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View article: YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix
YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix Open
Background Tumor-infiltrating regulatory T cells (TI-Tregs) are well-adapted to thrive in the challenging tumor microenvironment (TME) by undergoing metabolic reprogramming, notably shifting from glycolysis to mitochondrial oxidative phosp…
View article: circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR
circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR Open
View article: MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2
MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2 Open
Background Tumor necrosis factor receptor type 2 (TNFR2) is primarily expressed by CD4 + FoxP3 + regulatory T cells (Tregs), especially those present in tumor microenvironment. There is compelling evidence that TNFR2 plays a crucial role i…
View article: HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer
HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer Open
View article: HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis
HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis Open
Aberrant expression of histone deacetylase 6 (HDAC6) is greatly involved in neoplasm metastasis, which is a leading cause of colon cancer related death. Thus, deep understanding of the regulatory mechanisms of HDAC6 in the metastasis of co…
View article: HDAC6-Dependent Deacetylation of TAK1 Enhances sIL-6R Release to Promote Macrophage M2 Polarization in Colon Cancer
HDAC6-Dependent Deacetylation of TAK1 Enhances sIL-6R Release to Promote Macrophage M2 Polarization in Colon Cancer Open
Histone deacetylase 6 (HDAC6), a member of the HDAC family, has been identified as a potential therapeutic target for tumor therapy, but the function and underlying mechanisms of HDAC6 in colon cancer are incompletely characterized. Our st…
View article: The effects of <scp>TNF</scp>‐α/<scp>TNFR2</scp> in regulatory T cells on the microenvironment and progression of gastric cancer
The effects of <span>TNF</span>‐α/<span>TNFR2</span> in regulatory T cells on the microenvironment and progression of gastric cancer Open
TNFR2 + regulatory T cells preferentially accumulate in the tumor microenvironment, express high levels of immunosuppressive molecules and possess strong suppressive activity. Our study aimed to explore the characteristics and role of TNFR…
View article: circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer
circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer Open
Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs (ncRNAs) with a covalently closed loop structure. Accumulating evidence shows that circRNAs play vital roles in the growth, metastasis, treatment and prognosis of vari…
View article: “At last in” the physiological roles of the tubular ER network
“At last in” the physiological roles of the tubular ER network Open
In eukaryotic cells, the endoplasmic reticulum (ER) forms a continuous network of tubules and sheets. ER membranes are inter-connected by a class of dynamin-like GTPases termed atlastins (ATLs). Deletion or mutation of ATLs results in long…
View article: STIM1 interacts with termini of Orai channels in a sequential manner
STIM1 interacts with termini of Orai channels in a sequential manner Open
Store-operated Ca2+ entry (SOCE) is critical for numerous Ca2+-related processes. The activation of SOCE requires engagement between stromal interaction molecule 1 (STIM1) molecules on the endoplasmic reticulum and Ca2+ release-activated c…
View article: Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum
Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum Open
Significance In the early secretory pathway, newly synthesized proteins undergo folding and modifications and then leave the ER through COPII-coated vesicles. How these processes are coordinated and maintained are important but mostly uncl…
View article: Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites
Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites Open