Explanipedia

A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology Open

Michaela T. Reichmann, Liku B. Tezera, Laura Denney, Hannah Schiff, Andrés F. Vallejo , et al. · 2025

Tuberculosis is once again the most fatal global infectious disease and has killed many more humans than any other pathogen. Despite the identification of Mycobacterium tuberculosis (Mtb) over 140 years ago, we have yet to control the epid…

A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology Open

Michaela T. Reichmann, Liku B. Tezera, Laura Denney, Hannah Schiff, Andrés F. Vallejo , et al. · 2025

Tuberculosis is once again the most fatal global infectious disease and has killed many more humans than any other pathogen. Despite the identification of Mycobacterium tuberculosis (Mtb) over 140 years ago, we have yet to control the epid…

Author response: A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology Open

Michaela T. Reichmann, Liku B. Tezera, Laura Denney, Hannah Schiff, Andrés F. Vallejo , et al. · 2025

A Co-evolutionary Perspective on Humans and Mycobacterium Tuberculosis in the Era of Systems Biology Open

Paul Elkington, Liku B. Tezera, Michaela T. Reichmann, Alasdair Leslie, Laura Denney , et al. · 2025

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles Open

Robert Krause, Paul Ogongo, Liku B. Tezera, Mohammed Ahmed, Ian Mbano , et al. · 2024

Three-Dimensional Culture Modelling Reveals Divergent Mycobacterium tuberculosis Virulence and Antimicrobial Treatment Response Open

Magdalena K. Bielecka, Liku B. Tezera, Elena Konstantinopoulou, Nicola Casali, Orestis L. Katsamenis , et al. · 2024

Tuberculosis (TB) remains a persistent epidemic, and the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) presents a global healthcare threat. While some new agents have been successfully introduced, innovative technologies to …

An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis Open

Rachel L. Paterson, Marco Pio La Manna, Victoria Arena De Souza, Andrew Walker, Dawn Gibbs‐Howe , et al. · 2024

Peptides presented by HLA-E, a molecule with very limited polymorphism, represent attractive targets for T cell receptor (TCR)-based immunotherapies to circumvent the limitations imposed by the high polymorphism of classical HLA genes in t…

Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model Open

Mohamed I. M. Ahmed, Liku B. Tezera, Nicholas Herbert, Mark A. Chambers, Michaela T. Reichmann , et al. · 2024

A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by Mycobacterium tuberculosis ( Mtb ). However, pharmaceutical inhibition of T cell immune checkpoint molecules can result in th…

Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers Open

Hannah F. Schiff, Naomi F. Walker, César Ugarte‐Gil, Marc Tebruegge, Antigoni Manousopoulou , et al. · 2024

Novel biomarkers to identify infectious patients transmitting Mycobacterium tuberculosis are urgently needed to control the global tuberculosis (TB) pandemic. We hypothesized that proteins released into the plasma in active pulmonary TB ar…

Single-Cell Profiling Reveals a Role for Tuberculosis-Induced Myofibroblasts in the Immunopathology of Infected Lungs Open

Ian Mbano, Nuo Liu, Marc H. Wadsworth, Mark A. Chambers, Thabo Mpotje , et al. · 2024

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and putative functional roles Open

R. R. Krause, Paul Ogongo, Liku B. Tezera, Mohamed I. M. Ahmed, Ian Mbano , et al. · 2023

B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of TB patients and found they are decreased in the blood and increased …

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10 Open

Mohamed I. M. Ahmed, Jared S. Mackenzie, Liku B. Tezera, Robert Krause, Barry Truebody , et al. · 2022

Anti-Tuberculosis Activity of Three Carbapenems, Clofazimine and Nitazoxanide Using a Novel Ex Vivo Phenotypic Drug Susceptibility Model of Human Tuberculosis Open

Ximena Gonzalo, Magdalena K. Bielecka, Liku B. Tezera, Paul Elkington, Francis Drobniewski · 2022

We evaluated a novel physiological 3-D bioelectrospray model of the tuberculosis (TB) granuloma to test the activity of a known anti-TB drug, clofazimine; three carbapenems with potential activity, including one currently used in therapy; …

Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier Open

Eliza Gil, Cristina Venturini, David Stirling, Carolin T. Turner, Liku B. Tezera , et al. · 2022

Excessive neutrophil extravasation can drive immunopathology, exemplified in pyogenic meningitis caused by Streptococcus pneumoniae infection. Insufficient knowledge of the mechanisms that amplify neutrophil extravasation has limited innov…

The paradox of immune checkpoint inhibition re-activating tuberculosis Open

Mohamed I. M. Ahmed, Liku B. Tezera, Paul Elkington, Alasdair Leslie · 2022

By attenuating T-cell activation, immune checkpoints (ICs) limit optimal anti-tumour responses and IC inhibition (ICI) has emerged as a new therapy for a broad range of cancers. T-cell responses are indispensable to tuberculosis (TB) immun…

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10 Open

Mohamed I. M. Ahmed, Jared S. Mackenzie, Robert Krause, Barry Truebody, Liku B. Tezera , et al. · 2021

Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens and remains a leading cause of death from infectious disease. Interferon-γ (IFN-γ) is a central regulator of the immune defense against Mtb . Several cytokines …

Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets Open

Michaela T. Reichmann, Liku B. Tezera, Andrés F. Vallejo, Milica Vukmirovic, Rui Xiao , et al. · 2021

Tuberculosis (TB) is a persistent global pandemic, and standard treatment for it has not changed for 30 years. Mycobacterium tuberculosis (Mtb) has undergone prolonged coevolution with humans, and patients can control Mtb even after extens…

Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung Open

Paul Ogongo, Liku B. Tezera, Amanda Ardain, Shepherd Nhamoyebonde, Duran Ramsuran , et al. · 2021

T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood cells. Mounting evidence, however, indicates that tissue-resident memory T cells…

Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis Open

Diana J. Garay‐Baquero, Cory White, Naomi F. Walker, Marc Tebruegge, Hannah F. Schiff , et al. · 2020

BACKGROUNDTuberculosis (TB) kills more people than any other infection, and new diagnostic tests to identify active cases are required. We aimed to discover and verify novel markers for TB in nondepleted plasma.METHODSWe applied an optimiz…

Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α Open

Liku B. Tezera, Magdalena K. Bielecka, Paul Ogongo, Naomi F. Walker, Matthew Ellis , et al. · 2020

Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al., 2017a). Here, we use the model to investigate mechanisms whe…

Author response: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α Open

Liku B. Tezera, Magdalena K. Bielecka, Paul Ogongo, Naomi F. Walker, Matthew Ellis , et al. · 2020

Reconsidering the Optimal Immune Response to Mycobacterium tuberculosis Open

Liku B. Tezera, Salah Mansour, Paul Elkington · 2019

The global death toll from tuberculosis (TB) is an ongoing tragedy (1). Currently, clinicians in TB-prevalent resource-poor settings attempt to control the pandemic with clearly inadequate tools: bacillus Calmette-Guérin (BCG) vaccination,…

CD1b-restricted GEM T cell responses are modulated byMycobacterium tuberculosismycolic acid meromycolate chains Open

Andrew Chancellor, Anna S. Tocheva, Chris Cave-Ayland, Liku B. Tezera, Andrew White , et al. · 2017

Significance Tuberculosis is a major global pandemic responsible for more deaths than any other infectious disease, yet no effective vaccine exists. Here, we demonstrate CD1b expression within human tuberculous granulomas, supporting a rol…

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology Open

Patience Brace, Liku B. Tezera, Magdalena K. Bielecka, Toby Mellows, Diana J. Garay‐Baquero , et al. · 2017

Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. W…

Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection Open

Andrew Chancellor, Andrew White, Anna S. Tocheva, Joe Fenn, Mike Dennis , et al. · 2017

Matrix Degradation in Human Immunodeficiency Virus Type 1–Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study Open

Naomi F. Walker, Katalin A. Wilkinson, Graeme Meintjes, Liku B. Tezera, René Goliath , et al. · 2017

MMP activity in TB differs by HIV-1 status and compartment, and releases matrix degradation products. Matrix turnover in HIV-1-infected patients is increased before and during TB-IRIS, informing novel diagnostic strategies. MMP inhibition …

A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis Open

Magdalena K. Bielecka, Liku B. Tezera, Robert Zmijan, Francis Drobniewski, Xunli Zhang , et al. · 2017

Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluid…

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model Open

Liku B. Tezera, Magdalena K. Bielecka, Andrew Chancellor, Michaela T. Reichmann, Basim R. Al Shammari , et al. · 2017

Cell biology differs between traditional cell culture and 3-dimensional (3-D) systems, and is modulated by the extracellular matrix. Experimentation in 3-D presents challenges, especially with virulent pathogens. Mycobacterium tuberculosis…

Author response: Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model Open

Liku B. Tezera, Magdalena K. Bielecka, Andrew Chancellor, Michaela T. Reichmann, Basim R. Al Shammari , et al. · 2016

Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Cell biology differs between traditional cell culture and 3-…

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit Open

Alison R Hill, Jessica Donaldson, Cornelia Blume, Natalie P. Smithers, Liku B. Tezera , et al. · 2016

The bronchial epithelium and underlying fibroblasts form an epithelial mesenchymal trophic unit (EMTU) which controls the airway microenvironment. We hypothesized that cell-cell communication within the EMTU propagates and amplifies the in…

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