Lei Ren
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View article: Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses Open
Cancers thrive on neuronal input. Here, we demonstrate the presence of pseudo-synaptic connections between sensory nerve endings and cancer cells in an extracerebral cancer, i.e., pancreatic ductal adenocarcinoma (PDAC). These synaptic sit…
View article: Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery
Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery Open
Gut biological information, including microbiota and metabolites, shows increasing associations with diseases such as inflammatory bowel disease, obesity, and diabetes. Precise sampling and modulation of biological information have become …
View article: Swelling behavior observation of gel resin in heavy metal adsorption process: gel resin containing sodium carboxylate
Swelling behavior observation of gel resin in heavy metal adsorption process: gel resin containing sodium carboxylate Open
In previous researches, the adsorption process of gel resin has been described as ion exchange process. The strong hydrophilic and quick ionization property of -COONa group in solution have not been considered. Thus, this article aimed to …
View article: Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma
Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma Open
Lung cancer remains the leading cause of malignant tumors worldwide in terms of the incidence and mortality, posing a significant threat to human health. Given that distant metastases typically occur at the time of initial diagnosis, leadi…
View article: Chlamydomonas-Inspired Water-Air Interface Mini-Robot with Intricate Tectonics, Programmable Locomotion, and Multifunctional Execution
Chlamydomonas-Inspired Water-Air Interface Mini-Robot with Intricate Tectonics, Programmable Locomotion, and Multifunctional Execution Open
With the rapid development of micro-robotics, non-mechanical stimulus-responsive water-air interface mini-robots have become a prominent focus in intelligent materials and environmentally responsive systems. However, their versatile applic…
View article: Computer‐Aided Technology for Bioactive Protein Design and Clinical Application
Computer‐Aided Technology for Bioactive Protein Design and Clinical Application Open
Computer‐aided protein design (CAPD) has become a transformative field, harnessing advances in computational power and deep learning to deepen the understanding of protein structure, function, and design. This review provides a comprehensi…
View article: Ecological Shifts and Functional Adaptations of Soil Microbial Communities Under Petroleum Hydrocarbon Contamination
Ecological Shifts and Functional Adaptations of Soil Microbial Communities Under Petroleum Hydrocarbon Contamination Open
Petroleum hydrocarbon contamination has emerged as a significant global environmental issue, severely impacting soil microbial communities and their functions. This study employed high-throughput sequencing to systematically analyze the ba…
View article: Gold Nanoparticles Enhance TRAIL Sensitivity Through Drp1-Mediated Apoptotic and Autophagic Mitochondrial Fission in NSCLC Cells [Retraction]
Gold Nanoparticles Enhance TRAIL Sensitivity Through Drp1-Mediated Apoptotic and Autophagic Mitochondrial Fission in NSCLC Cells [Retraction] Open
[This retracts the article DOI: 10.2147/IJN.S129274.].
View article: Tough, High-Strength and Recyclability Polyurethane Elastomers Via Woven Crosslinking Strategy
Tough, High-Strength and Recyclability Polyurethane Elastomers Via Woven Crosslinking Strategy Open
View article: The neural plasticity and efficacy of acupuncture for post-stroke dysphagia: protocol for a randomized controlled trial with fMRI and DTI
The neural plasticity and efficacy of acupuncture for post-stroke dysphagia: protocol for a randomized controlled trial with fMRI and DTI Open
Chinese Clinical Trial Registry ( www.chictr.org.cn ) ChiCTR2300067480. This study was registered on 9th January 2023.
View article: Investigations into dynamic variation characteristics of near-bottom boundary flows over a long term at strait areas
Investigations into dynamic variation characteristics of near-bottom boundary flows over a long term at strait areas Open
Dynamic processes at the bottom boundary layers are crucial for various marine applications such as marine energy exploration and environmental protection. This paper explored hydrodynamic characteristics of near-bottom boundary currents b…
View article: Tissue engineering strategies for spiral ganglion neuron protection and regeneration
Tissue engineering strategies for spiral ganglion neuron protection and regeneration Open
View article: Editorial: Reducing healthcare-associated infections through antimicrobial materials
Editorial: Reducing healthcare-associated infections through antimicrobial materials Open
International audience
View article: ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair
ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair Open
Reactive oxygen species (ROS) plays important roles in living organisms. While ROS is a double-edged sword, which can eliminate drug-resistant bacteria, but excessive levels can cause oxidative damage to cells. A core–shell nanozyme, CeO 2…
View article: Effect of Submerged Entry Nozzle Structure on Fluid Flow, Slag Entrainment, and Solidification Process in a Slab Continuous Casting Mold
Effect of Submerged Entry Nozzle Structure on Fluid Flow, Slag Entrainment, and Solidification Process in a Slab Continuous Casting Mold Open
The fluid flow and slag entrainment in a slab continuous casting mold were investigated by establishing a full-scale water model. Meanwhile, the heat transfer and solidification process of liquid steel in the mold were studied through nume…
View article: Distribution characteristics and assessment of wind energy resources in the coastal areas of Guangdong
Distribution characteristics and assessment of wind energy resources in the coastal areas of Guangdong Open
In order to improve the efficiency, availability and economy during construction and operation of wind farms, characteristic analysis and evaluation of the regional wind energies are key components. In this paper, wind energy resource eval…
View article: Automated surface profile measurement with digital holographic microscopy and large mask inpainting networks
Automated surface profile measurement with digital holographic microscopy and large mask inpainting networks Open
Digital holographic microscopy (DHM) allows for highly precise 3D surface measurements in a non-invasive way, but phase aberrations from off-axis DHM recordings can compromise image accuracy. Traditional compensation methods require manual…
View article: Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion
Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion Open
Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled i…
View article: Driving modes and characteristics of biomedical micro-robots
Driving modes and characteristics of biomedical micro-robots Open
Micro-robots (MRs) are miniature machines with dimensions smaller than 1 mm and have semi- or fully-autonomous capabilities, including sensing, decision-making, and performing operations. These MRs have garnered significant attention in th…
View article: Poly(pentahydropyrimidine)‐Based Hybrid Hydrogel with Synergistic Antibacterial and Pro‐Angiogenic Ability for the Therapy of Diabetic Foot Ulcers
Poly(pentahydropyrimidine)‐Based Hybrid Hydrogel with Synergistic Antibacterial and Pro‐Angiogenic Ability for the Therapy of Diabetic Foot Ulcers Open
Bacterial infection and impaired angiogenesis make the treatment of diabetic foot ulcers (DFU) extremely challenging. Cationic polymers are expected to treat infected wounds due to their excellent antibacterial properties, but still, it is…
View article: Arterial Resection for Pancreatic Cancer: Feasibility and Current Standing in a High-Volume Center
Arterial Resection for Pancreatic Cancer: Feasibility and Current Standing in a High-Volume Center Open
Background: Arterial resection (AR) during pancreatectomy for curative R0 resection of pancreatic ductal adenocarcinoma (PDAC) remains a controversial procedure with high morbidity. Objective: To investigate the feasibility and oncological…
View article: Ground-based and additional science support for SMILE
Ground-based and additional science support for SMILE Open
The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field …
View article: Revolutionizing Porous Liquids: Stabilization and Structural Engineering Achieved by a Surface Deposition Strategy
Revolutionizing Porous Liquids: Stabilization and Structural Engineering Achieved by a Surface Deposition Strategy Open
Facile approaches capable of constructing stable and structurally diverse porous liquids (PLs) that can deliver high‐performance applications are a long‐standing, captivating, and challenging research area that requires significant attenti…
View article: Towards Point of Care CRISPR-Based Diagnostics: From Method to Device
Towards Point of Care CRISPR-Based Diagnostics: From Method to Device Open
Rapid, accurate, and portable on-site detection is critical in the face of public health emergencies. Infectious disease control and public health emergency policymaking can both be aided by effective and trustworthy point of care tests (P…
View article: Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing
Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing Open
The spinal cord possesses highly complex, finely organized cytoarchitecture guided by two dorsoventral morphogenic organizing centers. Thus, generation of human spinal cord tissue in vitro is challenging. Here, we demonstrated a nov…
View article: Study on Wake of a Yawed Square Cylinder Using Particle Image Velocimetry
Study on Wake of a Yawed Square Cylinder Using Particle Image Velocimetry Open
The wake of a yawed square cylinder undergoing steady flow was examined by employing particle image velocimetry (PIV) technique. The present study is concerned with the independence principle (IP) for a square cylinder by examining the eff…
View article: Characterizing wind fields at multiple temporal scales: A case study of the adjacent sea area of Guangdong–Hong Kong–Macao Greater Bay Area
Characterizing wind fields at multiple temporal scales: A case study of the adjacent sea area of Guangdong–Hong Kong–Macao Greater Bay Area Open
Temporal characteristics and evolutionary patterns of offshore wind fields directly affect the stability and safety of coastal engineering and structures. In this research, ECMWF-ERA5 reanalysis wind field data were used to analyze the win…
View article: Investigations into mode characteristics of wind fields off the Guangdong coast using Empirical Orthogonal Function
Investigations into mode characteristics of wind fields off the Guangdong coast using Empirical Orthogonal Function Open
As one of the clean and renewable energy sources, wind energy has received increasing attentions from the public in recent years. Large-scale investigations into wind speeds and directions can provide guidance and reference for regional wi…
View article: Investigation into spatiotemporal characteristics of coastal winds around the Taiwan Island
Investigation into spatiotemporal characteristics of coastal winds around the Taiwan Island Open
Temporal and spatial variation characteristics of winds and their relationship with terrain environment in the Taiwan Island were investigated in this research. Based on the empirical orthogonal function (EOF) analysis, the monthly-average…
View article: Analysis on distribution characteristics of velocities over depth in a coastal area
Analysis on distribution characteristics of velocities over depth in a coastal area Open