Li Hu
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View article: A corticospinal signature for interindividual pain sensitivity
A corticospinal signature for interindividual pain sensitivity Open
Pain sensitivity variations represent a critical frontier in pain neuroscience, where advanced neuroimaging has mapped cerebral correlates of nociception for decades, yet conventional brain-centric models persistently overlook the spinal c…
View article: Altered regional brain activity underlying the higher postoperative analgesic requirements in abstinent smokers: A prospective cohort study
Altered regional brain activity underlying the higher postoperative analgesic requirements in abstinent smokers: A prospective cohort study Open
Perioperative abstinent smokers experience heightened pain sensitivity and increased postoperative analgesic requirements, likely due to nicotine withdrawal-induced hyperalgesia. However, the underlying neural mechanisms in humans remain u…
View article: Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials
Perceived sensorimotor synchrony enhances pain modulation and attenuates laser-evoked potentials Open
Sensorimotor synchronization to music, referring to the temporal alignment of movement with auditory rhythms, has been associated with immersive engagement and enhanced pleasure. In the present study, we investigated its analgesic effects …
View article: CoSpine open access simultaneous cortico-spinal fMRI database of thermal pain and motor tasks
CoSpine open access simultaneous cortico-spinal fMRI database of thermal pain and motor tasks Open
View article: Neural variability reliably encodes interindividual differences in the perception of pain intensity
Neural variability reliably encodes interindividual differences in the perception of pain intensity Open
Neural activity varies dramatically across time. While such neural variability has been associated with cognition, its relationship with pain remains largely unexplored. Here, we systematically investigated the relationship between neural …
View article: Towards Reliable Statistical Guarantees for LLM Alignment Evaluation
Towards Reliable Statistical Guarantees for LLM Alignment Evaluation Open
View article: A Narrative Study on the Reconstruction of Life Meaning in Breast Cancer Patients
A Narrative Study on the Reconstruction of Life Meaning in Breast Cancer Patients Open
This study, conducted during an internship at the Tumor Hospital of S Province, employs a qualitative research paradigm. The primary research subjects were 11 hospitalized breast cancer patients, with data collected through semi-structured…
View article: Research on the Competence Dilemma and Countermeasures of Rural Youth Social Workers——Taking City Z in Guangdong Province as an Example
Research on the Competence Dilemma and Countermeasures of Rural Youth Social Workers——Taking City Z in Guangdong Province as an Example Open
With the advancement of the rural revitalization strategy, the importance of rural social work has become increasingly prominent. As the main force in this field, the competence of rural young social workers directly affects the quality of…
View article: Tracing and Mitigating Hallucinations in Multimodal LLMs via Dynamic Attention Localization
Tracing and Mitigating Hallucinations in Multimodal LLMs via Dynamic Attention Localization Open
Multimodal Large Language Models (MLLMs) achieve strong performance on tasks like image captioning and visual question answering, but remain prone to hallucinations, where generated text conflicts with the visual input. Prior work links th…
View article: A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals
A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals Open
Revealing the neural underpinnings of pain sensitivity is crucial for understanding how the brain encodes individual differences in pain and advancing personalized pain treatments. Here, six large and diverse functional magnetic resonance …
View article: A comprehensive EEG dataset of laser-evoked potentials for pain research
A comprehensive EEG dataset of laser-evoked potentials for pain research Open
Understanding the neural mechanisms of pain is key to the development of novel pain diagnostic and treatment strategies. Here, we present a large-scale, comprehensive electroencephalogram (EEG) dataset of laser-evoked potentials (LEPs) fro…
View article: Electroencephalographic neural correlates and deep learning analysis of a single brief focused mindfulness meditation in young adults: A pilot study
Electroencephalographic neural correlates and deep learning analysis of a single brief focused mindfulness meditation in young adults: A pilot study Open
Objective This study builds on brief focused mindfulness meditation (BFMM) to examine its associations with physiological indices and electroencephalographic (EEG) neural features related to stress in young adults. In addition, deep learni…
View article: Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice
Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice Open
Spontaneous rescue behavior enhances the well-being and survival of social animals, yet the neural mechanisms underlying the recognition and response to conspecifics in need remain unclear. Here, we report that observer mice experience dis…
View article: Tuning-Free Accountable Intervention for LLM Deployment – a Metacognitive Approach
Tuning-Free Accountable Intervention for LLM Deployment – a Metacognitive Approach Open
Large Language Models (LLMs) have brought significant advances across various NLP tasks through few-shot or zero-shot prompting, bypassing the need for parameter tuning. However, the "black-box" nature behind their massive parameter sizes …
View article: Neural variability reliably and selectively encodes pain discriminability
Neural variability reliably and selectively encodes pain discriminability Open
Neural activity varies dramatically across time. While such variability has been associated with cognition, its relationship with pain remains largely unexplored. Here, we systematically investigated the relationship between neural variabi…
View article: Mechanistic Unveiling of Transformer Circuits: Self-Influence as a Key to Model Reasoning
Mechanistic Unveiling of Transformer Circuits: Self-Influence as a Key to Model Reasoning Open
Transformer-based language models have achieved significant success; however, their internal mechanisms remain largely opaque due to the complexity of non-linear interactions and high-dimensional operations. While previous studies have dem…
View article: Evaluating Data Influence in Meta Learning
Evaluating Data Influence in Meta Learning Open
As one of the most fundamental models, meta learning aims to effectively address few-shot learning challenges. However, it still faces significant issues related to the training data, such as training inefficiencies due to numerous low-con…
View article: The benefits and safety of a virtual reality intervention in patients suffering from acute and chronic pain: A pilot study
The benefits and safety of a virtual reality intervention in patients suffering from acute and chronic pain: A pilot study Open
Background To overcome the challenge of psychotherapist scarcity in applying pain psychotherapy in clinical practice, we developed a virtual reality (VR) program delivering weeks of pain psychotherapy without psychotherapists, with a focus…
View article: Neural network dynamics underlying the bottom-up perception and top-down regulation processes of empathy
Neural network dynamics underlying the bottom-up perception and top-down regulation processes of empathy Open
Contemporary theoretical models of empathy propose that it involves both bottom-up perception and top-down regulation processes. Although previous studies have explored brain regions involved in empathy, direct evidence for a hierarchical …
View article: Mechanistic Unveiling of Transformer Circuits: Self-Influence as a Key to Model Reasoning
Mechanistic Unveiling of Transformer Circuits: Self-Influence as a Key to Model Reasoning Open
View article: The effect of brief and focused mindfulness meditation on young adults using EEG approach with machine learning
The effect of brief and focused mindfulness meditation on young adults using EEG approach with machine learning Open
Our study seeks to investigate the neural mechanisms underlying brief mindfulness meditation through the utilization of electroencephalogram (EEG) recordings and machine learning techniques. Twenty-four participants underwent mindfulness t…
View article: Burden and Temporal Trends of Valvular Heart Disease‐Related Heart Failure From 1990 to 2019 and Projection Up to 2030 in Group of 20 Countries: An Analysis for the Global Burden of Disease Study 2019
Burden and Temporal Trends of Valvular Heart Disease‐Related Heart Failure From 1990 to 2019 and Projection Up to 2030 in Group of 20 Countries: An Analysis for the Global Burden of Disease Study 2019 Open
Background The aim of this study was to characterize the burden of valvular heart disease (VHD)‐related heart failure (HF) in Group of 20 (G20) countries. Methods and Results Using data from the 2019 Global Burden of Disease Study, we esti…
View article: Advances and challenges in neuroimaging-based pain biomarkers
Advances and challenges in neuroimaging-based pain biomarkers Open
Identifying neural biomarkers of pain has long been a central theme in pain neuroscience. Here, we review the state-of-the-art candidates for neural biomarkers of acute and chronic pain. We classify these potential neural biomarkers into f…
View article: Decreasing the pressure of endotracheal tube cuff slowly with a constant speed can decrease coughing incidence during extubation: a randomized clinical trial
Decreasing the pressure of endotracheal tube cuff slowly with a constant speed can decrease coughing incidence during extubation: a randomized clinical trial Open
Decreasing the pressure of endotracheal tube cuff slowly with a constant speed can significantly reduce the incidence of coughing during extubating period, stabilize hemodynamics, and reduce the incidence of adverse reactions.
View article: ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain
ENIGMA-Chronic Pain: a worldwide initiative to identify brain correlates of chronic pain Open
Altres ajuts: The ENIGMA-Chronic Pain working group gratefully acknowledges support from the United States National Institutes of Health (NIH) Big Data to Knowledge (BD2K) award (U54EB020403 to P.M.T.). This work was supported by a Rebecca…
View article: Subthalamic and pallidal oscillations and their couplings reflect dystonia severity and improvements by deep brain stimulation
Subthalamic and pallidal oscillations and their couplings reflect dystonia severity and improvements by deep brain stimulation Open
Beyond pallidal theta power, subthalamic beta power, STN-GPi couplings in theta and beta bands, play a crucial role in understanding the pathophysiological mechanism of dystonia and developing optimal strategies for DBS.
View article: Establishing the relationship between subjective perception and neural responses: Insights from correlation analysis and representational similarity analysis
Establishing the relationship between subjective perception and neural responses: Insights from correlation analysis and representational similarity analysis Open
Exploring the relationship between sensory perception and brain responses holds important theoretical and clinical implications. However, commonly used methodologies like correlation analysis performed either intra- or inter- individually …
View article: Effects of Adolescent Empathy on Emotional Resilience: The Mediating Role of Depression and Self-Efficacy and the Moderating Effect of Social Activities
Effects of Adolescent Empathy on Emotional Resilience: The Mediating Role of Depression and Self-Efficacy and the Moderating Effect of Social Activities Open
Background: This study aims to investigate the role of empathy in fostering emotional resilience and the impact of social activity on adolescents’ mental health. Methods: A survey was conducted on 1666 adolescents aged from 11 to 15 across…
View article: Cortico-spinal Mechanisms of TENS-induced Analgesia: A Single-Blind, Three-Arm, fMRI-Based Randomized Controlled Trial
Cortico-spinal Mechanisms of TENS-induced Analgesia: A Single-Blind, Three-Arm, fMRI-Based Randomized Controlled Trial Open
Summary Background Transcutaneous Electrical Nerve Stimulation (TENS) is widely used for pain management, yet how different parameters—Conventional (high frequency, low intensity) versus Acupuncture-Like (low frequency, high intensity)—mod…
View article: Distinct neocortical mechanisms underlie human SI responses to median nerve and laser-evoked peripheral activation
Distinct neocortical mechanisms underlie human SI responses to median nerve and laser-evoked peripheral activation Open
Magneto- and/or electro-encephalography (M/EEG) are non-invasive clinically relevant tools that have long been used to measure electromagnetic fields in the somatosensory cortex evoked by innocuous and noxious somatosensory stimuli. Two co…