Lieping Chen
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View article: Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance 2475
Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance 2475 Open
Description Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA sequencing data from multiple human cancer types and the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal …
View article: Why has immune “checkpoint” therapy failed in most clinical trials?
Why has immune “checkpoint” therapy failed in most clinical trials? Open
Cancer immunotherapy targeting the PD-1/PD-L1 pathway has demonstrated efficacy across a range of common solid tumors and some hematopoietic malignancies. Despite these groundbreaking successes, the clinical development of other ‘checkpoin…
View article: Sex-based differences in CEACAM5 expression in lung cancer
Sex-based differences in CEACAM5 expression in lung cancer Open
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is expressed in 20-25% of non-small cell lung cancer (NSCLC) and there is interest in CEACAM5 as a biomarker given its potential for blood-based detection and investigatio…
View article: Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer
Is Lipid Metabolism of Value in Cancer Research and Treatment? Part I- Lipid Metabolism in Cancer Open
For either healthy or diseased organisms, lipids are key components for cellular membranes; they play important roles in numerous cellular processes including cell growth, proliferation, differentiation, energy storage and signaling. Exerc…
View article: Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer
Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer Open
Acute inflammation is the body’s first defense in response to pathogens or injury that is partially governed by a novel genus of endogenous lipid mediators that orchestrate the resolution of inflammation, coined specialized pro-resolving m…
View article: Supplementary Material for: Blood eosinophil count and its determinants in a Chinese population-based cohort
Supplementary Material for: Blood eosinophil count and its determinants in a Chinese population-based cohort Open
Introduction: Blood eosinophil count has been shown markedly variable across different populations. However, its distribution in Chinese general population remains unclear. We aimed to investigate blood eosinophil count and its determinant…
View article: PD-1H/VISTA mediates immune evasion in acute myeloid leukemia
PD-1H/VISTA mediates immune evasion in acute myeloid leukemia Open
Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well as modern therapeutics, such as targeted therapy and immunotherapy, including anti-programmed cell death protein…
View article: Cardiac fibroblasts-mtExosomes-macrophages axis aggravates ventricular remodeling after acute myocardial infarction
Cardiac fibroblasts-mtExosomes-macrophages axis aggravates ventricular remodeling after acute myocardial infarction Open
Background Intercellular communication between cardiac fibroblasts (CFs) and macrophages plays an important role in the progression of ventricular remodeling after acute myocardial infarction (AMI). Following intense oxidative stress, acti…
View article: O041 Exploring the Landscape of Sleep Data Resources: A Literature Survey
O041 Exploring the Landscape of Sleep Data Resources: A Literature Survey Open
Introduction The complex physiologic interdependencies of sleep make sleep medicine a data-rich discipline. Emerging big data approaches hold promise for novel discoveries, however, scholars have suggested these advances may be hindered by…
View article: <scp>Anti‐Siglec</scp>‐15 Antibody Prevents Marked Bone Loss after Acute Spinal Cord Injury‐Induced Immobilization in Rats
<span>Anti‐Siglec</span>‐15 Antibody Prevents Marked Bone Loss after Acute Spinal Cord Injury‐Induced Immobilization in Rats Open
Rapid and extensive sublesional bone loss after spinal cord injury (SCI) is a difficult medical problem that has been refractory to available interventions except the antiresorptive agent denosumab (DMAB). While DMAB has shown some efficac…
View article: ACTIVITY AND SAFETY OF PRECLINICAL AND A PHASE 1 STUDY OF PURINOSTAT MESYLATE, A UNIQUELY POTENT AND SELECTIVE HDAC I/IIB INHIBITOR IN RELAPSED OR REFRACTORY LYMPHOMA
ACTIVITY AND SAFETY OF PRECLINICAL AND A PHASE 1 STUDY OF PURINOSTAT MESYLATE, A UNIQUELY POTENT AND SELECTIVE HDAC I/IIB INHIBITOR IN RELAPSED OR REFRACTORY LYMPHOMA Open
Introduction: Purinostat Mesylate (PM) is a uniquely potent and selective HDAC I/IIb inhibitor. This study evaluated the efficacy and safety of PM in preclinical studies and phase 1 clinical trial for the treatment of relapsed or refractor…
View article: OP0266 HIGHER RISK OF LUPUS MORTALITY IN URBANIZED THAN IN LESS-URBANIZED NEIGHBORHOODS
OP0266 HIGHER RISK OF LUPUS MORTALITY IN URBANIZED THAN IN LESS-URBANIZED NEIGHBORHOODS Open
Background Lupus mortality differs by sex, race/ethnicity, and geographical region in the United States, with females, blacks, and residents of the South census region experiencing higher age-standardized mortality rates relative to their …