Lieven Declercq
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Correction to Discovery of <i>N</i>-(4-[<sup>18</sup>F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer Open
status: Published
View article: TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study
TSPO Versus P2X7 as a Target for Neuroinflammation: An In Vitro and In Vivo Study Open
Neuroinflammation is important in amyotrophic lateral sclerosis (ALS). The P2X7 receptor (P2X7R) is a promising target for neuroinflammation. The objective of this study was to compare 18F-DPA714, a second-generation translocator protein t…
Preclinical Evaluation of<sup>18</sup>F-JNJ64349311, a Novel PET Tracer for Tau Imaging Open
In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥500×) in vitro selectivity for tau over β-amyloid, in comparison with the benchma…
Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT Open
Clinical trials aiming to develop disease-altering drugs for Alzheimer's disease (AD), a neurodegenerative disorder with devastating consequences, are failing at an alarming rate. Poorly defined inclusion-and outcome criteria, due to a lim…
View article: Comparison of New Tau PET-Tracer Candidates With [<sup>18</sup>F]T808 and [<sup>18</sup>F]T807
Comparison of New Tau PET-Tracer Candidates With [<sup>18</sup>F]T808 and [<sup>18</sup>F]T807 Open
Early clinical results of two tau tracers, [ 18 F]T808 and [ 18 F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acqu…