Explanipedia

AI driven quantitative analysis of meibomian glands in children and adolescents: a benchmark dataset study Open

Li Li, Kunhong Xiao, Kunfeng Lai, Taichen Lai, Yujie Wang , et al. · 2025

Current status and solutions for AI ethics in ophthalmology: a bibliometric analysis Open

Xinwei Chen, Yahan Yang, Dongyuan Yun, Ruixin Wang, Yu‐Chun Lin , et al. · 2025

Ophthalmology, an early adopter of medical artificial intelligence (AI), has made significant advancements, but ethical discussions limited. This bibliometric analysis reviewed 498 publications from Web of Science and Scopus (2000-2023) to…

Development and multicenter validation of an AI driven model for quantitative meibomian gland evaluation Open

Li Li, Kunhong Xiao, Taichen Lai, Kunfeng Lai, Jiawen Lin , et al. · 2025

TFOS DEWS III: Diagnostic Methodology Open

James S. Wolffsohn, Javier Benítez del Castillo Sánchez, Denise Loya-García, Takenori Inomata, Geetha Iyar , et al. · 2025

A standard approach to the diagnosis of dry eye disease across eye care practitioners is critical to reassuring the patient, providing consistency between practitioners and informing governments as to the true prevalence and resulting heal…

Effect of reaction styles theory-based interventions on relieving fatigue of patients with systemic lupus erythematosus Open

Yuwei LI, Wei Song, S C Wang, Bina Habibi, Lingyi Liang , et al. · 2025

Objective This study aims to investigate the effect of interventions based on response styles theory on relieving fatigue in patients with systemic lupus erythematosus. Methods A total of 72 SLE patients admitted to the Rheumatology and Im…

Association between long-term green space exposure and dry eye in China Open

Weijing Cheng, Hsing‐Chien Wu, Zhenyu Wang, Lingyi Liang · 2025

Our findings suggest an association between green space exposure and diagnosis of dry eye and tear meniscus, offering novel insights into the strategies for preventing dry eye.

Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function Open

Wenjie Zhu, Guan‐Yu Chen, Zhiqiang Xiao, Minzhen Wang, Zhuang Li , et al. · 2025

Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained u…

Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial Open

Jing Li, Yinglin Liao, Shiyao Zhang, Ling Jin, Nathan Congdon , et al. · 2024

Objective To assess efficacy and safety of laughter exercise in patients with symptomatic dry eye disease. Design Non-inferiority randomised controlled trial. Setting Recruitment was from clinics and community and the trial took place at Z…

Urban Particulate Matter Triggers Meibomian Gland Dysfunction Open

Melody Pi Yin Tu, Ren Liu, Jianwen Xue, Bing Xiao, Jing Li , et al. · 2024

These results provided direct evidence for the toxicity of UPM in MG. UPM-induced activation of pyroptosis and mitogen-activated protein kinase/nuclear factor-κB signaling pathway might account for the inflammatory MGD.

Alteration of Meibum Lipidomics Profiling in Patients With Chronic Ocular Graft-Versus-Host Disease Open

Wenxin Zhao, Jing Yang, Yinglin Liao, Boyu Yang, Shujiao Lin , et al. · 2023

Altered meibum in coGVHD is characterized by a decrease of glycerolipids and an increase of glycerophospholipids and may be significantly reversed by topical anti-inflammatory therapy.

Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function Open

Bing Xiao, Dianlei Guo, Ren Liu, Melody Pi Yin Tu, Ziyan Chen , et al. · 2023

Physical obstruction of tear drainage in STDOB or GTDOB mice leads to LG dysfunction, suggesting a long-distance interaction between the tear drainage conduits and the LG. We propose that various components of the lacrimal apparatus should…

3% diquafosol sodium eye drops in Chinese patients with dry eye: a phase IV study Open

Wenying Wang, Xiaonan Sun, Jiangyue Zhao, Ji‐Long Hao, Shaozhen Zhao , et al. · 2023

Introduction The efficacy and safety of 3% diquafosol sodium eye drops in Chinese patients with dry eye in the real-world setting remains unclear. Methods 3099 patients with dry eye symptoms were screened according to Asia Dry Eye Society …

Meibomian Gland Dysfunction as a Manifestation of IFAP Syndrome Open

Yuanjun Shang, Lingyi Liang · 2023

Posterior segment complications and the risk factors after allogeneic hematopoietic stem cell transplantation Open

Boyu Yang, Shaowen Wu, Shanshan Yu, Xiaoling Liang, Qifa Liu , et al. · 2022

Ocular surface disease index questionnaire as a sensitive test for primary screening of chronic ocular graft-versus-host disease Open

Jing Yang, Wenxin Zhao, Yinglin Liao, Shaowen Wu, Jing Li , et al. · 2022

The OSDI questionnaire can be used as a simple screening test for coGVHD as demonstrated by its high sensitivity and specificity in the transplant clinic and patients' self-monitoring. An OSDI greater than 19.4 could be considered an ophth…

Impaired sleep quality in children with allergic conjunctivitis and their parents Open

Jing Li, Shiyao Zhang, Zixin Fan, Ren Liu, Ling Jin , et al. · 2022

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway Open

Ren Liu, Jing Li, Yue Xu, Ziyan Chen, Huijing Ye , et al. · 2022

MLT attenuated lipogenesis, apoptosis, and autophagy in HMGECs induced by proinflammatory stimuli, indicating the protective potential of MLT in MGD.

Metagenomic Analysis Reveals the Heterogeneity of Conjunctival Microbiota Dysbiosis in Dry Eye Disease Open

Qiaoxing Liang, Jing Li, Yanli Zou, Xiao Hu, Xiuli Deng , et al. · 2021

Background: Dry eye disease (DED) is a multifactorial inflammatory disease of the ocular surface. It is hypothesized that dysbiosis of the conjunctival microbiota contributes to the development of DED. However, species-level compositions o…

Association of Allergic Conjunctivitis With Health-Related Quality of Life in Children and Their Parents Open

Shiyao Zhang, Jing Li, Ren Liu, Hubert Yuenhei Lao, Zixin Fan , et al. · 2021

These findings suggest AC has a negative association with health-related QOL for children and their parents, especially in children with VKC/AKC or higher corneal fluorescein staining scores.

Quantitative evaluation of lipid layer thickness and blinking in children with allergic conjunctivitis Open

Boyu Yang, Kuiyao Wen, Jing Li, Shiyao Zhang, Zixin Fan , et al. · 2021

Age differences in ocular demodicosis: Demodex profiles and clinical manifestations Open

Jing Li, Xiaohui Luo, Yinglin Liao, Lingyi Liang · 2021

Young patients with ocular demodicosis tend to have more D. brevis infestation, more MGL, and more corneal involvement.

Update on the application of amniotic membrane in immune-related ocular surface diseases Open

Lingyi Liang, Ziyan Chen, Hubert Yuenhei Lao · 2021

Immune-related ocular surface diseases, a group of diseases in which immune dysregulation damages the ocular surface, can induce uncontrolled inflammation and persistent epithelial defect, thus leading to the most severe forms of acute ker…

The Landscape of Host-Microbiota Interactions at the Ocular Mucosa Open

Qiaoxing Liang, Bin Zou, Xifang Li, Xiuli Deng, Jing Li , et al. · 2021

Defining Dry Eye from a Clinical Perspective Open

Kazuo Tsubota, Stephen C. Pflugfelder, Zuguo Liu, Christophe Baudouin, Hyo Myung Kim , et al. · 2020

Over the past decades, the number of patients with dry eye disease (DED) has increased dramatically. The incidence of DED is higher in Asia than in Europe and North America, suggesting the involvement of cultural or racial factors in DED e…

Characterization of conjunctival microbiome dysbiosis associated with allergic conjunctivitis Open

Qiaoxing Liang, Jing Li, Shiyao Zhang, Yinglin Liao, Shixin Guo , et al. · 2020

Background: Evidence shows that the microbiome plays an important role in allergic diseases. The associations between the conjunctival microbiome dysbiosis and ocular allergy remain unknown. This study investigates the characteristics of t…

Corneal transplantation in the aftermath of the COVID-19 pandemic: an international perspective Open

Marcus Ang, Aline Silveira Moriyama, Kathryn Colby, Gerard Sutton, Lingyi Liang , et al. · 2020

Corneal blindness is the third leading cause of blindness worldwide.1 Corneal transplantation remains the only method of restoring vision in eyes with end-stage corneal decompensation and is the most frequently performed type of transplant…

Aerobic Exercise Increases Tear Secretion and Decreases Inflammatory Cytokines in Healthy Subjects Open

Hao Li, Fei Li, Rouxi Zhou, Kai Gao, Lingyi Liang , et al. · 2020

AE could promote tear secretion and decrease inflammatory cytokines in healthy subjects.

Geographic Difference Shaped Human Ocular Surface Metagenome of Young Han Chinese From Beijing, Wenzhou, and Guangzhou Cities Open

Yuhua Deng, Xiaofeng Wen, Xiao Hu, Yanli Zou, Chan Zhao , et al. · 2020

Our study provides a reference catalog of the healthy conjunctival metagenome and raises a concern for environmental influences on the ocular surface microbiome.

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society Open

Kazuo Tsubota, Norihiko Yokoi, Hitoshi Watanabe, Murat Doğru, Takashi Kojima , et al. · 2019

The 2017 consensus report of the Asia Dry Eye Society (ADES) on the definition and diagnosis of dry eyes described dry eye disease as “Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms an…

Nine-year analysis of isolated pathogens and antibiotic susceptibilities of microbial keratitis from a large referral eye center in southern China Open

Lin Li, Fang Duan, Yunlan Yang, Lou B, Lingyi Liang , et al. · 2019

Lixia Lin,* Fang Duan,* Yao Yang, Bingsheng Lou, Lingyi Liang, Xiaofeng LinZhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally …

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