Liisa Keltikangas‐Järvinen
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View article: Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids Open
View article: Polygenic Risk for Schizophrenia and Personality Traits in Individuals Without Non-Affective Psychosis
Polygenic Risk for Schizophrenia and Personality Traits in Individuals Without Non-Affective Psychosis Open
View article: Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets
Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets Open
In recent years, there has been a notably increased interest in the study of multivariate interactions and emergent higher-order dependencies. This is particularly evident in the context of identifying synergistic sets, which are defined a…
View article: Multilayer Network of Cardiovascular Diseases and Depression via Multipartite Projection
Multilayer Network of Cardiovascular Diseases and Depression via Multipartite Projection Open
Cardiovascular diseases (CVD) and depression exhibit significant comorbidity, which is highly predictive of poor clinical outcomes. Yet, the underlying biological pathways remain challenging to decipher, presumably due to the non-linear as…
View article: Gene expression networks regulated by human personality
Gene expression networks regulated by human personality Open
View article: Polygenic risk for depression predicting temperament trajectories over 15 years – A general population study
Polygenic risk for depression predicting temperament trajectories over 15 years – A general population study Open
High polygenic risk for major depression may predict differences in temperament trajectories among those who have not developed any severe affective disorders.
View article: Polygenic risk for schizophrenia predicting social trajectories in a general population sample
Polygenic risk for schizophrenia predicting social trajectories in a general population sample Open
Background We investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRS SCZ -specific or evide…
View article: Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study
Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study Open
Schizophrenia is often regarded as a disorder of premature aging. We investigated (a) whether polygenic risk for schizophrenia (PRS sch ) relates to pace of epigenetic aging and (b) whether personal dispositions toward active and emotional…
View article: Polygenic liabilities underlying job stress and exhaustion over a 10-year follow-up: A general population study
Polygenic liabilities underlying job stress and exhaustion over a 10-year follow-up: A general population study Open
We investigated whether individuals, who have a high polygenic loading for schizophrenia and major depression (PGL) but have not developed the respective disorders, are still susceptible to experience milder forms of ill-being in terms of …
View article: Childhood family environment predicting psychotic disorders over a 37-year follow-up – A general population cohort study
Childhood family environment predicting psychotic disorders over a 37-year follow-up – A general population cohort study Open
Our results suggest that childhood family environment and atmosphere patterns as such contribute to the risk for developing adulthood mental disorders with relative disorder specificity. The results emphasize the importance of both individ…
View article: Under the thin skin of narcissus: Facial muscle activity reveals amplified emotional responses to negative social evaluation in individuals with grandiose narcissistic traits
Under the thin skin of narcissus: Facial muscle activity reveals amplified emotional responses to negative social evaluation in individuals with grandiose narcissistic traits Open
Individuals with grandiose narcissism exhibit enhanced antagonism and a defensive pattern of discordance between their emotional and physiological reactions to self‐threatening evaluations. Although theoretical perspectives link narcissist…
View article: The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study
The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study Open
Introduction Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to hel…
View article: Stress-Related Exhaustion, Polygenic Cognitive Potential, and Cognitive Test Performance – A General Population Study
Stress-Related Exhaustion, Polygenic Cognitive Potential, and Cognitive Test Performance – A General Population Study Open
View article: Ethnicity, minority status, and inter-group bias: A systematic meta-analysis on fMRI studies
Ethnicity, minority status, and inter-group bias: A systematic meta-analysis on fMRI studies Open
Introduction This meta-analysis investigated (1) whether ethnic minority and majority members have a neural inter-group bias toward each other, and (2) whether various ethnic groups (i.e., White, Black, and Asian) are processed in the brai…
View article: Does social intolerance vary according to cognitive styles, genetic cognitive capacity, or education?
Does social intolerance vary according to cognitive styles, genetic cognitive capacity, or education? Open
Background Low education, low cognitive abilities, and certain cognitive styles are suggested to predispose to social intolerance and prejudices. Evidence is, however, restricted by comparatively small samples, neglect of confounding varia…
View article: A genome-wide association study of total child psychiatric problems scores
A genome-wide association study of total child psychiatric problems scores Open
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performe…
View article: Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses—a general population study
Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses—a general population study Open
View article: Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms
Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms Open
Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the …
View article: The relationship between temperament, polygenic score for intelligence and cognition: A population‐based study of middle‐aged adults
The relationship between temperament, polygenic score for intelligence and cognition: A population‐based study of middle‐aged adults Open
We investigated whether temperament modifies an association between polygenic intelligence potential and cognitive test performance in midlife. The participants ( n = 1647, born between 1962 and 1977) were derived from the Young Finns Stud…
View article: Neural basis of in-group bias and prejudices: A systematic meta-analysis
Neural basis of in-group bias and prejudices: A systematic meta-analysis Open
In-group favoritism and prejudices relate to discriminatory behaviors but, despite decades of research, understanding of their neural correlates has been limited. A systematic coordinate-based meta-analysis of functional magnetic resonance…
View article: Rewards of Compassion: Dispositional Compassion Predicts Lower Job Strain and Effort-Reward Imbalance Over a 11-Year Follow-Up
Rewards of Compassion: Dispositional Compassion Predicts Lower Job Strain and Effort-Reward Imbalance Over a 11-Year Follow-Up Open
Dispositional compassion has been shown to predict higher well-being and to be associated with lower perceived stress and higher social support. Thus, compassion may be a potential individual factor protecting from job strain. The current …
View article: Genetic differential susceptibility to the parent–child relationship quality and the life span development of compassion
Genetic differential susceptibility to the parent–child relationship quality and the life span development of compassion Open
The development of compassion for others might be influenced by the social experiences made during childhood and has a genetic component. No research has yet investigated whether the parent–child relationship quality interacts with genetic…
View article: Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course
Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course Open
We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands ( N = 13,471) and Australia ( N = 5628), pol…
View article: Genetic association study of childhood aggression across raters, instruments, and age.
Genetic association study of childhood aggression across raters, instruments, and age. Open
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assesso…
View article: Genetic association study of childhood aggression across raters, instruments, and age
Genetic association study of childhood aggression across raters, instruments, and age Open
View article: Evolution of genetic networks for human creativity
Evolution of genetic networks for human creativity Open
View article: Compassion protects against vital exhaustion and negative emotionality
Compassion protects against vital exhaustion and negative emotionality Open
View article: Functional Polymorphisms in Oxytocin and Dopamine Pathway Genes and the Development of Dispositional Compassion Over Time: The Young Finns Study
Functional Polymorphisms in Oxytocin and Dopamine Pathway Genes and the Development of Dispositional Compassion Over Time: The Young Finns Study Open
Background: We define compassion as an enduring disposition that centers upon empathetic concern for another person's suffering and the motivation to act to alleviate it. The contribution of specific candidate genes to the development of d…
View article: The relationship of socioeconomic status in childhood and adulthood with compassion: A study with a prospective 32-year follow-up
The relationship of socioeconomic status in childhood and adulthood with compassion: A study with a prospective 32-year follow-up Open
The objective of this study was to investigate (i) whether childhood family SES predicts offspring’s compassion between ages 20–50 years and (ii) whether adulthood SES predicts compassion or vice versa. We used the prospective population-b…
View article: C-reactive protein and temperament: An instrumental variable analysis
C-reactive protein and temperament: An instrumental variable analysis Open