Ling Li
YOU?
Author Swipe
View article: RamR T116I mutation confers tigecycline resistance in ST23 hypervirulent Klebsiella pneumoniae
RamR T116I mutation confers tigecycline resistance in ST23 hypervirulent Klebsiella pneumoniae Open
View article: Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study
Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study Open
These findings suggest that EAT volume is an independent indicator of CAD risk in men, particularly in non-obese individuals. The sex-specific differences emphasize the importance of personalized approaches to CAD risk assessment in the So…
View article: Machine learning-based prediction of invasiveness in lung adenocarcinoma presenting as ground-glass nodules using radiomics and clinical CT features
Machine learning-based prediction of invasiveness in lung adenocarcinoma presenting as ground-glass nodules using radiomics and clinical CT features Open
Background Lung adenocarcinoma(LA), the predominant histological subtype of lung cancer, frequently manifests as ground-glass nodules (GGNs) on computed tomography. Preoperative discrimination of invasiveness—critical for guiding surgical …
View article: The mediating role of dietary habits in the causal relationships between frailty, depression, and gastroesophageal reflux disease
The mediating role of dietary habits in the causal relationships between frailty, depression, and gastroesophageal reflux disease Open
Frailty, depression, and gastroesophageal reflux disease (GERD) are prevalent and interrelated conditions, particularly among older adults. Although dietary factors are implicated in these conditions, their causal relationships remain unce…
View article: Exploring the pharmacological action mechanism of chamomile essential oil on the treatment of breast cancer based on network pharmacology
Exploring the pharmacological action mechanism of chamomile essential oil on the treatment of breast cancer based on network pharmacology Open
Our research suggest that CEO inhibit proliferation of breast cancer cell lines through modulating those multi-pathways and multi-targets. The present study not only indicate the therapeutic potential of CEO for breast cancer, but also pro…
View article: Body roundness index and its role in predicting COPD risk: insights from the English Longitudinal Study of Aging and the health and retirement study
Body roundness index and its role in predicting COPD risk: insights from the English Longitudinal Study of Aging and the health and retirement study Open
Background Chronic obstructive pulmonary disease (COPD) is one of the most common chronic respiratory diseases worldwide. This study aims to investigate the relationship between the Body Roundness Index (BRI) and COPD in individuals aged 4…
View article: B-205 Mixed Batching of AVENIO Tumor Tissue CGP Samples with Various non-CGP Sample Libraries for Enhanced Sequencing Flexibility
B-205 Mixed Batching of AVENIO Tumor Tissue CGP Samples with Various non-CGP Sample Libraries for Enhanced Sequencing Flexibility Open
Background The AVENIO Tumor Tissue CGP Automated Assay (For Research Use Only (RUO). Not for use in diagnostic procedures.) is a fully automated NGS-based product that utilizes the FoundationOne® Analysis Platform to offer comprehensive ge…
View article: Complement component C6 deficiency exacerbates colorectal tumorigenesis by abolishing membrane attack complex formation and potentiating M2-like tumor-associated macrophage responses
Complement component C6 deficiency exacerbates colorectal tumorigenesis by abolishing membrane attack complex formation and potentiating M2-like tumor-associated macrophage responses Open
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, necessitating a deeper understanding of its underlying molecular mechanisms. The complement system, a prominent arsenal of innate immunity, has emerged as a …
View article: Survey of ICU nurses’ cognition, attitude, and practice on acute skin failure
Survey of ICU nurses’ cognition, attitude, and practice on acute skin failure Open
This study aims to investigate the cognition, attitude, and practice of acute skin failure (ASF) among nurses in the intensive care unit (ICU) and analyze its influencing factors. In July 2023, an ASF Cognition Status Questionnaire was use…
View article: Molecular mechanism of resveratrol in suppressing lung adenocarcinoma based on network pharmacology and molecular docking
Molecular mechanism of resveratrol in suppressing lung adenocarcinoma based on network pharmacology and molecular docking Open
Resveratrol is a natural polyphenol known for its antioxidant and anti-inflammatory effects, but its role in lung adenocarcinoma (LUAD) remains unclear. Our study integrated network pharmacology, molecular docking, and bioinformatics to in…
View article: Pulmonary and Immune Dysfunction in Pediatric Long COVID: A Case Study Evaluating the Utility of ChatGPT-4 for Analyzing Scientific Articles
Pulmonary and Immune Dysfunction in Pediatric Long COVID: A Case Study Evaluating the Utility of ChatGPT-4 for Analyzing Scientific Articles Open
Coronavirus disease 2019 (COVID-19) in adults is well characterized and associated with multisystem dysfunction. A subset of patients develop post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID), marked by persistent and fluct…
View article: Correlation between the body roundness index and chronic obstructive pulmonary disease: a cross-sectional analysis
Correlation between the body roundness index and chronic obstructive pulmonary disease: a cross-sectional analysis Open
Background Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, with abdominal fat, particularly visceral fat, closely associated with its onset and progression. While the lipid accumulation product (LAP) has…
View article: The relationship between lung function and headache risk in middle-aged and older adults: a cross-sectional and longitudinal study
The relationship between lung function and headache risk in middle-aged and older adults: a cross-sectional and longitudinal study Open
View article: Review of Toxoplasmosis: What We Still Need to Do
Review of Toxoplasmosis: What We Still Need to Do Open
Toxoplasma gondii is responsible for the disease toxoplasmosis and has the broadest host range among apicomplexan parasites, as it infects virtually all warm-blooded vertebrates. Toxoplasmosis is a zoonotic and emerging public health conce…
View article: A nomogram-based prediction model for motoric cognitive risk syndrome in patients with coronary artery disease: a cross-sectional study
A nomogram-based prediction model for motoric cognitive risk syndrome in patients with coronary artery disease: a cross-sectional study Open
View article: RNA target-independent non-canonical activation (RINCA) of Cas13 trans-nuclease activity
RNA target-independent non-canonical activation (RINCA) of Cas13 trans-nuclease activity Open
A thorough understanding of unintended Cas13 activity is critical for ensuring the safe in vivo application of CRISPR-Cas13. In this study, we uncover the RNA target-independent, non-canonical activation (RINCA) of Cas13 by crRNA alone and…
View article: Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults
Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults Open
Backgrounds The triglyceride-glucose index combined with waist circumference (TyG-WC) has good predictive performance for cardiovascular disease, but the relationship of TyG-WC with H-type hypertension (HTH) is still unclear. Objects To ex…
View article: Transcriptional Regulation Networks of Cold Hardiness in Galeruca daurica (Coleoptera: Chrysomelidae) and HSF1-Mediated HSP26 and HSP68 Expression Validation
Transcriptional Regulation Networks of Cold Hardiness in Galeruca daurica (Coleoptera: Chrysomelidae) and HSF1-Mediated HSP26 and HSP68 Expression Validation Open
Background Galeruca daurica (Joannis), a notorious pest in Northern China, seriously threatens Inner Mongolia grassland ecosystems and economy, due to its strong cold hardiness and huge outbreak in a short time. Despite previous studies em…
View article: Targeting prostate cancer with site-specific antibody-drug conjugates enabled by tandemly fused ADP-ribosyl cyclases
Targeting prostate cancer with site-specific antibody-drug conjugates enabled by tandemly fused ADP-ribosyl cyclases Open
Antibody-drug conjugates (ADCs) bring superior efficacy and safety profiles to the clinic by harnessing the power of biologics and chemotherapy. Despite numerous ADCs at different preclinical and clinical stages, homogeneous ADC with incre…
View article: Molecular Characterization of Organic Aerosol in Summer Suburban Shanghai Under High Humidity
Molecular Characterization of Organic Aerosol in Summer Suburban Shanghai Under High Humidity Open
In this study, the chemical compositions of PM2.5 (particulate matter < 2.5 μm) and the molecular compositions of methanol-soluble organic carbon (MSOC) in suburban Shanghai during summer were measured to investigate the molecular characte…
View article: Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway
Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway Open
Molecular mechanisms underlying disruptions in brain glucose uptake and metabolism, linked with cognitive decline in Alzheimer’s disease (AD) patients, are only partially understood. This study investigated how soluble amyloid beta (sAβ) p…
View article: Potential roles of antibodies with different classes in IgG4‐related diseases
Potential roles of antibodies with different classes in IgG4‐related diseases Open
Immunoglobulin G4‐related disease (IgG4‐RD), first identified two decades ago, is an immune‐mediated pro‐inflammatory and profibrotic disease entity affecting multiple organs. The main histopathological features are a dense lymphoplasmacyt…
View article: Genetic modification of Water spinach (<i>Ipomoea aquatica</i>), a genoprotective perennial leafy green
Genetic modification of Water spinach (<i>Ipomoea aquatica</i>), a genoprotective perennial leafy green Open
Improvement of leafy greens, especially perennials with year‐round harvesting, is binding to the food security drive. “Food for All” by WHO demands the improvement of regional crops due to the agroclimatic specificity to ensure regional fo…
View article: Optimization of handmade cloning enhances pregnancy rates and live calf production in cattle
Optimization of handmade cloning enhances pregnancy rates and live calf production in cattle Open
View article: Association between serum cystatin C and chronic lung disease in middle-aged and elderly Chinese: a CHARLS cross-sectional study
Association between serum cystatin C and chronic lung disease in middle-aged and elderly Chinese: a CHARLS cross-sectional study Open
The dose-response relationship between cystatin C (CysC) levels and chronic lung disease (CLD) development remains unclear and warrants further investigation. A more in-depth study of the relationship between serum CysC levels and CLD prev…
View article: Assessing and Understanding Creativity in Large Language Models
Assessing and Understanding Creativity in Large Language Models Open
In the field of natural language processing, the rapid development of large language model (LLM) has attracted increasing attention. LLMs have shown a high level of creativity in various tasks, but the methods for assessing such creativity…
View article: Long noncoding RNA UCA1 knockdown inhibits cisplatin-resistant cervical cancer tumorigenesis via the miR-195-5p/IKBKB axis
Long noncoding RNA UCA1 knockdown inhibits cisplatin-resistant cervical cancer tumorigenesis via the miR-195-5p/IKBKB axis Open
Cisplatin resistance is a major cause of poor prognosis in patients with cervical cancer. Dysregulation of long noncoding RNAs (lncRNAs) plays a key role in chemoresistance. Our results reveal that the lncRNA UCA1 is upregulated in cisplat…
View article: The predictive values of sarcopenia screening tools in preoperative elderly patients with colorectal cancer: applying the diagnostic criteria of EWGSOP2 and AWGS2019
The predictive values of sarcopenia screening tools in preoperative elderly patients with colorectal cancer: applying the diagnostic criteria of EWGSOP2 and AWGS2019 Open
View article: Digital gait biomarkers in Parkinson’s disease: susceptibility/risk, progression, response to exercise, and prognosis
Digital gait biomarkers in Parkinson’s disease: susceptibility/risk, progression, response to exercise, and prognosis Open
This narrative review examines the utility of gait digital biomarkers in Parkinson's disease (PD) research and clinical trials across four contexts: disease susceptibility/risk, disease progression, response to exercise, and fall predictio…
View article: IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression
IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression Open
An increase in conjunctival IL-23 expression contributes to the induction of the DED inflammatory response through interactions with its cognate receptor on γδT cells and the promotion of their proliferation. The findings of this study sug…