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View article: Uranium’s hazardous effects on humans and recent developments in treatment
Uranium’s hazardous effects on humans and recent developments in treatment Open
Uranium, a naturally occurring element, is predominantly recognized for its role as fuel in both civilian and military energy sectors. Concerns have been raised regarding the adverse environmental impacts and health risks associated with u…
View article: Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis
Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis Open
View article: A low-toxicity uranyl-selective-binding linear pentapeptide sequence as a potential uranium decorporation agent
A low-toxicity uranyl-selective-binding linear pentapeptide sequence as a potential uranium decorporation agent Open
A phosphorylated short straight-chain polypeptide has been synthesized and demonstrates high selectivity and efficiency as a low-toxicity chelating agent for uranium decorporation in vivo .
View article: Structural basis of three different transcription activation strategies adopted by a single regulator SoxS
Structural basis of three different transcription activation strategies adopted by a single regulator SoxS Open
Transcription activation is established through extensive protein–protein and protein–DNA interactions that allow an activator to engage and remodel RNA polymerase. SoxS, a global transcription activator, diversely regulates subsets of str…
View article: Structural and mechanistic basis of reiterative transcription initiation
Structural and mechanistic basis of reiterative transcription initiation Open
Significance In standard transcription initiation, RNA polymerase (RNAP) synthesizes an initial RNA product complementary to the DNA template. In an alternative pathway of transcription initiation, termed “reiterative transcription initiat…
View article: Structural basis of transcription activation by the global regulator Spx
Structural basis of transcription activation by the global regulator Spx Open
Spx is a global transcriptional regulator in Gram-positive bacteria and has been inferred to efficiently activate transcription upon oxidative stress by engaging RNA polymerase (RNAP) and promoter DNA. However, the precise mechanism by whi…
View article: TiO2 Nanowire Arrays in situ Grown on Ti Foil Exhibiting Superior Uranyl-Adsorption Properties
TiO2 Nanowire Arrays in situ Grown on Ti Foil Exhibiting Superior Uranyl-Adsorption Properties Open
TiO 2 nanowire arrays in situ grown on Ti foil (TiO 2 /Ti) were prepared to remove uranium (VI) from aqueous solution. As the Ti foil serves as a carrier for TiO 2 , the TiO 2 /Ti adsorbent can be effortlessly retrieved from aqueous soluti…
View article: The mechanism of variability in transcription start site selection
The mechanism of variability in transcription start site selection Open
During transcription initiation, RNA polymerase (RNAP) binds to promoter DNA, unwinds promoter DNA to form an RNAP-promoter open complex (RPo) containing a single-stranded ‘transcription bubble,’ and selects a transcription start site (TSS…
View article: Author response: The mechanism of variability in transcription start site selection
Author response: The mechanism of variability in transcription start site selection Open
Article Figures and data Abstract eLife digest Introduction Results and discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract During transcription initiation, RNA polyme…
View article: The mechanism of transcription start site selection
The mechanism of transcription start site selection Open
SUMMARY During transcription initiation, RNA polymerase (RNAP) binds to promoter DNA, unwinds promoter DNA to form an RNAP-promoter open complex (RPo) containing a single-stranded "transcription bubble," and selects a transcription start s…
View article: New reactions and strategies in divergent syntheses of macrolide antibiotics
New reactions and strategies in divergent syntheses of macrolide antibiotics Open
From the microbial world, antibiotics are structurally complex and highly potent chemical weapons that co-evolved with bacteria. Macrolide (glycosylated cyclic polyketides) antibiotics have been used extensively as first-line antibacterial…