Lihan Zhang
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View article: Identification of biomarkers of Shenhailong formula in benign prostatic hyperplasia treatment: An observation study using network pharmacology and Mendelian randomization analysis
Identification of biomarkers of Shenhailong formula in benign prostatic hyperplasia treatment: An observation study using network pharmacology and Mendelian randomization analysis Open
Shenhailong formula, a classic herbal prescription, shows potential in treating benign prostatic hyperplasia (BPH), but its candidate components and mechanisms remain unclear. This study aimed to preliminarily clarify its therapeutic mecha…
View article: Jiannao Pills alleviate depression-like behavior in chronic unpredictable mild stress-induced mice through NF-κB/NLRP3 pathway
Jiannao Pills alleviate depression-like behavior in chronic unpredictable mild stress-induced mice through NF-κB/NLRP3 pathway Open
Objective Depression is a significant mental disorder that damages human health. Jiannao Pills (JNW) as a commercial mediation has demonstrated its effectiveness in depression treatment but the mechanism remains elusive. This research ende…
View article: Neuroinflammation and hypoxia promote astrocyte phenotypic transformation and propel neurovascular dysfunction in brain arteriovenous malformation
Neuroinflammation and hypoxia promote astrocyte phenotypic transformation and propel neurovascular dysfunction in brain arteriovenous malformation Open
Brain arteriovenous malformation (BAVM) is a complex cerebrovascular disease characterized by an abnormal high-flow vascular network, which increases the risk of hemorrhage, particularly in young individuals. Endothelial dysfunction has tr…
View article: Identification and Validation of Prognostic Genes Related to Histone Lactylation Modification in Glioblastoma: An Integrated Analysis of Transcriptome and Single-cell RNA Sequencing
Identification and Validation of Prognostic Genes Related to Histone Lactylation Modification in Glioblastoma: An Integrated Analysis of Transcriptome and Single-cell RNA Sequencing Open
Background: The impact of histone lactylation modification (HLM) on glioblastoma (GBM) progression is not well understood. This study aimed to identify HLM-associated prognostic genes in GBM and explore their mechanisms of action. <…
View article: Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy
Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy Open
View article: NGR1 reduces neuronal apoptosis through regulation of ITGA11 following subarachnoid hemorrhage
NGR1 reduces neuronal apoptosis through regulation of ITGA11 following subarachnoid hemorrhage Open
Subarachnoid hemorrhage (SAH), a prevalent cerebrovascular condition associated with a high mortality rate, frequently results in neuronal apoptosis and an unfavorable prognosis. The adjunctive use of traditional Chinese medicine (TCM) wit…
View article: A metabologenomics strategy for rapid discovery of polyketides derived from modular polyketide synthases
A metabologenomics strategy for rapid discovery of polyketides derived from modular polyketide synthases Open
A metabologenomics workflow using mass defect filtering (MDF) and bioinformatics-based structural prediction was established for rapid screening of modular polyketide natural products, and led to the identification of 22 polyketides.
View article: Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage
Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage Open
Under subarachnoid hemorrhage (SAH) conditions, astrocytes undergo a marked intensification of glycolytic activity, resulting in the generation of substantial amounts of lactate to maintain the energy demand for neurons and other brain cel…
View article: Licochalcone A mitigates aflatoxin B1-induced immunotoxicity via ferroptosis in bursa of broilers and macrophages
Licochalcone A mitigates aflatoxin B1-induced immunotoxicity via ferroptosis in bursa of broilers and macrophages Open
View article: Bioinformatic prediction of the stereoselectivity of modular polyketide synthase: an update of the sequence motifs in ketoreductase domain
Bioinformatic prediction of the stereoselectivity of modular polyketide synthase: an update of the sequence motifs in ketoreductase domain Open
Polyketides are a major class of natural products, including bioactive medicines such as erythromycin and rapamycin. They are often rich in stereocenters biosynthesized by the ketoreductase (KR) domain within the polyketide synthase (PKS) …
View article: BRCA1 as a target for attenuating paclitaxel resistance by Halofuginone treatment in basal-like breast cancer
BRCA1 as a target for attenuating paclitaxel resistance by Halofuginone treatment in basal-like breast cancer Open
Breast cancer presents significant challenges in oncology, particularly basal-like breast cancer (BLBC), which shows resistance to paclitaxel treatment. This study examines the efficacy of halofuginone (HF), a compound from traditional Chi…
View article: Dynamics of transformed nonlinear waves for the (2+1)-dimensional pKP-BKP equation: interactions and molecular waves
Dynamics of transformed nonlinear waves for the (2+1)-dimensional pKP-BKP equation: interactions and molecular waves Open
In this paper, the dynamical behaviors of transformed nonlinear waves for the (2+1)-dimensional combined potential Kadomtsev-Petviashvili and B-type Kadomtsev-Petviashvili (pKP-BKP) equation are investigated, which can be used to reveal th…
View article: The causality between Type 2 diabetes and breast cancer: a bidirectional two-sample Mendelian randomization study
The causality between Type 2 diabetes and breast cancer: a bidirectional two-sample Mendelian randomization study Open
Objective: Observational studies showed that Type 2 diabetes increased the risk of breast cancer, and vice versa. However, it is uncertain whether the link is causal or just due to confounding factors. Using bidirectional Men…
View article: Expanding Catalytic Versatility of Modular Polyketide Synthases for Alcohol Biosynthesis
Expanding Catalytic Versatility of Modular Polyketide Synthases for Alcohol Biosynthesis Open
Modular polyketide synthases biosynthesize structurally diverse natural products by a set of catalytic domains that operate in an assembly line fashion. Although extensive research has focused on the rational reprogramming of modular polyk…
View article: Diversity and distribution of biosynthetic gene clusters in agricultural soil microbiomes
Diversity and distribution of biosynthetic gene clusters in agricultural soil microbiomes Open
Bacterial secondary metabolites serve as an important source of molecules for drug discovery. They also play an important function in mediating the interactions of microbial producers with their living environment and surrounding organisms…
View article: Plug-and-Play Engineering of Modular Polyketide Synthases
Plug-and-Play Engineering of Modular Polyketide Synthases Open
Modular polyketide synthases (PKSs) are multidomain, assembly line enzymes that biosynthesize complex antibiotics such as erythromycin and rapamycin. The modular characteristic of PKSs has made them an ideal platform for custom production …
View article: Molecular mechanisms of Rhizoma Dioscoreae in breast cancer treatment: a network pharmacology and experimental verification
Molecular mechanisms of Rhizoma Dioscoreae in breast cancer treatment: a network pharmacology and experimental verification Open
Background Breast cancer poses a significant threat on human health. Rhizoma Dioscoreae (RD), a traditional Chinese medicinal herb, has shown positive effect in breast cancer treatment; however, the underlying molecular mechanisms remain u…
View article: Jiannao pills mitigate chronic restraint stress-induced anxiety in mice through the regulation of intestinal microflora
Jiannao pills mitigate chronic restraint stress-induced anxiety in mice through the regulation of intestinal microflora Open
Jiannao pills effectively ameliorated chronic restraint anxiety-like behaviors in mice and enhanced their neural functions potentially through the regulation of their intestinal microflora.
View article: Extracellular vesicles of the Gram-positive gut symbiont Bifidobacterium longum induce immune-modulatory, anti-inflammatory effects
Extracellular vesicles of the Gram-positive gut symbiont Bifidobacterium longum induce immune-modulatory, anti-inflammatory effects Open
The gut microbiota is now well known to affect the host’s immune system. One way of bacterial communication with host cells is via the secretion of vesicles, small membrane structures containing various cargo. Research on vesicles secreted…
View article: SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease
SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease Open
Neuroinflammation plays a crucial role in the pathogenesis and progression of Alzheimer's disease (AD). The Sterile Alpha and Toll Interleukin Receptor Motif-containing protein 1 (SARM1) has been shown to promote axonal degeneration and is…
View article: An unexpected hydratase synthesizes the green light-absorbing pigment fucoxanthin
An unexpected hydratase synthesizes the green light-absorbing pigment fucoxanthin Open
The ketocarotenoid fucoxanthin and its derivatives can absorb blue–green light enriched in marine environments. Fucoxanthin is widely adopted by phytoplankton species as a main light-harvesting pigment, in contrast to land plants that prim…
View article: Multi-Omics Reveals Molecular Linkages Associated with Neurodegeneration after Acute Ischemic Stroke
Multi-Omics Reveals Molecular Linkages Associated with Neurodegeneration after Acute Ischemic Stroke Open
View article: Development of an Active Peptide Inhibitor to Block TIM-3/Gal-9 Interaction for Cancer Immunotherapy
Development of an Active Peptide Inhibitor to Block TIM-3/Gal-9 Interaction for Cancer Immunotherapy Open
View article: A Case of Digital Pseudoaneurysm Following Sharp Injury to a Digit.
A Case of Digital Pseudoaneurysm Following Sharp Injury to a Digit. Open
Background. A 74-year-old woman presented to the plastic surgery hand trauma clinic with painful, pulsatile swelling in her left index finger following a sharp incision injury to the digit. A diagnosis of digital artery pseudoaneury…
View article: A Very Unusual Burn Complication: Bilateral Endogenous Bacterial Endophthalmitis.
A Very Unusual Burn Complication: Bilateral Endogenous Bacterial Endophthalmitis. Open
This report describes a rare, sight-threatening complication that arose from an infected burn wound in an otherwise healthy patient. It highlights the importance of prompt diagnosis and treatment to preserve vision and the need for burn su…
View article: Peptide vaccine from cancer-testis antigen ODF2 can potentiate the cytotoxic T lymphocyte infiltration through IL-15 in non-MSI-H colorectal cancer
Peptide vaccine from cancer-testis antigen ODF2 can potentiate the cytotoxic T lymphocyte infiltration through IL-15 in non-MSI-H colorectal cancer Open
View article: Green diatom mutants reveal an intricate biosynthetic pathway of fucoxanthin
Green diatom mutants reveal an intricate biosynthetic pathway of fucoxanthin Open
Fucoxanthin is a major light-harvesting pigment in ecologically important algae such as diatoms, haptophytes, and brown algae (Phaeophyceae). Therefore, it is a major driver of global primary productivity. Species of these algal groups are…
View article: A <i>Streptomyces</i> P450 enzyme dimerizes isoflavones from plants
A <i>Streptomyces</i> P450 enzyme dimerizes isoflavones from plants Open
Dimerization is a widespread natural strategy that enables rapid structural diversification of natural products. However, our understanding of the dimerization enzymes involved in this biotransformation is still limited compared to the num…
View article: Generalized fourth-order decompositions of imaginary time path integral: Implications of the harmonic oscillator
Generalized fourth-order decompositions of imaginary time path integral: Implications of the harmonic oscillator Open
The imaginary time path integral formalism offers a powerful numerical tool for simulating thermodynamic properties of realistic systems. We show that, when second-order and fourth-order decompositions are employed, they share a remarkable…
View article: Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage
Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage Open
Background Microglial necroptosis exacerbates neurodegenerative diseases, central nervous system injury and demonstrates a pro-inflammatory process, but its contribution to subarachnoid hemorrhage (SAH) is poorly characterized. BCL-2 homol…