Lihui Yuwen
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View article: Ultrasound-responsive multifunctional nanodroplets for enhanced biofilm penetration and synergistic sonodynamic/gas therapy of bacterial implant infections
Ultrasound-responsive multifunctional nanodroplets for enhanced biofilm penetration and synergistic sonodynamic/gas therapy of bacterial implant infections Open
View article: Antibacterial nanoagents: an emerging arsenal against bacterial persisters
Antibacterial nanoagents: an emerging arsenal against bacterial persisters Open
Bacterial persisters represent a metabolically dormant or slow-growing subpopulation within bacterial communities that exhibit resistance to antibiotics. These cells are capable of resuming active proliferation upon the removal of environm…
View article: Ultrasound/magnetic field dual-responsive Fe3O4/glucose oxidase catalytic microbubbles for enhanced bacterial biofilm elimination
Ultrasound/magnetic field dual-responsive Fe3O4/glucose oxidase catalytic microbubbles for enhanced bacterial biofilm elimination Open
View article: Magnetic Field/Ultrasound-Responsive Fe3O4 Microbubbles for Targeted Mechanical/Catalytic Removal of Bacterial Biofilms
Magnetic Field/Ultrasound-Responsive Fe3O4 Microbubbles for Targeted Mechanical/Catalytic Removal of Bacterial Biofilms Open
Conventional antibiotics are limited by drug resistance, poor penetration, and inadequate targeting in the treatment of bacterial biofilm-associated infections. Microbubble-based ultrasound (US)-responsive drug delivery systems can disrupt…
View article: Near‐Infrared Light‐Responsive Cu<sub>2</sub>MoS<sub>4</sub>@GelMA Hydrogel with Photothermal Therapy, Antibacterial Effect and Bone Immunomodulation for Accelerating Infection Elimination and Fracture Healing
Near‐Infrared Light‐Responsive Cu<sub>2</sub>MoS<sub>4</sub>@GelMA Hydrogel with Photothermal Therapy, Antibacterial Effect and Bone Immunomodulation for Accelerating Infection Elimination and Fracture Healing Open
Managing fracture infections is a significant challenge in trauma orthopedics, given the limited self‐healing capacity of fractures and the difficulty in eradicating infections. In this study, Cu 2 MoS 4 nanoparticles (CMSs) with are prepa…
View article: Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection
Recent Advances in DNA Nanotechnology-Enabled Biosensors for Virus Detection Open
Virus-related infectious diseases are serious threats to humans, which makes virus detection of great importance. Traditional virus-detection methods usually suffer from low sensitivity and specificity, are time-consuming, have a high cost…
View article: On-Demand Free Radical Release by Laser Irradiation for Photothermal-Thermodynamic Biofilm Inactivation and Tooth Whitening
On-Demand Free Radical Release by Laser Irradiation for Photothermal-Thermodynamic Biofilm Inactivation and Tooth Whitening Open
Dental diseases associated with biofilm infections and tooth staining affect billions of people worldwide. In this study, we combine photothermal agents (MoS2@BSA nanosheets, MB NSs), a thermolysis free-radical initiator (AIPH), and carbom…
View article: Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell‐Mediated Tumor Immunotherapy (Adv. Healthcare Mater. 17/2023)
Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell‐Mediated Tumor Immunotherapy (Adv. Healthcare Mater. 17/2023) Open
Aerobic Vaginitis In article number 202203028, Yongbin Mou, Zhaogang Teng, Heng Dong, and co-workers report a Ti3C2 MXene-based nanoplatform (MXP) with high-efficiency near-infrared photothermal conversion and immunocompetent loading capac…
View article: Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell‐Mediated Tumor Immunotherapy
Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell‐Mediated Tumor Immunotherapy Open
Traditional dendritic cell (DC)‐mediated immunotherapy is usually suppressed by weak immunogenicity in tumors and generally leads to unsatisfactory outcomes. Synergistic exogenous/endogenous immunogenic activation can provide an alternativ…
View article: Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection
Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection Open
The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating the body's immune system to elimin…
View article: Ultrasound-responsive catalytic microbubbles enhance biofilm elimination and immune activation to treat chronic lung infections
Ultrasound-responsive catalytic microbubbles enhance biofilm elimination and immune activation to treat chronic lung infections Open
Efficient treatment of chronic lung infections caused by Pseudomonas aeruginosa biofilms is a great challenge because of drug tolerance and immune evasion issues. Here, we develop ultrasound-responsive catalytic microbubbles with biofilm e…
View article: Efficient Preparation of Small-Sized Transition Metal Dichalcogenide Nanosheets by Polymer-Assisted Ball Milling
Efficient Preparation of Small-Sized Transition Metal Dichalcogenide Nanosheets by Polymer-Assisted Ball Milling Open
Two-dimensional (2D) transition metal dichalcogenide nanosheets (TMDC NSs) have attracted growing interest due to their unique structure and properties. Although various methods have been developed to prepare TMDC NSs, there is still a gre…
View article: Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell-mediated Tumor Immunotherapy
Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell-mediated Tumor Immunotherapy Open
Traditional dendritic cell (DC)-mediated immunotherapy is usually suppressed by weak immunogenicity in tumors and generally leads to unsatisfactory outcomes. Synergistic exogenous/endogenous immunogenic activation can provide an alternativ…
View article: Biofilm microenvironment response nanoplatform synergistically degrades biofilm structure and relieves hypoxia for efficient sonodynamic therapy
Biofilm microenvironment response nanoplatform synergistically degrades biofilm structure and relieves hypoxia for efficient sonodynamic therapy Open
Treatment of bacterial biofilms remains a great challenge in the clinic. Recently, ultrasound (US)-driven antimicrobial sonodynamic therapy (aSDT) has been considered as an emerging therapeutic strategy for the treatment of biofilm infecti…
View article: Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy (Small 32/2022)
Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy (Small 32/2022) Open
Elastic Nanovaccines In article number 2201108, Zhaogang Teng, Heng Dong, Yongbin Mou, and co-workers report a soft mesoporous organosilica-based nanovaccine (SMONV) and demonstrate that elastic SMONV evokes robust antitumor immune cascade…
View article: Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections
Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections Open
View article: Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy
Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy Open
Nanovaccine‐based immunotherapy (NBI) has the ability to initiate dendritic cell (DC)‐mediated tumor‐specific immune responses and maintain long‐term antitumor immune memory. To date, the mechanism by which the mechanical properties of nan…
View article: Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections
Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections Open
Traditional antibiotic treatment has limited efficacy for the drug-tolerant bacteria present in biofilms because of their unique metabolic conditions in the biofilm infection microenvironment. Modulating the biofilm infection microenvironm…
View article: Recent development of nanomedicine for the treatment of bacterial biofilm infections
Recent development of nanomedicine for the treatment of bacterial biofilm infections Open
Bacterial biofilm related infections are ever growing issues for global medical community. Traditional antibiotic therapy is usually ineffective for treating them because the bacteria inside biofilms have evolved with multiple mechanisms t…
View article: Continuous preparation of antimony nanocrystals with near infrared photothermal property by pulsed laser ablation in liquids
Continuous preparation of antimony nanocrystals with near infrared photothermal property by pulsed laser ablation in liquids Open
Antimony nanocrystals (Sb NCs) are of interest in energy storage, catalysis and cancer therapy for its special physical, chemical and biomedical properties. However, methodology challenges still remain in preparation of colloidal Sb NCs, d…
View article: Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections
Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections Open
The formation of bacterial biofilms closely associates with infectious diseases. Until now, precise diagnosis and effective treatment of bacterial biofilm infections are still in great need. Herein, a novel multifunctional theranostic nano…
View article: Antibody-Functionalized MoS2 Nanosheets for Targeted Photothermal Therapy of Staphylococcus aureus Focal Infection
Antibody-Functionalized MoS2 Nanosheets for Targeted Photothermal Therapy of Staphylococcus aureus Focal Infection Open
Bacterial biofilm-related diseases cause serious hazard to public health and bring great challenge to the traditional antibiotic treatment. Photothermal therapy (PTT) has been recognized as a promising alternative solution. However, the th…
View article: A postsynthetic ion exchange method for tunable doping of hydroxyapatite nanocrystals
A postsynthetic ion exchange method for tunable doping of hydroxyapatite nanocrystals Open
Hydroxyapatite nanocrystals were doped with various metal ions with tunable doping level and preserved morphology via a postsynthetic approach.
View article: Mesoporous Nanoparticles: Facile Synthesis of Yolk-Shell-Structured Triple-Hybridized Periodic Mesoporous Organosilica Nanoparticles for Biomedicine (Small 26/2016)
Mesoporous Nanoparticles: Facile Synthesis of Yolk-Shell-Structured Triple-Hybridized Periodic Mesoporous Organosilica Nanoparticles for Biomedicine (Small 26/2016) Open
On page 3550, G. Lu, L. Wang, and co-workers report yolk–shell structured periodic mesoporous organosilica (PMO) nanoparticles simultaneously incorporated with ethane, thioether, and benzene moieties. The unique yolk–shell structure is for…