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View article: Unraveling the Genetic Links Between Polycystic Kidney Disease and Hypertension Through ARL13B
Unraveling the Genetic Links Between Polycystic Kidney Disease and Hypertension Through ARL13B Open
Our bidirectional MR study demonstrated a causal effect of PKD on hypertension and a reverse influence of hypertension on PKD progression. Elevated ARL13B expression in ADPKD suggested a possible involvement of cilia-related pathways in th…
View article: #2056 Effect of individualized dialysate bicarbonate concentration on patient prognosis: a multicenter retrospective study
#2056 Effect of individualized dialysate bicarbonate concentration on patient prognosis: a multicenter retrospective study Open
Background and Aims Higher dialysate bicarbonate is associated with an increased risk of mortality in maintenance hemodialysis patients, and the optimal dialysate bicarbonate regimen is unclear. The aim of this study was to investigate whe…
View article: Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy
Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy Open
View article: Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence
Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence Open
Background Chronic kidney disease (CKD) is a progressive disorder characterized by declining renal function and systemic metabolic disturbances. Brain-derived neurotrophic factor (BDNF), a key member of the neurotrophic family, plays criti…
View article: Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation Open
Introduction Drug-induced cardiotoxicity (DICT), defined as myocardial injury caused by direct or indirect toxicity of therapeutic agents, disrupts cardiovascular homeostasis, underscoring the urgent need for preventive strategies in clini…
View article: Corrigendum to: Diagnostic Value of 3.0 T Magnetic Resonance Imaging in Active Crohn's Disease
Corrigendum to: Diagnostic Value of 3.0 T Magnetic Resonance Imaging in Active Crohn's Disease Open
The authors requested to correct the affiliations in their article titled “Diagnostic Value of 3.0 T Magnetic Resonance Imaging in Active Crohn's Disease,” published in “Current Medical Imaging,” Journal, 2024; 20: e15734056267653 [1]. W…
View article: Correlation between intradialytic blood pressure variability and cognitive impairment in patients on maintenance hemodialysis
Correlation between intradialytic blood pressure variability and cognitive impairment in patients on maintenance hemodialysis Open
Our study found that high SBP ARV was closely associated with MCI, indicating that high SBP ARV may act as an indicator of MCI in MHD patients.
View article: In vivo study on IL-37 inhibition of malignant melanoma metastasis.
In vivo study on IL-37 inhibition of malignant melanoma metastasis. Open
IL-37 significantly inhibits lung metastasis of malignant melanoma cells in mice without affecting body weight or major organs. It may serve as a potential molecular target for gene therapy or immunotherapy of malignant melanoma.
View article: Screening method and metabolic analysis of plant anti-aging microorganisms via ammonia-induced senescence in the duckweed Wolffia microscopica
Screening method and metabolic analysis of plant anti-aging microorganisms via ammonia-induced senescence in the duckweed Wolffia microscopica Open
Ammonium is the preferred N nutrition over nitrate for some plant species, but it is toxic to many other plant species and induces senescence at high concentrations. The duckweed Wolffia microscopica (Griff.) Kurz is the smallest and fast-…
View article: EZH2 inhibition or genetic ablation suppresses cyst growth in autosomal dominant polycystic kidney disease
EZH2 inhibition or genetic ablation suppresses cyst growth in autosomal dominant polycystic kidney disease Open
View article: Diagnostic Value of 3.0 T Magnetic Resonance Imaging in Active Crohn'sDisease
Diagnostic Value of 3.0 T Magnetic Resonance Imaging in Active Crohn'sDisease Open
Background:: Magnetic resonance enteroclysis (MRE) has been widely applied to diagnose Crohn’s disease (CD). Magnetic resonance (MR) at 3.0 T improves signal-to-noise ratio (SNR), shortens image acquisition time, and shows more advantages.…
View article: Inflammation Is More Sensitive than Cell Proliferation in Response to Rapamycin Treatment in Polycystic Kidney Disease
Inflammation Is More Sensitive than Cell Proliferation in Response to Rapamycin Treatment in Polycystic Kidney Disease Open
Introduction: It has been reported that rapamycin inhibited inflammation in renal interstitial diseases. We therefore hypothesized that rapamycin could attenuate inflammation in polycystic kidney disease (PKD). Methods:…
View article: Influencing factors of bladder temperature measured by temperature-sensing urinary catheter in patients with massive burns
Influencing factors of bladder temperature measured by temperature-sensing urinary catheter in patients with massive burns Open
Objective To analyze the influencing factors of bladder temperature measured by temperature-sensing urinary catheter in patients with massive burns. Methods The clinical data of 500 times of bladder temperature measurement in 20patients wi…
View article: Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis
Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis Open
Numerous studies have proven the critical role of macrophages in the renal fibrosis process. Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has been shown to play a ubiquitous role in regulating macropha…
View article: Counterintuitive relationship between the triglyceride glucose index and diabetic foot in diabetes patients: A cross-sectional study
Counterintuitive relationship between the triglyceride glucose index and diabetic foot in diabetes patients: A cross-sectional study Open
Background Research has shown that insulin resistance (IR) is a known risk factor for diabetic foot (DF), and the triglyceride-glucose (TyG) index is a reliable and simple indicator of IR. However, less is known about the relationship betw…
View article: Comparison of the Immune Responses to Different Formulations of BC02-Adjuvanted HPV Types 16 and 18 Bivalent Vaccines in Mice
Comparison of the Immune Responses to Different Formulations of BC02-Adjuvanted HPV Types 16 and 18 Bivalent Vaccines in Mice Open
To achieve maximum efficacy, vaccines, such as subunit, recombinant, and conjugate vaccines, necessitate the incorporation of immunostimulators/adjuvants. Adjuvants play a vital role in bolstering and extending the strength of the immune r…
View article: Use of body weight-adjusted FEV1/FVC as an index to predict the risk of sarcopenia among elderly people in the community
Use of body weight-adjusted FEV1/FVC as an index to predict the risk of sarcopenia among elderly people in the community Open
Background The quality and function of skeletal muscle decrease with aging in humans. Meanwhile, sarcopenia leads to increased fat mass and decreased muscle mass in the elderly. Furthermore, sarcopenia results in decreased respiratory musc…
View article: Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice
Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice Open
View article: Structural basis for FGF hormone signalling
Structural basis for FGF hormone signalling Open
View article: Automatic Segmentation of Kidney Volume Using Multi-Module Hybrid Based U-Shape in Polycystic Kidney Disease
Automatic Segmentation of Kidney Volume Using Multi-Module Hybrid Based U-Shape in Polycystic Kidney Disease Open
Polycystic kidney disease (Autosomal Dominant Polycystic Kidney Disease, ADPKD) is the most common genetic disease of the kidney, and the measurement of Total Kidney Volume (TKV) in clinical research of this disease is essential to study t…
View article: Urine biomarkers can outperform serum biomarkers in certain diseases
Urine biomarkers can outperform serum biomarkers in certain diseases Open
Urinary biomarkers offer a non-invasive and easily accessible means of assessing an individual's health and susceptibility to various diseases. They can provide critical insights into an individual's predisposition to certain conditions, d…
View article: Upregulation of WDR6 Drives Hepatic de novo Lipogenesis in Insulin Resistance
Upregulation of WDR6 Drives Hepatic de novo Lipogenesis in Insulin Resistance Open
Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during insulin resistance (IR), when insulin signaling is blunted and accompanied by hyperinsulinemia, the promotion of hepatic DNL continues unabated an…
View article: Relationship between Dialysate Bicarbonate Concentration and All-Cause Mortality in Hemodialysis Patients
Relationship between Dialysate Bicarbonate Concentration and All-Cause Mortality in Hemodialysis Patients Open
Introduction: The optimal dialysate bicarbonate concentration (DBIC) for hemodialysis (HD) remains controversial. Herein, we analyzed the effect of dialysate bicarbonate levels on mortality in HD patients. Methods:<…
View article: Novel BC02 Compound Adjuvant Enhances Adaptive and Innate Immunity Induced by Recombinant Glycoprotein E of Varicella-Zoster Virus
Novel BC02 Compound Adjuvant Enhances Adaptive and Innate Immunity Induced by Recombinant Glycoprotein E of Varicella-Zoster Virus Open
Both adaptive and innate immunity responses are necessary for the efficient elimination of different pathogens. However, the magnitude, quality and desired type of immune response specific to the co-administered antigen is largely determin…
View article: Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins
Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins Open
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel. However, how ANO1 …
View article: In-center Nocturnal Hemodialysis Reduced the Circulating FGF23, Left Ventricular Hypertrophy, and All-Cause Mortality: A Retrospective Cohort Study
In-center Nocturnal Hemodialysis Reduced the Circulating FGF23, Left Ventricular Hypertrophy, and All-Cause Mortality: A Retrospective Cohort Study Open
Fibroblast growth factor 23(FGF23) is the most important biomarker and pathogenic factor in Chronic Kidney Disease–Mineral and Bone Disorder (CKD–MBD). In the moderate and severe stages of chronic renal failure, abnormally elevated circula…
View article: Enhanced Potency and Persistence of Immunity to Varicella-Zoster Virus Glycoprotein E in Mice by Addition of a Novel BC02 Compound Adjuvant
Enhanced Potency and Persistence of Immunity to Varicella-Zoster Virus Glycoprotein E in Mice by Addition of a Novel BC02 Compound Adjuvant Open
Herpes zoster (HZ) is one of two distinct syndromes caused by Varicella-zoster virus (VZV). A primary infection with VZV causes varicella in susceptible young children. After resolution of the primary infection, VZV establishes a lifelong …
View article: Sika Deer Facial Recognition Model Based on SE-ResNet
Sika Deer Facial Recognition Model Based on SE-ResNet Open
The scale of deer breeding has gradually increased in recent years and better information management is necessary, which requires the identification of individual deer. In this paper, a deer face dataset is produced using face images obtai…
View article: Icariin attenuates renal interstitial fibrosis through G protein-coupled estrogen receptor in a UUO murine model.
Icariin attenuates renal interstitial fibrosis through G protein-coupled estrogen receptor in a UUO murine model. Open
Our findings indicate that (1) GPER inhibition exacerbates renal fibrosis, and (2) icariin exerts antifibrotic effects against renal fibrosis through GPER.
View article: miR-199b-3p Promotes Radiation-induced Oral Mucositis via DDIT4-mediated mTOR Signal Pathway
miR-199b-3p Promotes Radiation-induced Oral Mucositis via DDIT4-mediated mTOR Signal Pathway Open
Background: Radiation-induced oral mucositis (RIOM) is an adverse reaction in patients of head and neck cancer after radiotherapy. However, the key regulatory factors in the pathogenesis of RIOM remain largely unclear. In this article, we …