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Overlapping functions between <i>Lamp2a</i> and <i>Lamp2b</i> in cardiac autophagy Open
LAMP2 is a ubiquitously expressed protein critical for autophagy. Alternative splicing gives rise to three isoforms. However, the roles of major LAMP2 isoforms in the heart are not known. To address this knowledge gap, we generated lamp2a …
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired Open
Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degra…
The Small GTPase Rab7 Regulates Release of Mitochondria in Extracellular Vesicles in Response to Lysosomal Dysfunction Open
Mitochondrial quality control is critical for cardiac homeostasis as these organelles are responsible for generating most of the energy needed to sustain contraction. Dysfunctional mitochondria are normally degraded via intracellular degra…
View article: Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy
Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy Open
Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in Tafazzin ( TAZ ), encoding a mitochondrial acyltransferase required for cardiolipin remodeling…
View article: ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis
ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis Open
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully elucidated. Several lines of e…
View article: Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39
Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39 Open
Objective— Leukocyte flux contributes to thrombus formation in deep veins under pathological conditions, but mechanisms that inhibit venous thrombosis are incompletely understood. Ectonucleotide di(tri)phosphohydrolase 1 ( ENTPD1 or Cd39 )…
Inhibition of late Na<sup>+</sup> current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats Open
Late Na + current ( I NaL ) is enhanced in myocytes of animals with chronic heart failure and patients with hypertrophic cardiomyopathy. To define the role of I NaL in diastolic heart failure, the effects of GS-458967 (GS-967), a potent I …