Lijia Cheng
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View article: On Ameliorating Liver Function through Bee Sting Therapy – Take Nonalcoholic Fatty Liver Disease Rats as an Example
On Ameliorating Liver Function through Bee Sting Therapy – Take Nonalcoholic Fatty Liver Disease Rats as an Example Open
Purpose: Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in its early stage and liver fibrosis with time. Bee venom is beneficial against obesity, while there are limited reports on bee sting therapy (BST), …
View article: Immunology in Osseointegration After Implantation
Immunology in Osseointegration After Implantation Open
Bone tissue is renowned for its regenerative capabilities, yet handling extensive defects and complex fractures presents considerable medical challenges. Osteoimmunology, studying the complex mechanism of the mutual influence within the ra…
View article: Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications
Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications Open
Additive manufacturing, commonly known as 3D printing technology, has become a prominent topic of research globally in recent years and is playing an increasingly important role in various industries. Particularly within the healthcare sec…
View article: Evaluation of osteogenic properties of a novel injectable bone-repair material containing strontium in vitro and in vivo
Evaluation of osteogenic properties of a novel injectable bone-repair material containing strontium in vitro and in vivo Open
Objective: This study aims to develop and evaluate the biocompatibility and osteogenic potential of a novel injectable strontium-doped hydroxyapatite bone-repair material. Methods: The properties of strontium-doped hydroxyapatite/chitosan …
View article: Effect of 3D-Printed Porous Titanium Alloy Pore Structure on Bone Regeneration: A Review
Effect of 3D-Printed Porous Titanium Alloy Pore Structure on Bone Regeneration: A Review Open
As a biomedical material, porous titanium alloy has gained widespread recognition and application within the field of orthopedics. Its remarkable biocompatibility, bioactivity, and mechanical properties establish it as a promising material…
View article: Comparison of different hydroxyapatite composites for bone tissue repair: <i>In vitro</i> and <i>in vivo</i> analyses.
Comparison of different hydroxyapatite composites for bone tissue repair: <i>In vitro</i> and <i>in vivo</i> analyses. Open
The ability of SA/nHA composite microspheres in osteogenesis and angiogenesis is clearly superior to that of the CS/nHA group and is comparable to that of CaP/nHA, which has superior osteogenesis ability, indicating that SA/nHA composite m…
View article: A Comprehensive Review of Surface Modification Techniques for Enhancing the Biocompatibility of 3D-Printed Titanium Implants
A Comprehensive Review of Surface Modification Techniques for Enhancing the Biocompatibility of 3D-Printed Titanium Implants Open
The advent of three-dimensional (3D) printing technology has revolutionized the production of customized titanium (Ti) alloy implants. The success rate of implantation and the long-term functionality of these implants depend not only on de…
View article: [Research progress on biocomposites based on bioactive glass].
[Research progress on biocomposites based on bioactive glass]. Open
Bioactive glass (BG) has been widely used in the preparation of artificial bone scaffolds due to its excellent biological properties and non-cytotoxicity, which can promote bone and soft tissue regeneration. However, due to the brittleness…
View article: Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds
Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds Open
Bone defects and dysfunctions are prevalent among patients, resulting from various causes such as trauma, tumors, congenital malformations, inflammation, and infection. The demand for bone defect repair materials is second only to blood tr…
View article: Surface modification improving the biological activity and osteogenic ability of 3D printing porous dental implants
Surface modification improving the biological activity and osteogenic ability of 3D printing porous dental implants Open
Objective: To explore the mechanical properties, biological activity, and osteogenic ability of 3D printed TC4 titanium (Ti) alloy dental implants treated with surface modification. Methods: Dental implants with 30% porosity were manufactu…
View article: A review of current effective COVID-19 testing methods and quality control
A review of current effective COVID-19 testing methods and quality control Open
View article: Impact of nanotechnology on conventional and artificial intelligence-based biosensing strategies for the detection of viruses
Impact of nanotechnology on conventional and artificial intelligence-based biosensing strategies for the detection of viruses Open
View article: Effect of Surface Modification of PEEK Artificial Phalanx by 3D Printing on its Biological Activity
Effect of Surface Modification of PEEK Artificial Phalanx by 3D Printing on its Biological Activity Open
Objective: Polyetheretherketone (PEEK) is widely used as an orthopedic implant material owing to its good biocompatibility and mechanical strength; however, PEEK implants are biologically inert, resulting in suboptimal cellular responses a…
View article: 3D Bioprinting tissue analogs: Current development and translational implications
3D Bioprinting tissue analogs: Current development and translational implications Open
Three-dimensional (3D) bioprinting is a promising and rapidly evolving technology in the field of additive manufacturing. It enables the fabrication of living cellular constructs with complex architectures that are suitable for various bio…
View article: Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis
Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis Open
For the past 50 years, hydroxyapatite (HA) has been widely used in bone defect repair because it is the main inorganic component of the mineral phase of a human bone. Extensive preclinical and clinical studies have shown that strontium (Sr…
View article: Preparation and Characterization of 3D Printed Porous 45S5 Bioglass Bioceramic for Bone Tissue Engineering Application
Preparation and Characterization of 3D Printed Porous 45S5 Bioglass Bioceramic for Bone Tissue Engineering Application Open
Three-dimensional (3D) printing technology provides advanced technical support for designing personalized bone tissue engineering scaffold. In this study, two porous diffusing models, namely, average and layered perforated cylindrical scaf…
View article: Identification of Small-Molecule Inhibitors for Osteosarcoma Targeted Therapy: Synchronizing In Silico, In Vitro, and In Vivo Analyses
Identification of Small-Molecule Inhibitors for Osteosarcoma Targeted Therapy: Synchronizing In Silico, In Vitro, and In Vivo Analyses Open
Objective: The study aimed to explore a new approach for the treatment of osteosarcoma through combining biomaterials with next-generation small molecule–based targeted therapy. Methods: The model of osteosarcoma was established by 4-hydro…
View article: Bone Tissue Engineering through 3D Bioprinting of Bioceramic Scaffolds: A Review and Update
Bone Tissue Engineering through 3D Bioprinting of Bioceramic Scaffolds: A Review and Update Open
Trauma and bone loss from infections, tumors, and congenital diseases make bone repair and regeneration the greatest challenges in orthopedic, craniofacial, and plastic surgeries. The shortage of donors, intrinsic limitations, and complica…
View article: The Relationship between Osteoinduction and Vascularization: Comparing the Ectopic Bone Formation of Five Different Calcium Phosphate Biomaterials
The Relationship between Osteoinduction and Vascularization: Comparing the Ectopic Bone Formation of Five Different Calcium Phosphate Biomaterials Open
Objective: The objective of this study is to compare the bone induction of five kinds of calcium phosphate (Ca-P) biomaterials implanted in mice and explore the vascularization and particle-size-related osteoinductive mechanism. Methods: T…
View article: 3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives
3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives Open
Lijia Cheng, 1 Shoma Suresh K, 2 Hongyan He, 1 Ritu Singh Rajput, 2 Qiyang Feng, 1 Saravanan Ramesh, 2 Yuzhuang Wang, 1 Sasirekha Krishnan, 2 Serge Ostrovidov, 3 Gulden Camci-Unal, 4 Murugan Ramalingam 2 1School of Basic Medicine, Chengdu …
View article: The preparation and application of calcium phosphate biomedical composites in filling of weight-bearing bone defects
The preparation and application of calcium phosphate biomedical composites in filling of weight-bearing bone defects Open
View article: Exercise Promotes the Osteoinduction of HA/β-TCP Biomaterials via the Wnt Signaling Pathway
Exercise Promotes the Osteoinduction of HA/β-TCP Biomaterials via the Wnt Signaling Pathway Open
To investigate the osteoinductive mechanism triggered by hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) biomaterials in mice which keep exercising. Methods: The HA/β-TCP biomaterials were implanted in the muscle of bilateral thighs (non-…
View article: Identification of Novel Key Targets and Candidate Drugs in Oral Squamous Cell Carcinoma
Identification of Novel Key Targets and Candidate Drugs in Oral Squamous Cell Carcinoma Open
Background: Oral Squamous Cell Carcinoma (OSCC) is the most common malignant epithelial neoplasm. It is located within the top 10 ranking incidence of cancers with a poor prognosis and low survival rates. New breakthroughs of therapeutic s…
View article: [Study of vascularization of hydroxyapatite/tricalcium phosphate biomaterials implanted in mice during osteoinduction].
[Study of vascularization of hydroxyapatite/tricalcium phosphate biomaterials implanted in mice during osteoinduction]. Open
This study aims to explore the vascularization of hydroxyapatite/tricalcium phosphate(HA/TCP)biomaterials implanted in mice during osteoinduction. The HA/TCP biomaterials were implanted in muscle of mice, and2, 4, 6, 8, 10 and 12 weeks aft…