Lihuan Guan
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View article: The SG90 cohort of the oldest-old in Singapore
The SG90 cohort of the oldest-old in Singapore Open
View article: Dietary ingredients inducing cellular senescence in animals and humans: A systematic review
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review Open
View article: The Association of Physical Function and Physical Performance With DNA Methylation Clocks in Oldest-Old Living in Singapore—The SG90 Cohort
The Association of Physical Function and Physical Performance With DNA Methylation Clocks in Oldest-Old Living in Singapore—The SG90 Cohort Open
Deoxyribonucleic acid (DNA) methylation (DNAm) clocks estimate biological age according to DNA methylation. This study investigated the associations between measures of physical function and physical performance and 10 DNAm clocks in the o…
View article: Sarcopenia Is Poorly Documented in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT)
Sarcopenia Is Poorly Documented in Geriatric Rehabilitation Inpatients: Restoring Health of Acutely Unwell Adults (RESORT) Open
Introduction: Sarcopenia is highly prevalent in older inpatients. However, it is unclear if sarcopenia is documented routinely in geriatric rehabilitation. This study aimed to investigate the documentation of sarcopenia in medical records …
View article: Targeting aging with urolithin A in humans: A systematic review
Targeting aging with urolithin A in humans: A systematic review Open
View article: Higher blood biochemistry-based biological age developed by advanced deep learning techniques is associated with frailty in geriatric rehabilitation inpatients: RESORT
Higher blood biochemistry-based biological age developed by advanced deep learning techniques is associated with frailty in geriatric rehabilitation inpatients: RESORT Open
Higher biological age was associated with severe frailty in geriatric rehabilitation inpatients with less comorbidity burden.
View article: The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT
The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT Open
View article: Therapeutic effect of dietary ingredients on cellular senescence in animals and humans: A systematic review
Therapeutic effect of dietary ingredients on cellular senescence in animals and humans: A systematic review Open
Resveratrol, vitamin E and soy protein isolate are promising senotherapeutics studied in animal models. Studies testing dietary ingredients with senotherapeutic potential in humans are limited and translation is highly warranted.
View article: Higher Blood Biochemistry-Based Biological Age Developed by Advanced Deep Learning Techniques is Associated with Frailty in Geriatric Rehabilitation Inpatients: Resort
Higher Blood Biochemistry-Based Biological Age Developed by Advanced Deep Learning Techniques is Associated with Frailty in Geriatric Rehabilitation Inpatients: Resort Open
View article: The therapeutic effect of diet and dietary ingredients on cellular senescence in animals and humans: A systematic review
The therapeutic effect of diet and dietary ingredients on cellular senescence in animals and humans: A systematic review Open
Background Cellular senescence is a permanent state of cell cycle arrest and has been regarded as a therapeutic target for ageing and age-related diseases. Several senotherapeutic agents have been proposed, including compounds derived from…
View article: Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence
Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence Open
View article: Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients: RESORT
Association of a modified laboratory frailty index with adverse outcomes in geriatric rehabilitation inpatients: RESORT Open
View article: Comparison of the modified Frailty-Index based on laboratory tests and the Clinical Frailty Scale in predicting mortality among geriatric rehabilitation inpatients: RESORT
Comparison of the modified Frailty-Index based on laboratory tests and the Clinical Frailty Scale in predicting mortality among geriatric rehabilitation inpatients: RESORT Open
View article: Unresolved inflammation during hospitalization is associated with post-discharge institutionalization and mortality in geriatric rehabilitation inpatients: The RESORT cohort
Unresolved inflammation during hospitalization is associated with post-discharge institutionalization and mortality in geriatric rehabilitation inpatients: The RESORT cohort Open
Inflammation characterized by lower albumin during acute hospitalization and, higher CRP and lower albumin during geriatric rehabilitation was associated with mortality in geriatric rehabilitation inpatients. Increased CRP during geriatric…
View article: Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice
Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice Open
View article: SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation
SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation Open
View article: Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence
Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence Open
View article: A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis
A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis Open
Rationale: MicroRNAs are known to influence the development of a variety of cancers. Previous studies revealed that miR-1291 has antiproliferative functions in cancer cells. Carnitine palmitoyltransferase 1C (CPT1C) has a vital role…
View article: CORRIGENDUM FOR “Lipid Profiling of Peri-implantation Endometrium in Patients With Premature Progesterone Rise in the Late Follicular Phase”
CORRIGENDUM FOR “Lipid Profiling of Peri-implantation Endometrium in Patients With Premature Progesterone Rise in the Late Follicular Phase” Open
View article: Correction to: Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages
Correction to: Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages Open
View article: Lipid Profiling of Peri-implantation Endometrium in Patients With Premature Progesterone Rise in the Late Follicular Phase
Lipid Profiling of Peri-implantation Endometrium in Patients With Premature Progesterone Rise in the Late Follicular Phase Open
Context Late follicular phase elevation in serum progesterone (P) during controlled ovarian hyperstimulation negatively affects the outcome of assisted reproductive technology by contributing to endometrial-embryo asynchrony. There are sti…
View article: Metabolomics and Lipidomics Reveal the Effect of Hepatic Vps33b Deficiency on Bile Acids and Lipids Metabolism
Metabolomics and Lipidomics Reveal the Effect of Hepatic Vps33b Deficiency on Bile Acids and Lipids Metabolism Open
Vascular protein sorting-associated protein 33B (VPS33B) plays important roles in hepatic polarity, which directly maintains the functional structure of the liver. It has reported that VPS33B has close association with arthrogryposis, rena…
View article: p53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression
p53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression Open
View article: Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages
Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages Open
View article: Discovery of Phosphatidic Acid, Phosphatidylcholine, and Phosphatidylserine as Biomarkers for Early Diagnosis of Endometriosis
Discovery of Phosphatidic Acid, Phosphatidylcholine, and Phosphatidylserine as Biomarkers for Early Diagnosis of Endometriosis Open
The sensitivity and specificity of clinical diagnostic indicators and non-invasive diagnostic methods for endometriosis at early stage is not optimal. Previous studies demonstrated that abnormal lipid metabolism was involved in the patholo…
View article: Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming
Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming Open
View article: p53‐mediated regulation of bile acid disposition attenuates cholic acid‐induced cholestasis in mice
p53‐mediated regulation of bile acid disposition attenuates cholic acid‐induced cholestasis in mice Open
Background and Purpose The tumour suppressor p53 is traditionally recognized as a surveillance molecule to preserve genome integrity. Recent studies have demonstrated that it contributes to metabolic diseases. Here, we investigated the rol…
View article: PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C
PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C Open
Carnitine palmitoyltransferase 1C (CPT1C), an enzyme located in the outer mitochondria membrane, has a crucial role in fatty acid transport and oxidation. It is also involved in cell proliferation and is a potential driver for cancer cell …