Lilin Wang
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View article: Transcriptomics and metabolomics analysis reveals cell subpopulations of trophoblast cells associated with preeclampsia
Transcriptomics and metabolomics analysis reveals cell subpopulations of trophoblast cells associated with preeclampsia Open
Placental abnormalities are central to preeclampsia (PE), yet the cellular and molecular mechanisms underlying this dysfunction remain unclear. We applied a multi-layered, integrative approach to investigate placental tissue from PE patien…
View article: Achieving high-density oxides and superior high-temperature properties in additively manufactured superalloys via precise oxygen control
Achieving high-density oxides and superior high-temperature properties in additively manufactured superalloys via precise oxygen control Open
To further increase dispersoid number density in oxide dispersion strengthened (ODS) alloys fabricated by laser powder bed fusion (L-PBF), this study employs a precise oxygen-controlled treatment of Y-alloyed Hastelloy X powders, eliminati…
View article: <scp>METTL14</scp> Inhibits Human Lung Microvascular Endothelial Cell From Ferroptosis in Septic Lung Injury by Regulating <scp> N <sup>6</sup> </scp> ‐Methyladenosine‐Modified <scp>ACSL4</scp> Level
<span>METTL14</span> Inhibits Human Lung Microvascular Endothelial Cell From Ferroptosis in Septic Lung Injury by Regulating <span> N <sup>6</sup> </span> ‐Methyladenosine‐Modified <span>ACSL4</span> Level Open
Background N 6 ‐methyladenosine (m 6 A) RNA modification is involved in numerous physiological and pathological processes. However, the specific role of m 6 A modification in septic lung injury remains unknown. Methods Here, caecal ligatio…
View article: Effects of Tai Chi combined with intermediate frequency therapy on patients with chronic nonspecific neck pain: a randomized controlled trial
Effects of Tai Chi combined with intermediate frequency therapy on patients with chronic nonspecific neck pain: a randomized controlled trial Open
Background Chronic non-specific neck pain (CNSNP) is the most common type of chronic neck pain encountered in clinical practice. Existing studies have demonstrated that intermediate frequency therapy can effectively alleviate neck pain sym…
View article: Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study
Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study Open
The combination of ICIs and AAs showed favorable clinical benefits, safety and tolerability in uHCC patients with CP B cirrhosis, with some patients experiencing improvements in Child-Pugh score. More well-designed studies with larger samp…
View article: Metagenomics and In Vitro Growth-Promoting Experiments Revealed the Potential Roles of Mycorrhizal Fungus Humicolopsis cephalosporioides and Helper Bacteria in Cheilotheca humilis Growth
Metagenomics and In Vitro Growth-Promoting Experiments Revealed the Potential Roles of Mycorrhizal Fungus Humicolopsis cephalosporioides and Helper Bacteria in Cheilotheca humilis Growth Open
In mycorrhizal symbiotic relationships, non-photosynthetic myco-heterotrophic plants are unable to supply photosynthates to their associated fungi. On the contrary, they rely on fungal carbon to sustain their own growth. Mycorrhizal fungi …
View article: Time-Course Transcriptome, Metabolome, and Weighted Gene Co-Expression Network Analysis Reveal the Roles of the OsBELH4A Gene in Regulating Leaf Senescence and Grain Yield of Rice
Time-Course Transcriptome, Metabolome, and Weighted Gene Co-Expression Network Analysis Reveal the Roles of the OsBELH4A Gene in Regulating Leaf Senescence and Grain Yield of Rice Open
Rice (Oryza sativa L.) is one of the major food crops. Yield and quality are affected by premature leaf senescence, a complex and tightly regulated developmental process. To elucidate the molecular regulatory mechanism controlling rice lea…
View article: A co-evolving agentic AI system for medical imaging analysis
A co-evolving agentic AI system for medical imaging analysis Open
Agentic AI is rapidly advancing in healthcare and biomedical research. However, in medical image analysis, their performance and adoption remain limited due to the lack of a robust ecosystem, insufficient toolsets, and the absence of real-…
View article: Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study
Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study Open
Background Immune checkpoint inhibitors (ICIs) combined with antiangiogenic agents (AAs) have been recommended as the first-line systemic treatment for unresectable hepatocellular carcinoma (uHCC). However, most Phase III clinical trials h…
View article: CRISPR/Cas9-mediated editing of barley lipoxygenase genes promotes grain fatty acid accumulation and storability
CRISPR/Cas9-mediated editing of barley lipoxygenase genes promotes grain fatty acid accumulation and storability Open
Plant lipoxygenases (LOXs) catalyze the oxidation of polyunsaturated fatty acids, which can adversely affect grain storability. Although the genetic engineering of LOXs holds great potential for improving grain storage quality, this approa…
View article: Role of mitochondria in physiological activities, diseases, and therapy
Role of mitochondria in physiological activities, diseases, and therapy Open
Mitochondria are generally considered essential for life in eukaryotic organisms because they produce most of the energy or adenosine triphosphate (ATP) needed by the cell. Beyond energy production, it is now widely accepted that mitochond…
View article: CyTOF reveals platelet subtype changes predicting the efficacy of combined immunotherapy and targeted therapy in liver cancer
CyTOF reveals platelet subtype changes predicting the efficacy of combined immunotherapy and targeted therapy in liver cancer Open
Introduction Immune checkpoint inhibitors combined with angiogenesis inhibitors are currently the first-line treatment for liver cancer. However, some patients still exhibit poor therapeutic outcomes. Platelets, as a critical component of …
View article: Highly heterozygous Citrus changshan-huyou Y. B. Chang originated from ancient hybridization between mandarin and pummelo and displayed distinct tissue-specific allelic imbalance
Highly heterozygous Citrus changshan-huyou Y. B. Chang originated from ancient hybridization between mandarin and pummelo and displayed distinct tissue-specific allelic imbalance Open
Citrus is an interesting model for plant genome evolution study due to its reticulate evolutionary history with frequent hybridization. Citrus changshan Y. B. Chang (Huyou) is a unique landrace first discovered in Zhejiang Province, China …
View article: Achieving strength-plasticity synergy in trace B-modified near β titanium alloy fabricated by laser directed energy deposition
Achieving strength-plasticity synergy in trace B-modified near β titanium alloy fabricated by laser directed energy deposition Open
Achieving a balance between strength and ductility in additively manufactured near β titanium alloys is challenging. In this study, adding trace B to Ti-5Al-5Mo-5V-3Cr-1Zr significantly enhanced constitutional undercooling and suppressed g…
View article: Effect of powder-feeding process on metal transfer mode and microstructural evolution of wire–powder–arc directed energy deposition-manufactured aluminum alloys
Effect of powder-feeding process on metal transfer mode and microstructural evolution of wire–powder–arc directed energy deposition-manufactured aluminum alloys Open
Wire–powder–arc directed energy deposition (WPA-DED) technology offers significant potential for alloy development and the production of large, complex-graded material parts due to its capability for in situ deposit composition adjustment.…
View article: Optimizing deoxidizer in maraging steel for additive manufacturing: Impact on oxide refinement and impact toughness
Optimizing deoxidizer in maraging steel for additive manufacturing: Impact on oxide refinement and impact toughness Open
The high oxygen content in additive manufacturing powders (up to 100 ppm) significantly increases oxide inclusions and reduces toughness. This study explored various deoxidizers to control oxides in laser powder bed fusion-processed (L-PBF…
View article: Highly heterozygous <i>Citrus changshan-huyou</i> Y. B. Chang originated from ancient hybridization between mandarin and pummelo and displayed distinct tissue-specific allelic imbalance
Highly heterozygous <i>Citrus changshan-huyou</i> Y. B. Chang originated from ancient hybridization between mandarin and pummelo and displayed distinct tissue-specific allelic imbalance Open
The genus Citrus is characterized by a reticulate evolutionary history with frequent hybridization, making it an intriguing subject for genome evolution investigation. Citrus changshan Y. B. Chang (Huyou) is a unique landrace first discove…
View article: A Snapshot of Microbial Succession and Volatile Component Dynamics of Marselan Wine in Xinjiang During Spontaneous Fermentation
A Snapshot of Microbial Succession and Volatile Component Dynamics of Marselan Wine in Xinjiang During Spontaneous Fermentation Open
Marselan wine is characterized by distinctive flavors of blackcurrant, cranberry, and spice, which are significantly influenced by environmental factors such as region and climate. In this study, we analyzed the dynamic changes in the micr…
View article: Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells
Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells Open
Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin‐related force remodeling and play an important role in nuclear configuration and force‐sensing mechanotransduction of stem cells. However, further explorati…
View article: Regulation of the cathode inner Helmholtz plane in dilute ether electrolytes using an electric-field-responsive solvent for high-voltage lithium metal batteries
Regulation of the cathode inner Helmholtz plane in dilute ether electrolytes using an electric-field-responsive solvent for high-voltage lithium metal batteries Open
Herein, we demonstrate that the battery intrinsic electric field drives the specific adsorption of a weakly solvated co-solvent, DTS, to replace conventional DME in the IHP, enabling the desirable CEI chemistry on the 4.6 V LiCoO 2 cathode.
View article: Development and external validation of an interpretable machine learning model for the prediction of intubation in the intensive care unit
Development and external validation of an interpretable machine learning model for the prediction of intubation in the intensive care unit Open
Given the limited capacity to accurately determine the necessity for intubation in intensive care unit settings, this study aimed to develop and externally validate an interpretable machine learning model capable of predicting the need for…
View article: Comparative efficacy and safety of tenofovir amibufenamide vs tenofovir alafenamide in the initial 48-week treatment of high viral load chronic hepatitis B: A single-centre retrospective study
Comparative efficacy and safety of tenofovir amibufenamide vs tenofovir alafenamide in the initial 48-week treatment of high viral load chronic hepatitis B: A single-centre retrospective study Open
Background/aim Tenofovir amibufenamide (TMF) employs innovative ProTide technology and a methylation strategy to enhance the lipid solubility and plasma stability of the amide bond, providing advantages over tenofovir alafenamide (TAF). De…
View article: Development and Validation of an Interpretable Machine Learning Model for the Prediction of Intubation in the Intensive Care Unit
Development and Validation of an Interpretable Machine Learning Model for the Prediction of Intubation in the Intensive Care Unit Open
Background Since there is a limited ability to identify the need for intubation in the ICU, the objective of this study was to develop and validate an interpretable machine learning (ML) model to predict the need for intubation in ICU pati…
View article: The Effect of Agriculture Insurance on Agricultural Carbon Emissions in China: The Mediation Role of Low-Carbon Technology Innovation
The Effect of Agriculture Insurance on Agricultural Carbon Emissions in China: The Mediation Role of Low-Carbon Technology Innovation Open
Global greenhouse gas emissions are increasing, with carbon dioxide being the most prominent. It is urgent to address and resolve the carbon emissions problem. This study investigates the mediating mechanism of agricultural insurance and l…