Lihong Yin
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View article: Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validation
Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validation Open
Perfluorooctane sulfonate (PFOS), a widely used persistent organic pollutant, has been implicated in multiple toxicities. However, its nephrotoxic mechanisms remain unclear. Chronic kidney disease (CKD) is a growing global health concern. …
View article: Effects of delayed mating on the fecundity, fertility, and longevity of Assara inouei Yamanaka
Effects of delayed mating on the fecundity, fertility, and longevity of Assara inouei Yamanaka Open
Assara inouei Yamanaka is an important pest of pomegranate fruits in Southwest China. The effects of different ages (0, 1, 3, 5, and 7 days after emergence) and sexes (females, males, or both sexes) of adults delayed mating on their fecund…
View article: TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway Open
Introduction Intracerebral hemorrhage (ICH) often triggers oxidative stress through reactive oxygen species (ROS). Transforming growth factor-β-activated kinase 1 (TAK1) plays a pivotal role in regulating oxidative stress and inflammation …
View article: HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity
HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity Open
Defective erythropoiesis is one of the causes of anemia and leukemia. However, the mechanisms underlying defective erythropoiesis under a low-dose environment of benzene are poorly understood. In the present study, multiple omics (transcri…
View article: Legends for Video and Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Legends for Video and Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Legends for Video and Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Legends for Video and Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Legends for Video and Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Legends for Video and Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Data from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Data from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Targeted therapies for cancer are inherently limited by the inevitable recurrence of resistant disease after initial responses. To define early molecular changes within residual tumor cells that persist after treatment, we analyzed drug-se…
View article: Supplementary Video from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Supplementary Video from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Supplementary Video from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Supplementary Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Supplementary Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Supplementary Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Supplementary Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Supplementary Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Supplementary Figures 1-3 from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Data from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Data from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Targeted therapies for cancer are inherently limited by the inevitable recurrence of resistant disease after initial responses. To define early molecular changes within residual tumor cells that persist after treatment, we analyzed drug-se…
View article: Supplementary Methods from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Supplementary Methods from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Supplementary Methods from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Supplementary Video from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Supplementary Video from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Supplementary Video from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Supplementary Methods from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
Supplementary Methods from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents Open
Supplementary Methods from MET-Independent Lung Cancer Cells Evading EGFR Kinase Inhibitors Are Therapeutically Susceptible to BH3 Mimetic Agents
View article: Structural and optical properties of iron ions doped near-infrared persistent spinel-type phosphors
Structural and optical properties of iron ions doped near-infrared persistent spinel-type phosphors Open
View article: Case Report: Isolated facial and trigeminal nerve palsy without ataxia in anti-GQ1b antibody syndrome secondary to Mycoplasma pneumonia
Case Report: Isolated facial and trigeminal nerve palsy without ataxia in anti-GQ1b antibody syndrome secondary to Mycoplasma pneumonia Open
The presence of anti-GQ1b antibodies in serum or cerebrospinal fluid is a diagnostic indicator of the Miller–Fisher variant of Guillain–Barré syndrome (GBS), whereas anti-GQ1b antibody syndrome is rarely presented as acute bilateral pain i…
View article: A pattern shift in SARS-CoV-2 Omicron variant transmission after the city lockdown--observational study based upon daily reported addresses of infected cases (Preprint)
A pattern shift in SARS-CoV-2 Omicron variant transmission after the city lockdown--observational study based upon daily reported addresses of infected cases (Preprint) Open
BACKGROUND Varied degrees of lockdown have been imposed for dozens of jurisdictions upon facing the SARS-CoV-2 epidemics during the past two years. Areal lockdown has been demonstrated effective to reduce the morbility and mortality of CO…
View article: A pattern shift in SARS-CoV-2 Omicron variant transmission after the city lockdown--observational study based upon daily reported addresses of infected cases
A pattern shift in SARS-CoV-2 Omicron variant transmission after the city lockdown--observational study based upon daily reported addresses of infected cases Open
Background Varied degrees of lockdown have been imposed for dozens of jurisdictions upon facing the SARS-CoV-2 epidemics during the past two years. Areal lockdown has been demonstrated effective to reduce the morbility and mortality of COV…
View article: Network meta-analysis of curative efficacy of different acupuncture methods on obesity combined with insulin resistance
Network meta-analysis of curative efficacy of different acupuncture methods on obesity combined with insulin resistance Open
Objective This study aims to systematically evaluate the curative efficacy of different acupuncture methods in the treatment of obesity combined with insulin resistance in randomized clinical trials (RCTs) by network meta-analysis. Methods…
View article: Network meta-analysis of curative efficacy of different acupuncture methods on obesity combined with insulin resistance
Network meta-analysis of curative efficacy of different acupuncture methods on obesity combined with insulin resistance Open
Review question / Objective: Population：Patients diagnosed as obesity with insulin resistance. Obesity reference: Consensus of experts on the Prevention and treatment of adult obesity in China in 2011 and Consensus of Chinese experts on me…
View article: Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure
Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure Open
View article: Mediating role of psychological capital between occupational stress and depressive symptoms in disease prevention and control personnel
Mediating role of psychological capital between occupational stress and depressive symptoms in disease prevention and control personnel Open
BackgroundOccupational stress and depressive symptoms of disease prevention and control personnel are serious.ObjectiveTo investigate the relationship between occupational stress, psychological capital, and depressive symptoms of disease p…
View article: The Inhibitory Effect of Powdery Mildew-Induced Volatiles from Rose on Host Selection Behavior of Beet Armyworm Moths (Lepidoptera: Noctuidae)
The Inhibitory Effect of Powdery Mildew-Induced Volatiles from Rose on Host Selection Behavior of Beet Armyworm Moths (Lepidoptera: Noctuidae) Open
Plant-mediated indirect interactions (PMIIs) between phytopathogenic fungi and herbivorous insects on shared host plants occur in nature. Knowledge of PMIIs is critical in plant molecular breeding and integrated pest management. We studied…
View article: Li-Rich Antiperovskite/Nitrile Butadiene Rubber Composite Electrolyte for Sheet-Type Solid-State Lithium Metal Battery
Li-Rich Antiperovskite/Nitrile Butadiene Rubber Composite Electrolyte for Sheet-Type Solid-State Lithium Metal Battery Open
Lithium-rich antiperovskites (LiRAPs) hold great promise to be the choice of solid-state electrolytes (SSEs) owing to their high ionic conductivity, low activation energy, and low cost. However, processing sheet-type solid-state Li metal b…
View article: Noise-induced Hearing Loss and Hypertension Among Occupational Noise-exposed Workers: a Pilot Study Based on Baseline Data
Noise-induced Hearing Loss and Hypertension Among Occupational Noise-exposed Workers: a Pilot Study Based on Baseline Data Open
Background: Noise is a widespread occupational hazardous factor affecting the health of workers in occupational health field. Noise-induced hearing loss (NIHL) and hypertension are the important biological adverse effects caused by occupat…
View article: Research Progress and Prospect of Blockchain + Agricultural Science Data Management
Research Progress and Prospect of Blockchain + Agricultural Science Data Management Open
Agricultural data management plays an important role in the development of agriculture and even the national economy. Data has been written into the national documents as a factor of production, and its importance is not strict. As the tec…
View article: H3K4me3 and H3K27ac Activated lncRPL34-AS1 Acts as a Suppressor of Esophageal Squamous Cell Carcinoma via Targeting miR-575/ACAA2 Axis and Binding to ALOX12B and CAT
H3K4me3 and H3K27ac Activated lncRPL34-AS1 Acts as a Suppressor of Esophageal Squamous Cell Carcinoma via Targeting miR-575/ACAA2 Axis and Binding to ALOX12B and CAT Open
Background: Long noncoding RNAs (lncRNAs) are abnormally expressed in a broad type of cancers and play significant roles that regulate tumor development and metastasis. However, the pathological roles of lncRNAs in esophageal squamous cell…
View article: Identification of Cancer Stem Cell Molecular Markers and Effects of hsa-miR-21-3p on Stemness in Esophageal Squamous Cell Carcinoma
Identification of Cancer Stem Cell Molecular Markers and Effects of hsa-miR-21-3p on Stemness in Esophageal Squamous Cell Carcinoma Open
Cancer stem cells (CSCs) are closely related to tumor resistance and tumor recurrence in esophageal squamous cell carcinoma (ESCC). The lack of specific biomarkers to identify and isolate CSCs has led to the slow progression of research on…
View article: Trends in hepatocellular carcinoma research from 2008 to 2017: a bibliometric analysis
Trends in hepatocellular carcinoma research from 2008 to 2017: a bibliometric analysis Open
Objectives To comprehensively analyse the global scientific outputs of hepatocellular carcinoma (HCC) research. Methods Data of publications were downloaded from the Web of Science Core Collection. We used CiteSpace IV and Excel 2016 to an…
View article: Identification of extracellular matrix protein 1 as a potential plasma biomarker of ESCC by proteomic analysis using iTRAQ and 2D‐LC‐MS/MS
Identification of extracellular matrix protein 1 as a potential plasma biomarker of ESCC by proteomic analysis using iTRAQ and 2D‐LC‐MS/MS Open
Purpose This study was aimed to conduct a proteomics profiling analysis on plasma obtained from ESCC patients with the goal of identifying appropriate plasma protein biomarkers in the progression of ESCC. Experimental design Plasma from 28…