Limei Cui
YOU?
Author Swipe
View article: Research progress on exosomes in the otology field: a systematic review
Research progress on exosomes in the otology field: a systematic review Open
Exosomes, characterized by their distinctive structural and functional properties, are increasingly recognized as an important focus of research in otology, offering considerable promise for both diagnostic and therapeutic purposes. This r…
View article: Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology
Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology Open
Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods Th…
View article: Untargeted Metabolomic Analysis of Exhaled Breath Condensate Identifies Disease‐Specific Signatures in Adults With Asthma
Untargeted Metabolomic Analysis of Exhaled Breath Condensate Identifies Disease‐Specific Signatures in Adults With Asthma Open
Purpose An objective test for the auxiliary diagnosis of asthma is still lacking. The aim of this study was to discriminate asthma signatures via an untargeted metabolomic analysis of exhaled breath condensate. Materials and Methods This s…
View article: Transforming Growth Factor‐β‐Activated Protein 1 (<scp>TAK1</scp>) Regulates Necroptosis in Age‐Related Hearing Loss
Transforming Growth Factor‐β‐Activated Protein 1 (<span>TAK1</span>) Regulates Necroptosis in Age‐Related Hearing Loss Open
Inflammation plays an important role in age‐related hearing loss (ARHL). Transforming growth factor‐β‐activated protein 1 (TAK1), a key factor upstream of inflammatory pathways, mediates various cell death pathways, potentially influencing…
View article: Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases
Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases Open
Under the concept of “one airway, one disease”, upper and lower airway inflammatory diseases share similar pathogenic mechanisms and are collectively referred to as airway inflammatory diseases. With industrial development and environmenta…
View article: Inhibition of lysine-specific histone demethylase 1A suppresses adenomyosis through reduction in ectopic endometrial stromal cell proliferation, migration, and invasion
Inhibition of lysine-specific histone demethylase 1A suppresses adenomyosis through reduction in ectopic endometrial stromal cell proliferation, migration, and invasion Open
Objective: Deep endometriosis is now referred to as adenomyosis externa, whereas adenomyosis is once known as endometriosis interna. Lysine-specific histone demethylase 1A (KDM1A, commonly LSD1) is a lysine demethylase that targets histone…
View article: Exploring the Pharmacological Mechanisms of Ginkgo biloba Extract in the Treatment of Sensorineural Hearing Loss
Exploring the Pharmacological Mechanisms of Ginkgo biloba Extract in the Treatment of Sensorineural Hearing Loss Open
Backgrounds: Anincreasing people are suffering from sensorineural hearing loss (SNHL) and facing great psychological and physical stress. Although the extract of extract of Ginkgo biloba (EGb) has been widely used to treat SNHL for many ye…
View article: Potential molecular mechanisms of Erlongjiaonang action in idiopathic sudden hearing loss: A network pharmacology and molecular docking analyses
Potential molecular mechanisms of Erlongjiaonang action in idiopathic sudden hearing loss: A network pharmacology and molecular docking analyses Open
Background Idiopathic sudden hearing loss (ISHL) is characterized by sudden unexplainable and unilateral hearing loss as a clinically emergent symptom. The use of the herb Erlongjiaonang (ELJN) in traditional Chinese medicine is known to e…
View article: TMEM16A Inhibits Autophagy and Promotes the Invasion of Hypopharyngeal Squamous Cell Carcinoma Through mTOR Pathway
TMEM16A Inhibits Autophagy and Promotes the Invasion of Hypopharyngeal Squamous Cell Carcinoma Through mTOR Pathway Open
Background Previous investigations indicated that transmembrane protein 16A (TMEM16A) mediates the pathogenesis and malignant of many tumors through regulating multiple pathways. However, whether TMEM16A could regulate autophagy via mammal…
View article: A newly identified mutation (c.2029 C > T) in SLC26A4 gene is associated with enlarged vestibular aqueducts in a Chinese family
A newly identified mutation (c.2029 C > T) in SLC26A4 gene is associated with enlarged vestibular aqueducts in a Chinese family Open
Background The enlarged vestibular aqueduct (EVA), associated with mutations in the SLC26A4 gene, characterized by non-syndromic hearing loss, is an autosomal recessive disorder. Here, we intended to investigate genetic causes of hearing l…
View article: Tissue-specific expression atlas of murine mitochondrial tRNAs
Tissue-specific expression atlas of murine mitochondrial tRNAs Open
Mammalian mitochondrial tRNA (mt-tRNA) plays a central role in the synthesis of the 13 subunits of the oxidative phosphorylation complex system (OXPHOS). However, many aspects of the context-dependent expression of mt-tRNAs in mammals rema…
View article: DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma Open
This study for the first time demonstrated the clinical value and the role of DNMT1 and MGMT in the biological function of hypopharyngeal squamous carcinoma. This work suggested that DNMT1 might serve as a potential therapeutic target for …
View article: Asthma does not influence the severity of COVID-19: a meta-analysis
Asthma does not influence the severity of COVID-19: a meta-analysis Open
Taken together, our data suggested that asthma is not a significant risk factor for the development of severe COVID-19.
View article: Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss Open
The pathophysiology underlying spiral ganglion cell defect-induced deafness remains elusive. Using the whole exome sequencing approach, in combination with functional assays and a mouse disease model, we identified the potentially novel de…
View article: Role of TGF‑&beta;1‑mediated epithelial‑mesenchymal transition in the pathogenesis of tympanosclerosis
Role of TGF‑β1‑mediated epithelial‑mesenchymal transition in the pathogenesis of tympanosclerosis Open
The present study aimed to explore the role of TGF-β1-mediated epithelial-mesenchymal transition (EMT) in the pathogenesis of tympanosclerosis. Sprague Dawley rats were injected with inactivated Streptococcus pneumoniae suspension to estab…
View article: Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNAHis mutation
Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNAHis mutation Open
The deafness-associated m.12201T>C mutation affects the A5-U68 base-pairing within the acceptor stem of mitochondrial tRNAHis. The primary defect in this mutation is an alteration in tRNAHis aminoacylation. Here, we further investigate the…
View article: Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation
Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation Open
Nuclear modifier genes have been proposed to modify the phenotypic expression of mitochondrial DNA mutations. Using a targeted exome-sequencing approach, here we found that the p.191Gly>Val mutation in mitochondrial tyrosyl-tRNA synthetase…
View article: Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript
Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript Open
Mitochondrial tRNA processing defects were associated with human diseases but their pathophysiology remains elusively. The hypertension-associated m.4401A>G mutation resided at a spacer between mitochondrial tRNAMet and tRNAGln genes. An i…
View article: Biochemical evidence for a mitochondrial genetic modifier in the phenotypic manifestation of Leber’s hereditary optic neuropathy-associated mitochondrial DNA mutation
Biochemical evidence for a mitochondrial genetic modifier in the phenotypic manifestation of Leber’s hereditary optic neuropathy-associated mitochondrial DNA mutation Open
Leber's hereditary optic neuropathy (LHON) is the most common mitochondrial disease. Mitochondrial modifiers are proposed to modify the phenotypic expression of primary LHON-associated mitochondrial DNA (mtDNA) mutations. In this study, we…