Liliana Schaefer
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View article: Inhibition of FXIIa attenuates kidney fibrosis in mice with unilateral ureteral obstruction
Inhibition of FXIIa attenuates kidney fibrosis in mice with unilateral ureteral obstruction Open
Kidney fibrosis is a common manifestation of chronic kidney diseases, with parenchymal tissue scarring serving as a histologic predictor of functional deterioration. Considering the relationships between contact-phase system activation and…
View article: Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl2
Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl2 Open
The cellular and tissue response to acute hypoxia is mediated by a complex adaptive response initiated by hypoxia-inducible factors (HIF) 1 and 2. HIF proteins are key transcription factors that modulate gene expression to adapt cells to t…
View article: Artificial Intelligence-Based Comparison of Duodenojejunostomy and Sleeve Gastrectomy on Pancreatic Morphology in Zucker Diabetic Fatty Rats
Artificial Intelligence-Based Comparison of Duodenojejunostomy and Sleeve Gastrectomy on Pancreatic Morphology in Zucker Diabetic Fatty Rats Open
Introduction Obesity and type 2 diabetes mellitus (T2D) are interrelated metabolic disorders with increasing global incidence. Bariatric surgeries such as sleeve gastrectomy (SG) and Roux-en Y gastric bypass (RYGB) improve glycemic control…
View article: Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice Open
Having identified LC3-interacting region (LIR) motifs 1/2 of A20 binding inhibitor of NF-κB-1 (ABIN-1) as mitophagy regulators in vitro, this study generated CRISPR-engineered ABIN1-ΔLIR1/2 mice lacking both LIR motifs to elucidate its in …
View article: Elevated Sphingosine Levels Suppress Profibrotic <scp>TGF</scp> ‐β Signaling via the <scp>PKC</scp> / <scp>miR</scp> ‐21/ <scp>SMAD7</scp> Axis in Sphingosine Kinase 2‐Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction‐Induced Kidney Fibrosis
Elevated Sphingosine Levels Suppress Profibrotic <span>TGF</span> ‐β Signaling via the <span>PKC</span> / <span>miR</span> ‐21/ <span>SMAD7</span> Axis in Sphingosine Kinase 2‐Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction‐Induced Kidney Fibrosis Open
Renal fibrosis is the final pathological outcome of chronic kidney disease and is characterized by an excessive accumulation of extracellular matrix (ECM), leading to tissue dysfunction and, ultimately, organ failure. In this study, we inv…
View article: Tissue factor binds to and inhibits interferon-α receptor 1 signaling
Tissue factor binds to and inhibits interferon-α receptor 1 signaling Open
Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation and coagulation-dependent inflammation. TF also exerts protective effects through unknown mechanisms. Here, we showed that TF bound to interferon-α…
View article: Glycosylation signature of plasma IgA of critically ill COVID-19 patients
Glycosylation signature of plasma IgA of critically ill COVID-19 patients Open
Thromboembolic complications are common in severe COVID-19 and are thought to result from excessive neutrophil-extracellular-trap (NET)-driven immunothrombosis. Glycosylation plays a vital role in the efficiency of immunoglobulin A (IgA) e…
View article: A biological guide to glycosaminoglycans: current perspectives and pending questions
A biological guide to glycosaminoglycans: current perspectives and pending questions Open
Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs). This article summarizes key biological findings for the most widespread GA…
View article: Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer
Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer Open
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stag…
View article: The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells Open
Induction of cell-lethal autophagy represents a possible strategy to combat glioblastoma (GBM). Here, we demonstrate that the novel iron chelator and OXPHOS inhibitor VLX600 exerts pronounced tumor cell-killing effects in adherently cultur…
View article: Global impact of proteoglycan science on human diseases
Global impact of proteoglycan science on human diseases Open
In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biolog…
View article: Decoding the role of fatty acids and their metabolites in lung fibrosis
Decoding the role of fatty acids and their metabolites in lung fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a progressive and life‑threatening interstitial lung disease of familial or sporadic onset. The incidence and prevalence of IPF range from 0.09 to 1.3 and from 0.33 to 4.51 per 10 000 people, respecti…
View article: Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure
Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure Open
Liver cirrhosis is the end stage of all chronic liver diseases and contributes significantly to overall mortality of 2% globally. The age-standardized mortality from liver cirrhosis in Europe is between 10 and 20% and can be explained by n…
View article: The emerging role of extracellular vesicles as communicators between adipose tissue and pathologic lungs with a special focus on asthma
The emerging role of extracellular vesicles as communicators between adipose tissue and pathologic lungs with a special focus on asthma Open
Extracellular vesicles (EVs) gain increasing attention due to their (patho-)physiological role in intercellular signaling, specifically in the communication between distant organs. Recent studies highlight a connection between the adipose …
View article: Biglycan regulates bone development and regeneration
Biglycan regulates bone development and regeneration Open
Endochondral bone development and regeneration relies on activation and proliferation of periosteum derived-cells (PDCs). Biglycan (Bgn), a small proteoglycan found in extracellular matrix, is known to be expressed in bone and cartilage, h…
View article: A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy
A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy Open
TNIP1/ABIN-1 is a novel inhibitor of inflammation and cell death. In our study, we elucidated the MAP1LC3/LC3 (microtubule associated protein 1 light chain 3)-interacting region (LIR) 1 and 2 motifs of TNIP1-dependent direct binding to LC3…
View article: A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy
A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy Open
A20 binding inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1), a polyubiquitin-binding protein, is a signal-induced autophagy receptor that attenuates NF-κB-mediated inflammation and cell death. The present study aimed to elucidate th…
View article: Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy
Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy Open
S1P and its receptors have been reported to play important roles in the development of renal fibrosis. Although S1P5 has barely been investigated so far, there are indications that it can influence inflammatory and fibrotic processes. Here…
View article: The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma
The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma Open
Sphingosine 1‐phosphate (S1P) is a lipid mediator with numerous biological functions. The term ‘S1P’ mainly refers to the sphingolipid molecule with a long‐chain sphingoid base of 18 carbon atoms, d18:1 S1P. The enzyme serine palmitoyltran…
View article: EGFR Signaling in Lung Fibrosis
EGFR Signaling in Lung Fibrosis Open
In this review article, we will first provide a brief overview of the ErbB receptor–ligand system and its importance in developmental and physiological processes. We will then review the literature regarding the role of ErbB receptors and …
View article: Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19 Open
The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. In this study, we determined the altered levels of factor XII (FXII) and its activation products in critically ill patien…
View article: The Role of Decorin and Biglycan Signaling in Tumorigenesis
The Role of Decorin and Biglycan Signaling in Tumorigenesis Open
The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteogly…
View article: The basement membrane in the cross-roads between the lung and kidney
The basement membrane in the cross-roads between the lung and kidney Open
The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney…
View article: Altered fibrin clot structure contributes to thrombosis risk in severe COVID-19
Altered fibrin clot structure contributes to thrombosis risk in severe COVID-19 Open
The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. Here, we demonstrate altered levels of factor XII (FXII) and its activation products in two independent cohorts of critic…