Tao Han
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View article: Magnetic resonance imaging fractal analysis of O(6)-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase wild-type glioblastoma
Magnetic resonance imaging fractal analysis of O(6)-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase wild-type glioblastoma Open
The preoperative fractal analysis is a reliable predictive tool for MGMT promoter methylation status in patients with GBM.
View article: Mediterranean diet, metabolic signature, genetic predisposition, and risk of rheumatoid arthritis: a large-scale population-based prospective cohort study
Mediterranean diet, metabolic signature, genetic predisposition, and risk of rheumatoid arthritis: a large-scale population-based prospective cohort study Open
We identified a robust metabolic signature reflecting the metabolic response to the MED diet. This signature was inversely associated with RA risk and partially mitigated the genetic susceptibility to RA. These findings highlight the poten…
View article: Utilising a two-dimensional action space as the basis for the PPO algorithm, job shops can jointly schedule AGVs and machinery
Utilising a two-dimensional action space as the basis for the PPO algorithm, job shops can jointly schedule AGVs and machinery Open
For the joint scheduling problem of AGVs and machines in job shops, traditional scheduling methods are often constrained and difficult to adapt to complex production environments and demand changes. For this reason, this paper proposes a P…
View article: Integrated Modeling of Composition-Resolved Source Apportionment and Dynamic Projection for Ozone Pollution in Datong
Integrated Modeling of Composition-Resolved Source Apportionment and Dynamic Projection for Ozone Pollution in Datong Open
Growing ozone (O3) pollution in industrial cities urgently requires in-depth mechanistic research. This study utilized multi-year observational data from Datong City, China, from 2020 to 2024, integrating time trend diagnostics, correlatio…
View article: Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy
Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy Open
Immunotherapy is a breakthrough in the treatment of triple-negative breast cancer (TNBC), although it is only effective in a portion of patients. Our clinical studies find that pathological elevated level of reactive oxygen species (ROS) a…
View article: Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue
Application value of indocyanine green lymphography in the management of stage I/IIA microcystic lymphatic malformation of the tongue Open
This study was retrospectively registered on clinicaltrials.gov: NCT06755905, date of registration: January 20, 2025.
View article: A real-world study on the efficacy and safety of low-dose PD-1 monoclonal antibody alone or in combination as the first-line treatment for advanced non-small cell lung cancer
A real-world study on the efficacy and safety of low-dose PD-1 monoclonal antibody alone or in combination as the first-line treatment for advanced non-small cell lung cancer Open
Background In clinical practice, patients with non-small cell lung cancer (NSCLC) often receive low-dose programmed death-1 (PD-1) monoclonal antibodies due to physical or financial limitations. However, the efficacy and safety of low-dose…
View article: Geriatric-led transitional care for older adults discharged from the emergency department: impact on hospital readmissions and disability. Protocol for the controlled prospective quasi-experimental study LASUITE
Geriatric-led transitional care for older adults discharged from the emergency department: impact on hospital readmissions and disability. Protocol for the controlled prospective quasi-experimental study LASUITE Open
The study protocol was registered on ClinicalTrial.org (ID NCT05814328 Date 20230414).
View article: VQLTI: Long-Term Tropical Cyclone Intensity Forecasting with Physical Constraints
VQLTI: Long-Term Tropical Cyclone Intensity Forecasting with Physical Constraints Open
Tropical cyclone (TC) intensity forecasting is crucial for early disaster warning and emergency decision-making. Numerous researchers have explored deep-learning methods to address computational and post-processing issues in operational fo…
View article: MicroRNA-126: From biology to therapeutics
MicroRNA-126: From biology to therapeutics Open
MicroRNA-126 (miR-126) has emerged as one of the most extensively studied microRNAs in the context of human diseases, particularly in vascular disorders and cancer. Its high degree of conservation across vertebrates underscores its evoluti…
View article: Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial
Efficacy and safety of GLS4 with entecavir vs entecavir alone in chronic hepatitis B patients: A multicenter clinical trial Open
The primary analysis at week 48 showed that the antiviral efficacy of GLS4/RTV with ETV was clearly superior to that of ETV monotherapy. GLS4/RTV with ETV was well tolerated; further studies evaluating its safety and efficacy are ongoing. …
View article: Knowledge, attitude, and practice of cardiac rehabilitation among patients after coronary artery stenting
Knowledge, attitude, and practice of cardiac rehabilitation among patients after coronary artery stenting Open
Stent implantation effectively relieves coronary artery disease (CAD), and post-surgery cardiac rehabilitation is essential for prognosis. This study aimed to investigate the knowledge, attitude, and practice (KAP) of patients undergoing c…
View article: VQLTI: Long-Term Tropical Cyclone Intensity Forecasting with Physical Constraints
VQLTI: Long-Term Tropical Cyclone Intensity Forecasting with Physical Constraints Open
Tropical cyclone (TC) intensity forecasting is crucial for early disaster warning and emergency decision-making. Numerous researchers have explored deep-learning methods to address computational and post-processing issues in operational fo…
View article: Study on the Biofilm Kinetics in Micro-Electrolysis Biological Reactors
Study on the Biofilm Kinetics in Micro-Electrolysis Biological Reactors Open
The kinetic study of micro-electrolysis biotechnology not only determines the removal efficiency of a micro-electrolysis process but also influences the optimal design of a system. This paper investigates the relationship between electric …
View article: The origin and flow of a Bronze Age urban population in ancient China: an investigation based on the craniometric study
The origin and flow of a Bronze Age urban population in ancient China: an investigation based on the craniometric study Open
The Dahekou cemetery in southern Shanxi Province is an important archaeological site dating to the Western Zhou period (1046 BC-771 BC). Based on the inscriptions on funerary artefacts, the cemetery is believed to belong to a local enfeoff…
View article: A machine learning approach to correct imaging distortions in swept-source optical coherence tomography
A machine learning approach to correct imaging distortions in swept-source optical coherence tomography Open
The inevitable distortions in optical coherence tomography (OCT) imaging often lead to mismatches between the imaging space and the real space, significantly affecting measurement accuracy. To address this issue, this study proposes a mach…
View article: Exploration of Quantum Chemistry Methods to Explain Mechanism of Mechanochemical Degradation of Typical Organic Pollutants
Exploration of Quantum Chemistry Methods to Explain Mechanism of Mechanochemical Degradation of Typical Organic Pollutants Open
The high-efficiency ball milling treatment technology primarily combines the excitation of oxidation processes with high-speed physical collisions, thereby promoting the reaction processes and enhancing the degradation effectiveness of mat…
View article: Existence and asymptotic behavior of normalized solutions for fourth‐order equations of Kirchhoff type
Existence and asymptotic behavior of normalized solutions for fourth‐order equations of Kirchhoff type Open
In this paper, we consider the following fourth‐order equation of Kirchhoff type under the normalized constraint , where are constants, and is a Lagrange multiplier. Firstly, we obtain the existence of ground state solutions for or with . …
View article: Nomogram of magnetic resonance imaging (MRI) histogram analysis to predict telomerase reverse transcriptase promoter mutation status in glioblastoma
Nomogram of magnetic resonance imaging (MRI) histogram analysis to predict telomerase reverse transcriptase promoter mutation status in glioblastoma Open
T1C histogram parameters can be used to evaluate pTERT mutations status in GBM. A nomogram based on conventional MRI features and T1C histogram parameters is a reliable tool for the pTERT mutation status, allowing for non-invasive radiolog…
View article: MRI features and tumor-infiltrating CD8 + T cells-based nomogram for predicting meningioma recurrence risk
MRI features and tumor-infiltrating CD8 + T cells-based nomogram for predicting meningioma recurrence risk Open
Objective This study was based on MRI features and number of tumor-infiltrating CD8 + T cells in post-operative pathology, in predicting meningioma recurrence risk. Methods Clinical, pathological, and imaging data of 102 patients with surg…
View article: Role of maternal–fetal immune tolerance in the establishment and maintenance of pregnancy
Role of maternal–fetal immune tolerance in the establishment and maintenance of pregnancy Open
Normal pregnancy is a contradictory and complicated physiological process. Although the fetus carries the human leukocyte antigen (HLA) inherited from the paternal line, it does not cause maternal immune rejection. As the only exception to…
View article: Seasonality in northern South China Sea during the late Holocene
Seasonality in northern South China Sea during the late Holocene Open
The annual temperature cycle is an important component of the Earth’s climate system. Here, the multiple snapshots sea surface temperature (SST) seasonality during past ~1600 years of northern South China Sea were reconstructed using…
View article: The Pacific Decadal Oscillation modulates global temperature trends since the mid-18th century
The Pacific Decadal Oscillation modulates global temperature trends since the mid-18th century Open
The Pacific Decadal Oscillation (PDO) plays a crucial role in global decadal climate variability. However, large discrepancies persist in the determination of pre-industrial PDO variability derived from terrestrial proxy records. Here we r…
View article: Differences in the attitudes towards resuscitation of extremely premature infants between neonatologists and obstetricians: a survey study in China
Differences in the attitudes towards resuscitation of extremely premature infants between neonatologists and obstetricians: a survey study in China Open
Objectives Neonatologists and obstetricians are crucial decision-makers regarding the resuscitation of extremely preterm infants (EPIs). However, there is a scarcity of research regarding the differing perspectives on EPI resuscitation bet…
View article: Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer? Open
Hepatocellular carcinoma (HCC), one of the most prevalent forms of cancer worldwide, presents a significant global healthcare challenge. Cancer stem cells (CSCs), which can influence neighboring non-CSCs, are believed to play a crucial rol…