Lieza G. Exalto
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View article: Revisiting the Montreal Cognitive Assessment in a European cohort of elderly living with type 2 diabetes
Revisiting the Montreal Cognitive Assessment in a European cohort of elderly living with type 2 diabetes Open
Background Individuals with type 2 diabetes have an increased risk of developing both vascular and Alzheimer's dementia. Objective This prospective cross-sectional study assessed the screening ability of the standard Montreal Cognitive Ass…
View article: Finding the Clinical Traces of Cognitive Impairment in Patients with Heart Failure: A Natural Language Processing Study of Clinical Letters from Routine Care
Finding the Clinical Traces of Cognitive Impairment in Patients with Heart Failure: A Natural Language Processing Study of Clinical Letters from Routine Care Open
Cognitive impairment is common in patients with heart failure, but to which extent cognitive complaints are evaluated and listed in clinical practice is unknown. Therefore, this study aims to identify whether cognitive complaints are liste…
View article: Sex differences in cognitive functioning in patients with heart failure
Sex differences in cognitive functioning in patients with heart failure Open
Women and men with HF differ in cognitive functioning, predominantly in memory functioning, these differences were related to some sex differences in HF-characteristics and vascular brain injury, but not to all.
View article: Sex-Based Analysis of Treatment, Time Metrics, and Outcomes in Acute Ischemic Stroke Patients Treated in the Netherlands
Sex-Based Analysis of Treatment, Time Metrics, and Outcomes in Acute Ischemic Stroke Patients Treated in the Netherlands Open
Introduction: Sex disparities in stroke treatment have gained increasing interest, especially since women have worse post-stroke functional outcomes compared with men. Existing studies provide conflicting evidence, with some indicating wom…
View article: Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients
Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients Open
Introduction White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating cognitive health. However, WMH volume alone does not fully account for the ext…
View article: Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study
Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study Open
Background and purpose Risk factors for stroke differ between women and men in general populations. However, little is known about sex differences in secondary prevention. We investigated if sex interacted with modifiable risk factors for …
View article: Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients
Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients Open
INTRODUCTION White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid‐β 1‐…
View article: Alzheimer’s Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis
Alzheimer’s Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis Open
Background: We hypothesize that Alzheimer’s disease (AD)-related pathology may accelerate cognitive decline in patients with cardiovascular diseases. Objective: To investigate the association between blood-based biomarkers of AD, astrocyte…
View article: Identifying factors affecting resilience in atrophy-based subtypes of vascular cognitive impairment
Identifying factors affecting resilience in atrophy-based subtypes of vascular cognitive impairment Open
Introduction: Vascular cognitive impairment (VCI) is heterogeneous in brain atrophy patterns, clinical symptoms, and possibly in the factors affecting resilience to symptoms. The objective of this study was to investigate the heterogeneity…
View article: The relationship between enlarged perivascular spaces and clinical outcomes in patients with vascular cognitive impairment
The relationship between enlarged perivascular spaces and clinical outcomes in patients with vascular cognitive impairment Open
Introduction: Enlarged perivascular spaces (ePVS) on brain MRI are common in people with impaired cognition and have been linked to both small vessel disease (SVD) and Alzheimer's disease (AD). However, the predictive value of ePVS for cli…
View article: Sex-specific risk of impaired vascular cognitive impairment in elderly patients with diabetes
Sex-specific risk of impaired vascular cognitive impairment in elderly patients with diabetes Open
Introduction: Globally, women with dementia have a higher disease burden than men with dementia. In addition, women with diabetes especially are at higher risk for cognitive impairment and dementia compared to men with diabetes. Difference…
View article: Sexual dimorphism in peripheral blood cell characteristics relate to success of endovascular thrombectomy in acute ischemic stroke
Sexual dimorphism in peripheral blood cell characteristics relate to success of endovascular thrombectomy in acute ischemic stroke Open
Introduction The success of endovascular thrombectomy (EVT) in acute ischemic stroke is related to stroke etiology and clot composition. The latter two may differ between women and men. An improved understanding of sex differences in EVT s…
View article: Structural and metabolic retinal changes associated with mild cognitive impairment in type 2 diabetes
Structural and metabolic retinal changes associated with mild cognitive impairment in type 2 diabetes Open
Type 2 diabetes is associated with cognitive impairment and a twofold increased risk of dementia compared to age-matched individuals without diabetes. Given that the eye and the brain share similar embryologic origin and anatomical feature…
View article: Structural and Metabolic Retinal Changes Associated With Mild Cognitive Impairment in Type 2 Diabetes
Structural and Metabolic Retinal Changes Associated With Mild Cognitive Impairment in Type 2 Diabetes Open
Type 2 diabetes is associated with cognitive impairment and a twofold increased risk of dementia compared with age-matched individuals without diabetes. Given that the eye and the brain share similar embryologic origin and anatomical featu…
View article: Structural and metabolic retinal changes associated with mild cognitive impairment in type 2 diabetes
Structural and metabolic retinal changes associated with mild cognitive impairment in type 2 diabetes Open
Type 2 diabetes is associated with cognitive impairment and a twofold increased risk of dementia compared to age-matched individuals without diabetes. Given that the eye and the brain share similar embryologic origin and anatomical feature…
View article: Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke
Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke Open
BACKGROUND: Poststroke cognitive impairment (PSCI) occurs in about half of stroke survivors. Cumulative evidence indicates that functional outcomes of stroke are worse in women than men. Yet it is unknown whether the occurrence and charact…
View article: Spatial distributions of white matter hyperintensities on brain MRI: A pooled analysis of individual participant data from 11 memory clinic cohorts
Spatial distributions of white matter hyperintensities on brain MRI: A pooled analysis of individual participant data from 11 memory clinic cohorts Open
Aggregating data from several memory clinic cohorts, we provide a detailed 3D map of WMH lesion distribution frequencies, that informs on common as well as rare localizations. The use of data-driven analysis with LOF can be used to identif…
View article: Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion‐symptom mapping study in 3525 memory clinic patients
Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion‐symptom mapping study in 3525 memory clinic patients Open
Introduction Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study. Method…
View article: Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease related brain injury
Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease related brain injury Open
In cerebral small vessel disease (cSVD), whole brain MRI markers of cSVD-related brain injury explain limited variance to support individualized prediction. Here, we investigate whether considering abnormalities in brain tracts by integrat…
View article: Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population
Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population Open
Introduction Globally, women with dementia have a higher disease burden than men with dementia. In addition, women with diabetes especially are at higher risk for cognitive impairment and dementia compared to men with diabetes. Differences…
View article: Call to Action for Enhanced Equity: Racial/Ethnic Diversity and Sex Differences in Stroke Symptoms
Call to Action for Enhanced Equity: Racial/Ethnic Diversity and Sex Differences in Stroke Symptoms Open
Background Fundamental aspects of human identity may play a role in the presentation of stroke symptoms and, consequently, stroke recognition. Strokes must be recognized and treated expeditiously, as delays result in poorer outcomes. It is…