Explanipedia

Understanding the Biomechanics Following Ballistic Cranial Trauma by Human Cranial Biomaterials Open

Akanae Chattrairat, Everson Kandare, Sontipee Aimmanee, Phuong H.L. Tran, Raj Das · 2024

Runs of Extremes of Observables on Dynamical Systems and Applications Open

Meagan Carney, Mark Holland, Matthew Nicol, Phuong H.L. Tran · 2023

We use extreme value theory to estimate the probability of successive exceedances of a threshold value of a time-series of an observable on several classes of chaotic dynamical systems. The observables have either a Fréchet (fat-tailed) or…

Development of Blueberry-Derived Extracellular Nanovesicles for Immunomodulatory Therapy Open

Tuong Ngoc-Gia Nguyen, Cuong Viet Pham, Rocky Chowdhury, Shweta Patel, Satendra Kumar Jaysawal , et al. · 2023

Over the past decade, there has been a significant expansion in the development of plant-derived extracellular nanovesicles (EVs) as an effective drug delivery system for precision therapy. However, the lack of effective methods for the is…

Survival After Resection for Epidermoid Cyst-originated Squamous Cell Carcinoma of the Liver: Case Report and Review of the Literature Open

Khai Viet Ninh, Đang Hai, Tuan K.A. Hoang, Phuong H.L. Tran, Lanh S Nguyen , et al. · 2022

The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells Open

Wang Yin, Dongxi Xiang, Tao Wang, Yumei Zhang, Cuong Viet Pham , et al. · 2021

Two ATP-binding cassette transporters, ABCB1/MDR1 and ABCG2/BCRP, are considered the most critical determinants for chemoresistance in hepatocellular carcinoma. However, their roles in the chemoresistance in liver cancer stem cells remain …

Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins Open

Phuong H.L. Tran, Thao T.D. Tran · 2021

Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of ag…

Author Correction: Aptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells Open

Hadi AlShamaileh, Tao Wang, Dongxi Xiang, Yin Wang, Phuong H.L. Tran , et al. · 2020

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs Open

Thao T.D. Tran, Phuong H.L. Tran · 2020

Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will a…

Lead Compounds in the Context of Extracellular Vesicle Research Open

Thao T.D. Tran, Phuong H.L. Tran · 2020

Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs du…

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs Open

Thao T.D. Tran, Phuong H.L. Tran · 2020

In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many …

The relationship between mucoadhesive polymers and surface coating in tablets for the controlled colonic delivery of a poorly water-soluble drug Open

Quoc Thang Phan, Phuong H.L. Tran, Thao T.D. Tran · 2020

Shear Stress-Dependent Targeting Efficiency Using Self-Assembled Gelatin–Oleic Nanoparticles in a Biomimetic Microfluidic System Open

Taehee Kang, Chulhun Park, Nileshkumar Meghani, Thao T.D. Tran, Phuong H.L. Tran , et al. · 2020

Cellular properties and microenvironments, as well as the characteristics of nanoparticles (NPs), affect the cellular uptake and cytotoxic effects of drug-loaded NPs. Since there is fluid flow in the human blood system, fluid flow also aff…

Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics Open

Dongbin Yang, Weihong Zhang, Huanyun Zhang, Fengqiu Zhang, Lanmei Chen , et al. · 2020

Exosomes are small extracellular vesicles with diameters of 30-150 nm. In both physiological and pathological conditions, nearly all types of cells can release exosomes, which play important roles in cell communication and epigenetic regul…

Assessing Spatiotemporal Drought Dynamics and Its Related Environmental Issues in the Mekong River Delta Open

Thuong V. Tran, Duy X. Tran, Soe W. Myint, P. Carmona, Duan Dinh Ho , et al. · 2019

Drought is a major natural disaster that creates a negative impact on socio-economic development and environment. Drought indices are typically applied to characterize drought events in a meaningful way. This study aims at examining variat…

Development of the Modified Ocimum gratissimum Seeds for Orally Disintegrating Tablets Open

Yen N.T. Dang, Phuong H.L. Tran, Thao T.D. Tran · 2019

Background: Natural materials have been encouraged in controlled drug release and improved drug bioavailability. Objective: This study aimed to develop a modification process for the use of a natural material, Ocimum gratissimum seeds (OGS…

Exosomes and Nanoengineering: A Match Made for Precision Therapeutics Open

Phuong H.L. Tran, Dongxi Xiang, Thao T.D. Tran, Wang Yin, Yumei Zhang , et al. · 2019

Targeted exosomal delivery systems for precision nanomedicine attract wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes are naturally derived 50–150 nm nanovesicles that play impor…

Development of solid dispersion lipid nanoparticles for improving skin delivery Open

Duong Pham, Phuong H.L. Tran, Thao T.D. Tran · 2019

Nanoconjugation and Encapsulation Strategies for Improving Drug Delivery and Therapeutic Efficacy of Poorly Water-Soluble Drugs Open

Thao T.D. Tran, Phuong H.L. Tran · 2019

Nanoconjugations have been demonstrated to be a dominant strategy for drug delivery and biomedical applications. In this review, we intend to describe several strategies for drug formulation, especially to improve the bioavailability of po…

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery Open

Thao T.D. Tran, Phuong H.L. Tran · 2019

Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potent…

Investigation of Crystallization and Salt Formation of Poorly Water-Soluble Telmisartan for Enhanced Solubility Open

Chulhun Park, Nileshkumar Meghani, Yongkwan Shin, Euichaul Oh, Jun-Bom Park , et al. · 2019

The crystal changes and salt formation of poorly water-soluble telmisartan (TEL) in various solvents were investigated for enhanced solubility, stability and crystallinity. Polymorphic behaviors of TEL were characterized by dispersing in d…

Aptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells Open

Hadi AlShamaileh, Tao Wang, Dongxi Xiang, Wang Yin, Phuong H.L. Tran , et al. · 2017

Transforming doxorubicin into a cancer stem cell killer via EpCAM aptamer-mediated delivery Open

Dongxi Xiang, Sarah Shigdar, Andrew G. D. Bean, Matthew P. Bruce, Wenrong Yang , et al. · 2017

Chemotherapy-resistant cancer stem cells (CSCs) are a major obstacle to the effective treatment of many forms of cancer. To overcome CSC chemo-resistance, we developed a novel system by conjugating a CSC-targeting EpCAM aptamer with doxoru…

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