Li‐Hua Du
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View article: Selective oxidation of high-concentration 5-hydroxymethylfurfural to 2,5-furan dicarboxylic acid at room temperature in water by synergic electronic effect of bimetallic RuCo/NC catalyst
Selective oxidation of high-concentration 5-hydroxymethylfurfural to 2,5-furan dicarboxylic acid at room temperature in water by synergic electronic effect of bimetallic RuCo/NC catalyst Open
View article: Two-Step Tandem Synthesis of Coumarin Derivatives Containing Bioamide Skeleton Catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in Sustainable Continuous-Flow Microreactors
Two-Step Tandem Synthesis of Coumarin Derivatives Containing Bioamide Skeleton Catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in Sustainable Continuous-Flow Microreactors Open
Due to their remarkable biological and pharmacological activities such as antibacterial, antifungal, anticoagulant, antioxidant, anticancer, and anti-inflammatory properties, synthesis of coumarins and their derivatives has attracted consi…
View article: Continuous flow biocatalysis: synthesis of purine nucleoside esters catalyzed by lipase TL IM from <i>Thermomyces lanuginosus</i>
Continuous flow biocatalysis: synthesis of purine nucleoside esters catalyzed by lipase TL IM from <i>Thermomyces lanuginosus</i> Open
Purine nucleoside ester is one of the derivatives of purine nucleoside, which has antiviral and anticancer activities.
View article: Pyrazine derivative synthesis in a continuous-flow system: a green synthesis of pyrazinamide from pyrazine esters and amines catalyzed by Lipozyme® TL IM from <i>Thermomyces lanuginosus</i>
Pyrazine derivative synthesis in a continuous-flow system: a green synthesis of pyrazinamide from pyrazine esters and amines catalyzed by Lipozyme® TL IM from <i>Thermomyces lanuginosus</i> Open
The continuous flow synthesis of a series of pyrazinamide derivatives catalyzed by Lipozyme® TL IM was successfully achieved with good scalability. A continuous production of pyrazinamide derivatives was first performed coupled with enzyme…
View article: Development of a green, concise synthesis of nicotinamide derivatives catalysed by Novozym® 435 from <i>Candida antarctica</i> in sustainable continuous-flow microreactors
Development of a green, concise synthesis of nicotinamide derivatives catalysed by Novozym® 435 from <i>Candida antarctica</i> in sustainable continuous-flow microreactors Open
A continuous production of nicotinamide derivatives was performed for the first time by exploiting the continuous-flow microreactors coupled with enzymes.
View article: Two-step tandem synthesis of sugar-containing pyrimidine derivatives catalyzed by Lipozyme® TL IM in continuous-flow microreactors
Two-step tandem synthesis of sugar-containing pyrimidine derivatives catalyzed by Lipozyme® TL IM in continuous-flow microreactors Open
In continuous-flow microreactors, a two-step tandem scheme was developed to synthesize a series of sugar-containing pyrimidine derivatives with excellent regioselectivity, which can effectively avoid the separation and purification of inte…
View article: New native Bacillus thuringiensis strains induce high insecticidal action against Culex pipiens pallens larvae and adults
New native Bacillus thuringiensis strains induce high insecticidal action against Culex pipiens pallens larvae and adults Open
View article: Bioengineering of a Lactococcus lactis subsp. lactis strain enhances nisin production and bioactivity
Bioengineering of a Lactococcus lactis subsp. lactis strain enhances nisin production and bioactivity Open
Lactococcus lactis subsp. lactis is a food bacterium that has been utilized for decades in food fermentation and the development of high-value industrial goods. Among these, nisin, which is produced by several strains of L . lactis subsp. …
View article: Bioengineering of a<i>Lactococcus lactis</i>subsp.<i>lactis</i>strain enhances nisin production and bioactivity
Bioengineering of a<i>Lactococcus lactis</i>subsp.<i>lactis</i>strain enhances nisin production and bioactivity Open
Lactococcus lactis subsp. lactis is a food bacterium that has been utilized for decades in food fermentation and the development of high-value industrial goods. Among these, nisin is produced by several strains of L. lactis subsp. lactis p…
View article: New native Bacillus thuringiensis strains induce high insecticidal action against mosquito larvae and adults
New native Bacillus thuringiensis strains induce high insecticidal action against mosquito larvae and adults Open
Mosquitoes of many species are key vectors in disease transmission, causing millions of fatalities worldwide each year. Insecticidal formulations based on Bacillus thuringiensis have been considered one of the most effective, ecologically …
View article: Remarkly Enhanced Upconversion Luminescence in Hybrid of Ag Film/Colloidal Crystal/Nayf4:Er/Yb Nanorods
Remarkly Enhanced Upconversion Luminescence in Hybrid of Ag Film/Colloidal Crystal/Nayf4:Er/Yb Nanorods Open
View article: Construction of Bi-Enzyme Self-Assembly Clusters Based on SpyCatcher/SpyTag for the Efficient Biosynthesis of (R)-Ethyl 2-hydroxy-4-phenylbutyrate
Construction of Bi-Enzyme Self-Assembly Clusters Based on SpyCatcher/SpyTag for the Efficient Biosynthesis of (R)-Ethyl 2-hydroxy-4-phenylbutyrate Open
Cascade reactions catalyzed by multi-enzyme systems are important in science and industry and can be used to synthesize drugs and nutrients. In this study, two types of macromolecules of bi-enzyme self-assembly clusters (BESCs) consisting …
View article: Microfluidics Biocatalysis System Applied for the Synthesis of N-Substituted Benzimidazole Derivatives by Aza-Michael Addition
Microfluidics Biocatalysis System Applied for the Synthesis of N-Substituted Benzimidazole Derivatives by Aza-Michael Addition Open
Benzimidazole scaffolds became an attractive subject due to their broad spectrum of pharmacological activities. In this work, a methodology was developed for the synthesis of N-substituted benzimidazole derivatives from benzimidazoles and …
View article: Highly Efficient Synthesis of Cinnamamides from Methyl Cinnamates and Phenylethylamines Catalyzed by Lipozyme® TL IM under Continuous-Flow Microreactors
Highly Efficient Synthesis of Cinnamamides from Methyl Cinnamates and Phenylethylamines Catalyzed by Lipozyme® TL IM under Continuous-Flow Microreactors Open
While a few derivatives of cinnamamides exhibited anti-inflammatory and/ or analgesic activity, in this study, we developed a highly efficient method for the synthesis of cinnamamides from methyl cinnamates and phenylethylamines catalyzed …
View article: Endophytic bacterium Bacillus aryabhattai induces novel transcriptomic changes to stimulate plant growth
Endophytic bacterium Bacillus aryabhattai induces novel transcriptomic changes to stimulate plant growth Open
In nature, plants interact with a wide range of microorganisms, and most of these microorganisms could induce growth through the activation of important molecular pathways. The current study evaluated whether the endophytic bacterium Bacil…
View article: Continuous Flow Biocatalysis: Synthesis of Coumarin Carboxamide Derivatives by Lipase TL IM from Thermomyces lanuginosus
Continuous Flow Biocatalysis: Synthesis of Coumarin Carboxamide Derivatives by Lipase TL IM from Thermomyces lanuginosus Open
Coumarin carboxamide derivatives are important building blocks for organic synthesis and chemical biology due to their excellent biopharmaceutical properties. In this paper, we demonstrate for the first time a two-step enzymatic synthesis …
View article: Plant Growth-Promoting Endophytic Bacillus Aryabhattai Triggers Novel Genes to Induce Plant Growth
Plant Growth-Promoting Endophytic Bacillus Aryabhattai Triggers Novel Genes to Induce Plant Growth Open
Background: In nature, plants interact with a wide range of microorganisms. Most of these microorganisms have the ability to promote plant growth through the induction of important molecular pathways. The current work evaluated whether the…
View article: Endophytic Bacillus altitudinis Strain Uses Different Novelty Molecular Pathways to Enhance Plant Growth
Endophytic Bacillus altitudinis Strain Uses Different Novelty Molecular Pathways to Enhance Plant Growth Open
The identification and use of endophytic bacteria capable of triggering plant growth is an important aim in sustainable agriculture. In nature, plants live in alliance with multiple plant growth-promoting endophytic microorganisms. In the …
View article: Heat-killed endophytic bacterium induces robust plant defense responses against important pathogens
Heat-killed endophytic bacterium induces robust plant defense responses against important pathogens Open
Stress caused by pathogens strongly damages plants. Developing products to control plant disease is an important challenge in sustainable agriculture. In this study, a heat-killed endophytic bacterium (HKEB), Bacillus aryabhattai , is used…
View article: Ring-Opening of Epoxides with Amines for Synthesis of β-Amino Alcohols in a Continuous-Flow Biocatalysis System
Ring-Opening of Epoxides with Amines for Synthesis of β-Amino Alcohols in a Continuous-Flow Biocatalysis System Open
An efficient method for the preparation of β-amino alcohols catalyzed by lipase TL IM from Thermomyces lanuginosus in a continuous-flow reactor was developed. The eco-friendly biocatalyst combined with continuous-flow reaction technology d…
View article: Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines
Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines Open
A continuous-flow procedure for the synthesis of β-amino acid esters has been developed via lipase-catalyzed Michael reaction of various aromatic amines with acrylates. Lipase TL IM from Thermomyces lanuginosus was first used to catalyze M…
View article: A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from<i>Thermomyces lanuginosus</i>in continuous-flow microreactors
A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from<i>Thermomyces lanuginosus</i>in continuous-flow microreactors Open
An effective and environmentally friendly two-step tandem protocol for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM in continuous-flow microreactors has been developed.
View article: Enzymatic Synthesis of Thioesters from Thiols and Vinyl Esters in a Continuous-Flow Microreactor
Enzymatic Synthesis of Thioesters from Thiols and Vinyl Esters in a Continuous-Flow Microreactor Open
The preparation of thioesters through the lipase-catalysed transesterification reaction of thiols with vinyl carboxyl esters is described. The reactions were carried out by Lipase TL IM from Thermomyces lanuginosus as a catalyst and perfor…
View article: Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor Open
We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity.