Wei Xiao
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View article: Breeding and Disease Resistance Evaluation of a New Largemouth Bass (Micropterus salmoides) Strain Resistant to Largemouth Bass Virus (LMBV)
Breeding and Disease Resistance Evaluation of a New Largemouth Bass (Micropterus salmoides) Strain Resistant to Largemouth Bass Virus (LMBV) Open
Largemouth bass virus (LMBV) has caused severe impacts on the largemouth bass aquaculture industry in China. Breeding new virus-resistant strains is a fundamental strategy to address the LMBV challenge. In this study, a candidate LMBV-resi…
View article: De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors
De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors Open
View article: Extracellular Vesicles in Sarcoma: Implications for Tumor Progression and Therapy
Extracellular Vesicles in Sarcoma: Implications for Tumor Progression and Therapy Open
Sarcoma, a heterogeneous group of malignancies arising from mesenchymal tissues, poses significant clinical challenges due to its aggressive behavior, early metastasis, and resistance to conventional therapies. Recent advancements highligh…
View article: Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation
Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation Open
Damage-associated molecular patterns (DAMPs) often cause an exaggerated immune response. Fatty acid-binding protein 5 (FABP5) is traditionally considered a cytosolic protein responsible for the transport of fatty acids. However, little is …
View article: NFATc1 regulates LAG3+CD8+ T cells in the spleen of mice infected with Plasmodium yoelii NSM
NFATc1 regulates LAG3+CD8+ T cells in the spleen of mice infected with Plasmodium yoelii NSM Open
Malaria, an infectious disease caused by Plasmodium, is primarily characterized by anemia and splenomegaly. CD8 ⁺ T cells are known to play a key role in anti-malaria immunity. Lymphocyte Activation Gene 3 (LAG3), a critical immune checkpo…
View article: Intergenic Variants Upstream of GADD45b Affect Survival of Micropterus salmoides Following LMBV Exposure
Intergenic Variants Upstream of GADD45b Affect Survival of Micropterus salmoides Following LMBV Exposure Open
GADD45 (growth arrest and DNA damage inducible 45) is a crucial signaling regulator in cells and plays an important role in various biological processes, including cellular stress response, cell cycle control, DNA damage repair, apoptosis,…
View article: Evaluation of large language models in female malignancy Q&A
Evaluation of large language models in female malignancy Q&A Open
The future of artificial intelligence specialist doctors depends on foundational large language models (LLMs). However, there is currently a lack of evaluation studies on their Q&A capabilities in female malignancy. This cross-sectional st…
View article: Genetic Diversity Evaluation and Population Structure Analysis of the Genus Paphiopedilum in Guangxi: Promoting the Selection and Breeding of New Species
Genetic Diversity Evaluation and Population Structure Analysis of the Genus Paphiopedilum in Guangxi: Promoting the Selection and Breeding of New Species Open
The genus Paphiopedilum (Orchidaceae) has high ornamental value due to its long flowering period, brilliant flower color, and peculiar floral morphology. Guangxi is the center of ecological diversity of Paphiopedilum, and therefore it is u…
View article: Association of <i>AGER</i> genetic variants with chronic obstructive pulmonary disease susceptibility in Southern Chinese Han populations
Association of <i>AGER</i> genetic variants with chronic obstructive pulmonary disease susceptibility in Southern Chinese Han populations Open
Our study demonstrated that AGER genetic variants might play a protective role in the progression of COPD.
View article: <i>Streptococcus salivarius</i> -derived ilexgenin A alleviates pneumonia through the gut-lung axis
<i>Streptococcus salivarius</i> -derived ilexgenin A alleviates pneumonia through the gut-lung axis Open
The alteration of gut microbiota during critical illness is associated with adverse clinical outcomes. This connection between intestinal dysbiosis and poor outcomes has prompted the idea that restoring healthy microbial communities could …
View article: Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of laryngeal mucosa-associated lymphoid tissue lymphoma
Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of laryngeal mucosa-associated lymphoid tissue lymphoma Open
View article: Supplementary material to "Aircraft-based observation of volatile organic compounds (VOCs) over the North China Plain"
Supplementary material to "Aircraft-based observation of volatile organic compounds (VOCs) over the North China Plain" Open
View article: Effect of bariatric surgery on glycemic and metabolic outcomes in people with obesity and type 2 diabetes mellitus: a systematic review, meta-analysis, and meta-evidence of 39 studies
Effect of bariatric surgery on glycemic and metabolic outcomes in people with obesity and type 2 diabetes mellitus: a systematic review, meta-analysis, and meta-evidence of 39 studies Open
Background Bariatric surgery has become a widely utilized therapeutic approach for obesity management and glycemic regulation in individuals with type 2 diabetes mellitus (T2DM). This meta-analysis examines the effects of bariatric surgery…
View article: Potential risk of dipterocarps in the marginal Asian rainforests: low population size and high genomic erosion
Potential risk of dipterocarps in the marginal Asian rainforests: low population size and high genomic erosion Open
View article: Evaluation of DeepSeek-R1 and its distilled models for performance and cost efficiency in oncology
Evaluation of DeepSeek-R1 and its distilled models for performance and cost efficiency in oncology Open
Introduction: Malignant tumors represent a significant public health threat, and the integration of artificial intelligence in health care is increasingly becoming a priority. Many oncology institutions are already considering the use of D…
View article: P-104 Elevated levels of reactive oxygen species in sperm impact embryo development in intracytoplasmic sperm injection but not in conventional vitro fertilization cycles
P-104 Elevated levels of reactive oxygen species in sperm impact embryo development in intracytoplasmic sperm injection but not in conventional vitro fertilization cycles Open
Study question Does sperm reactive oxygen species (ROS) influence fertilization and embryo development parameters in conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles? Summary answer Elevated leve…
View article: Foundation models and intelligent decision-making: Progress, challenges, and perspectives
Foundation models and intelligent decision-making: Progress, challenges, and perspectives Open
View article: Comparison of accuracy in C1–C2 pedicle screw placement: O-arm, 3D guides, and C-arm fluoroscopy
Comparison of accuracy in C1–C2 pedicle screw placement: O-arm, 3D guides, and C-arm fluoroscopy Open
To evaluate the accuracy and safety of C1-C2 pedicle screw placement using O-arm navigation, individualized 3D-printed guides, and C-arm fluoroscopy. Clinical data of 47 patients who underwent C1-C2 spinal fixation surgery at our instituti…
View article: Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs
Desulfovibrio vulgaris exacerbates sepsis by inducing inflammation and oxidative stress in multiple organs Open
Introduction Sepsis is a life-threatening condition that often leads to organ dysfunction and systemic inflammation, with gut microbiota dysbiosis playing a crucial role in its pathogenesis. The role of Desulfovibrio vulgaris ( D. vulgaris…
View article: Dietary iron intake is nonlinearly associated with the risk of diabetic retinopathy in adults with type 2 diabetes
Dietary iron intake is nonlinearly associated with the risk of diabetic retinopathy in adults with type 2 diabetes Open
Dietary iron intake was nonlinearly negatively associated with the prevalence of DR and VTDR, showing protective effect against retinopathy of medium-high iron intake in T2D patients. Such associations significantly vary by multiple factor…
View article: Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis
Tissue-wide profiling of human lungs reveals spatial sequestration of macrophages in tuberculosis Open
The immune response to human tuberculosis (TB), particularly in the context of complex lung pathology, remains incompletely understood. Here, we employed whole-slide spatial proteomics to map immune cell organization in TB-affected human l…
View article: Comparison of Accuracy in C1-C2 Pedicle Screw Placement: O-arm, 3D Guides, and C-arm Fluoroscopy
Comparison of Accuracy in C1-C2 Pedicle Screw Placement: O-arm, 3D Guides, and C-arm Fluoroscopy Open
Objective: To evaluate the accuracy and safety of C1-C2 pedicle screw placement using O-arm navigation, individualized 3D-printed guides, and C-arm fluoroscopy. Methods: Clinical data of 47 patients who underwent C1-C2 spinal fixation surg…
View article: Dietary iron intake is nonlinearly associated with the risk of diabetic retinopathy in adults with type 2 diabetes
Dietary iron intake is nonlinearly associated with the risk of diabetic retinopathy in adults with type 2 diabetes Open
Objective: To elucidate the association between dietary iron intake and diabetic retinopathy (DR) in type 2 diabetes (T2D) patients. Methods: Participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2008 aged ov…
View article: Association between exposure to per- and polyfluoroalkyl substances and kidney function: a population study
Association between exposure to per- and polyfluoroalkyl substances and kidney function: a population study Open
Background The relationship between per- and polyfluoroalkyl substances (PFAS) and kidney function markers remains uncertain. Methods We used PFAS detection data from 5,947 adults in NHANES 2005–2012. We employed multivariable linear regre…
View article: Identification of Elite Agronomic Traits Using Chromosome Arm Substitution Lines of Triticum dicoccoides in the Background of Common Wheat
Identification of Elite Agronomic Traits Using Chromosome Arm Substitution Lines of Triticum dicoccoides in the Background of Common Wheat Open
To effectively mine and utilize the valuable genes of wild emmer wheat (Triticum dicoccoides, 2n = 4x = 28, AABB), this study conducted an investigation of agronomic traits using two sets of chromosome arm substitution lines (CASLs) of wil…
View article: Modelling analysis of dietary behaviors and oral health status to assess the impact on the mental well-being of elderly individuals: a cross-sectional survey study
Modelling analysis of dietary behaviors and oral health status to assess the impact on the mental well-being of elderly individuals: a cross-sectional survey study Open
Background and objective Global aging is becoming a pressing concern, with a heightened focus on the mental well-being of the elderly population. The mental health of the elderly is influenced by a plethora of factors such as physical heal…
View article: Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential
Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential Open
Scorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases. This review provides a compre…
View article: Efficacy and safety of pharmacological and non-pharmacological therapies in Lennox-Gastaut syndrome: a systematic review and network meta-analysis
Efficacy and safety of pharmacological and non-pharmacological therapies in Lennox-Gastaut syndrome: a systematic review and network meta-analysis Open
Objective This study aimed to evaluate the efficacy and safety of antiepileptic drugs and non-pharmacological treatments in patients with Lennox-Gastaut syndrome (LGS). Methods We conducted a systematic search of the PubMed, Embase, Cochra…
View article: Exploring Molecular Pathways in Exercise-Induced Recovery from Traumatic Brain Injury
Exploring Molecular Pathways in Exercise-Induced Recovery from Traumatic Brain Injury Open
Traumatic brain injury (TBI) is functional damage or brain injury due to external forces and is a leading cause of death and disability in children and adults. It causes disruption of the blood-brain barrier (BBB), infiltration of peripher…
View article: The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment
The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment Open