold tolerance in watermelon
Cyclic nucleotide-gated ion channel 20 regulates melatonin-induced calcium signaling and cold tolerance in watermelon Open
Melatonin plays a crucial role in regulating plant cold tolerance, but the mechanisms underlying signal transduction remain elusive. In this study, we discovered that overexpression of the melatonin biosynthetic gene caffeic acid O-methylt…
View article: Single‐cell analyses reveal impaired type B spermatogonia differentiation and meiotic entry in C‐Nap1‐null testes
Single‐cell analyses reveal impaired type B spermatogonia differentiation and meiotic entry in C‐Nap1‐null testes Open
Sperm development is critical for male reproductive capability; any disruption during the process of spermatogenesis will result in male infertility. In this research, we used the C‐Nap1 encoded by the gene of Cep250 knockout mouse line as…
View article: The transcription factor ClWRKY61 interacts with ClLEA55 to enhance salt tolerance in watermelon
The transcription factor ClWRKY61 interacts with ClLEA55 to enhance salt tolerance in watermelon Open
High salinity can severely inhibit the growth and development of watermelon (Citrullus lanatus L.). WRKY proteins are believed to mediate the adaptation of plants to abiotic stresses. Here, we identified the ClWRKY61 gene, which positively…
View article: Human fibroblasts from sporadic Alzheimer's disease (AD) patients show mitochondrial alterations and lysosome dysfunction
Human fibroblasts from sporadic Alzheimer's disease (AD) patients show mitochondrial alterations and lysosome dysfunction Open
Mitophagy is a mechanism that maintains mitochondrial integrity and homeostasis and is thought to promote longevity and reduce the risk of age-related neurodegenerative diseases, including Alzheimer's disease (AD). Here, we investigate the…
View article: LncRNA HOTAIR: A Novel Biomarker for the Diagnosis of Asymptomatic Carotid Artery Stenosis and Prediction of the Onset of Cerebral Ischemic Events
LncRNA HOTAIR: A Novel Biomarker for the Diagnosis of Asymptomatic Carotid Artery Stenosis and Prediction of the Onset of Cerebral Ischemic Events Open
Background Carotid artery stenosis (CAS) is a major cause of cerebral ischemic events (CIE). The purpose of the research was to reveal the diagnostic accuracy of long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) in asymp…
View article: Association of Apolipoprotein E Gene Polymorphisms with Risk of Coronary Artery Disease in a Han Chinese Population at Middle and High Altitude in China
Association of Apolipoprotein E Gene Polymorphisms with Risk of Coronary Artery Disease in a Han Chinese Population at Middle and High Altitude in China Open
Background This study aimed to assess how APOE gene polymorphisms affect the development of coronary artery disease (CAD) in the Han Chinese population at middle and high altitudes by regulating the body's lipid levels, which stimulates at…
View article: Gut-derived metabolite 3-methylxanthine enhances cisplatin-induced apoptosis via dopamine receptor D1 in a mouse model of ovarian cancer
Gut-derived metabolite 3-methylxanthine enhances cisplatin-induced apoptosis via dopamine receptor D1 in a mouse model of ovarian cancer Open
Platinum-based chemotherapy failure represents a significant challenge in the management of ovarian cancer (OC) and contributes to disease recurrence and poor prognosis. Recent studies have shed light on the involvement of the gut microbio…