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View article: A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane
A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane Open
The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphatidylethanolamine mostly on the inner leaflet and phosphatidylcholine mostly on the outer leaf…
View article: Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila
Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila Open
Animals can acutely sense a puncture or cut in their skin through nociceptors. However, the molecular identity of such "wound signals" and their receptors on nociceptors remains unknown. In Drosophila larvae, class IV dendritic arborizatio…
View article: Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia activity
Atypical developmental remodeling of dopamine neurons involves AKT-GSK3β signaling and glia activity Open
Summary Neuronal remodeling is essential for sculpting neural circuits, and its disruption has been implicated in neurodevelopmental and neuropsychiatric disorders. Yet the molecular and cellular diversity of remodeling across neuron types…
View article: A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane
A cell-based scrambling assay reveals phospholipid headgroup preference of TMEM16F on the plasma membrane Open
The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphatidylethanolamine mostly on the inner leaflet, and phosphatidylcholine mostly on the outer lea…
View article: Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families Open
Calcium (Ca2+)-activated ion channels and lipid scramblases in the transmembrane protein 16 (TMEM16) family are structurally related to mechanosensitive ion channels in the TMEM63 and transmembrane channel-like (TMC) families. M…
View article: Voltage sensors
Voltage sensors Open
Widely distributed in all kingdoms of life, voltage sensors in the membrane serve important functions via their movements driven by changes in voltage across the membrane (membrane potential). A voltage sensor domain contains 4 transmembra…
View article: SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling Open
View article: TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons
TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons Open
TMEM16F is a calcium-activated phospholipid scramblase and nonselective ion channel, which allows the movement of lipids bidirectionally across the plasma membrane. While the functions of TMEM16F have been extensively characterized in mult…
View article: Nonlinear compliance of NompC gating spring and its implication in mechanotransduction
Nonlinear compliance of NompC gating spring and its implication in mechanotransduction Open
Cytoskeleton-tethered mechanosensitive channels (MSCs) utilize compliant proteins or protein domains called gating springs to convert mechanical stimuli into electric signals, enabling sound and touch sensation and proprioception. The mech…
View article: Structure, function and pharmacology of human itch GPCRs
Structure, function and pharmacology of human itch GPCRs Open
The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related ma…
View article: Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels Open
Cells sense physical forces and convert them into electrical or chemical signals, a process known as mechanotransduction. Whereas extensive studies focus on mechanotransduction at the plasma membrane, little is known about whether and how …
View article: WTR: An Anterograde Tracing Toolkit for Neural Circuits Mapping
WTR: An Anterograde Tracing Toolkit for Neural Circuits Mapping Open
View article: Correction to: Rare variants in <i>ANO1</i>, encoding a calcium-activated chloride channel, predispose to moyamoya disease
Correction to: Rare variants in <i>ANO1</i>, encoding a calcium-activated chloride channel, predispose to moyamoya disease Open
Rare variants in ANO1, encoding a calcium-activated chloride
View article: Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase Open
The dual functions of TMEM16F as Ca 2+ -activated ion channel and lipid scramblase raise intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA-approved drug niclosamide to inhibit TMEM16F-dependent syncy…
View article: Rare variants in <i>ANO1</i>, encoding a calcium-activated chloride channel, predispose to moyamoya disease
Rare variants in <i>ANO1</i>, encoding a calcium-activated chloride channel, predispose to moyamoya disease Open
Moyamoya disease, a cerebrovascular disease leading to strokes in children and young adults, is characterized by progressive occlusion of the distal internal carotid arteries and the formation of collateral vessels. Altered genes play a pr…
View article: Inwardly rectifying potassium channels (K<sub>IR</sub>) in GtoPdb v.2023.1
Inwardly rectifying potassium channels (K<sub>IR</sub>) in GtoPdb v.2023.1 Open
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K ch…
View article: Voltage-gated potassium channels (K<sub>v</sub>) in GtoPdb v.2023.1
Voltage-gated potassium channels (K<sub>v</sub>) in GtoPdb v.2023.1 Open
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels …
View article: SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling Open
To facilitate our understanding of the often rapid and nuanced dynamics of extracellularly exposed proteomes during signaling events, it is important to devise robust workflows affording fast time resolution without biases and confounding …
View article: The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling
The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling Open
Membrane trafficking is essential for sculpting neuronal morphology. The GARP and EARP complexes are conserved tethers that regulate vesicle trafficking in the secretory and endolysosomal pathways, respectively. Both complexes contain the …
View article: A photo-switchable assay system for dendrite degeneration and repair in <i>Drosophila melanogaster</i>
A photo-switchable assay system for dendrite degeneration and repair in <i>Drosophila melanogaster</i> Open
Neurodegeneration arising from aging, injury, or diseases has devastating health consequences. Whereas neuronal survival and axon degeneration have been studied extensively, much less is known about how neurodegeneration affects dendrites,…
View article: K <sub>v</sub> 1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis
K <sub>v</sub> 1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis Open
Significance Despite decades of research on adult neurogenesis, little is known about the role of bioelectric signaling in this process. In this study, we describe how a voltage-gated potassium channel, K v 1.1, supports adult neurogenesis…
View article: Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes
Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes Open
View article: Author response: Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development
Author response: Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Sensory n…
View article: Identification of a conserved drug binding pocket in TMEM16 proteins
Identification of a conserved drug binding pocket in TMEM16 proteins Open
The TMEM16 family of calcium-activated membrane proteins includes ten mammalian paralogs (TMEM16A-K) playing distinct physiological roles with some implicated in cancer and airway diseases. Their modulators with therapeutic potential inclu…
View article: Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development
Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development Open
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral tra…
View article: Steroid hormone signaling activates thermal nociception during <i>Drosophila</i> peripheral nervous system development
Steroid hormone signaling activates thermal nociception during <i>Drosophila</i> peripheral nervous system development Open
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral tra…
View article: Structure, function and pharmacology of human itch GPCRs
Structure, function and pharmacology of human itch GPCRs Open
View article: Loss of the GARP but not EARP protein complex drives Golgi sterol overload during dendrite remodeling
Loss of the GARP but not EARP protein complex drives Golgi sterol overload during dendrite remodeling Open
Membrane trafficking is essential for sculpting neuronal morphology. The GARP and EARP complexes are conserved tethers that regulate vesicle trafficking in the secretory and endolysosomal pathways, respectively. Both complexes contain the …
View article: Inwardly rectifying potassium channels (K<sub>IR</sub>) in GtoPdb v.2021.3
Inwardly rectifying potassium channels (K<sub>IR</sub>) in GtoPdb v.2021.3 Open
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K ch…
View article: Voltage-gated potassium channels (K<sub>v</sub>) in GtoPdb v.2021.3
Voltage-gated potassium channels (K<sub>v</sub>) in GtoPdb v.2021.3 Open
The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels …