Lei Han
YOU?
Author Swipe
View article: Targeting Ferroptosis in Sensorineural Hearing Loss: A Mechanistic Review of Therapeutic Opportunities
Targeting Ferroptosis in Sensorineural Hearing Loss: A Mechanistic Review of Therapeutic Opportunities Open
Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a critical pathogenic mechanism and a highly promising therapeutic target in sensorineural hearing loss (SNHL). The irreversible loss of auditory hair cells, the h…
View article: CCL2/CCR2 signaling pathway in tumorigenesis and metastasis (Review)
CCL2/CCR2 signaling pathway in tumorigenesis and metastasis (Review) Open
C-C motif chemokine ligand 2 (CCL2) is associated with tumorigenesis and cancer progression. C-C motif chemokine receptor 2 (CCR2) is the main receptor of CCL2. The present review aimed to summarize the role of the CCL2/CCR2 signaling axis…
View article: Minimal Semantic Sufficiency Meets Unsupervised Domain Generalization
Minimal Semantic Sufficiency Meets Unsupervised Domain Generalization Open
The generalization ability of deep learning has been extensively studied in supervised settings, yet it remains less explored in unsupervised scenarios. Recently, the Unsupervised Domain Generalization (UDG) task has been proposed to enhan…
View article: The role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth
The role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth Open
Our study indicates that elevated expression of YTHDF1 is a predictor of poor prognosis in patients with LUAD and may serve as a potential diagnostic biomarker and therapeutic target for this disease. In addition, we identified LY-411575 a…
View article: SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks
SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks Open
Single‐cell cis‐regulatory relationships (CRRs) are essential for deciphering transcriptional regulation and understanding the pathogenic mechanisms of disease‐associated non‐coding variants. Existing computational methods struggle to accu…
View article: Ameloblastoma in a preschool child
Ameloblastoma in a preschool child Open
View article: BrainBeacon: A Cross-Species Foundation Model for Single-cell Resolved Brain Spatial Transcriptomics
BrainBeacon: A Cross-Species Foundation Model for Single-cell Resolved Brain Spatial Transcriptomics Open
The brain’s functional complexity emerges from spatiotemporal heterogeneity in molecular, cellular, and circuit organization, shaped by evolution, aging, and disease. Single-cell spatial transcriptomics provides a transformative framework …
View article: Triglyceride–Glucose-Based Anthropometric Indices for Predicting Incident Cardiovascular Disease: Relative Fat Mass (RFM) as a Robust Indicator
Triglyceride–Glucose-Based Anthropometric Indices for Predicting Incident Cardiovascular Disease: Relative Fat Mass (RFM) as a Robust Indicator Open
Background/Objectives: The triglyceride–glucose (TyG) index is a recognized marker for cardiovascular disease (CVD) risk linked to insulin resistance. Combining TyG with anthropometric indicators (AIs) may improve risk prediction, but the …
View article: Drivers of Layered Circulations in the South China Sea: Volume Flux or Vorticity Flux?
Drivers of Layered Circulations in the South China Sea: Volume Flux or Vorticity Flux? Open
The South China Sea (SCS) features a unique layered circulation structure known as the cyclonic-anticyclonic-cyclonic (CAC) pattern, whose driving mechanisms remain a subject of debate. This study employs idealized numerical simulations us…
View article: A novel mutation in ZP3 causes human ovulatory dysfunction and oocyte maturation arrest
A novel mutation in ZP3 causes human ovulatory dysfunction and oocyte maturation arrest Open
Not applicable.
View article: Validation of S100A16 as an asthma biomarker and its role in IL-13-induced bronchial epithelial cell injury
Validation of S100A16 as an asthma biomarker and its role in IL-13-induced bronchial epithelial cell injury Open
This study identified a new biomarker, S100A16, for the diagnosis of asthma. S100A16 may serve as a new potential target for asthma treatment, and may be an important regulator of ferroptosis.
View article: Aneumo: A Large-Scale Multimodal Aneurysm Dataset with Computational Fluid Dynamics Simulations and Deep Learning Benchmarks
Aneumo: A Large-Scale Multimodal Aneurysm Dataset with Computational Fluid Dynamics Simulations and Deep Learning Benchmarks Open
Intracranial aneurysms (IAs) are serious cerebrovascular lesions found in approximately 5\% of the general population. Their rupture may lead to high mortality. Current methods for assessing IA risk focus on morphological and patient-speci…
View article: ChromFound: Towards A Universal Foundation Model for Single-Cell Chromatin Accessibility Data
ChromFound: Towards A Universal Foundation Model for Single-Cell Chromatin Accessibility Data Open
The advent of single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) offers an innovative perspective for deciphering regulatory mechanisms by assembling a vast repository of single-cell chromatin accessibilit…
View article: Prediction of Ki-67 expression in hepatocellular carcinoma with machine learning models based on intratumoral and peritumoral radiomic features
Prediction of Ki-67 expression in hepatocellular carcinoma with machine learning models based on intratumoral and peritumoral radiomic features Open
BACKGROUND Hepatocellular carcinoma (HCC) is one of the most common malignant tumours of the digestive system worldwide. The expression of Ki-67 is crucial for the diagnosis, treatment, and prognostic evaluation of HCC. AIM To construct a …
View article: A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome
A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome Open
View article: Insights From Nonsense‐Mediated <scp>mRNA</scp> Decay for Prognosis in Homologous Recombination‐Deficient Ovarian Cancer
Insights From Nonsense‐Mediated <span>mRNA</span> Decay for Prognosis in Homologous Recombination‐Deficient Ovarian Cancer Open
Not all ovarian cancer patients with homologous recombination deficiency, especially those with germline BRCA mutations, can benefit from platinum‐based and targeted therapy. Our study aimed to determine the value of nonsense‐mediated mRNA…
View article: Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer
Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer Open
View article: Restoration of Periodontitis-Induced Bone Defects with Multifunctional Barrier Membranes by Alleviating Oxidative Stress and Remodelling Macrophage Metabolism
Restoration of Periodontitis-Induced Bone Defects with Multifunctional Barrier Membranes by Alleviating Oxidative Stress and Remodelling Macrophage Metabolism Open
View article: Disease burden analysis of coal worker pneumoconiosis patients in Jiangsu Province
Disease burden analysis of coal worker pneumoconiosis patients in Jiangsu Province Open
View article: VASH2 enhances KIF3C-mediated EGFR-endosomal recycling to promote aggression and chemoresistance of lung squamous cell carcinoma by increasing tubulin detyrosination
VASH2 enhances KIF3C-mediated EGFR-endosomal recycling to promote aggression and chemoresistance of lung squamous cell carcinoma by increasing tubulin detyrosination Open
Lung squamous cell carcinoma (LUSC) is associated with high mortality and has few therapeutic options. Chemotherapy remains the main treatment for LUSC patients, but multi-drug resistance has become the dominant challenge in the failure of…
View article: Integrated analysis and experiments uncover the function of disulfidptosis in predicting immunotherapy effectiveness and delineating immune landscapes in uterine corpus endometrial carcinoma
Integrated analysis and experiments uncover the function of disulfidptosis in predicting immunotherapy effectiveness and delineating immune landscapes in uterine corpus endometrial carcinoma Open
Introduction Recently, a novel type of metabolic-regulated cell demise titled disulfidptosis has been discovered. Studies have demonstrated its importance in immune responses against cancer and its impact on the proliferation of cancer cel…
View article: UBE2L3 promotes benzene-induced hematotoxicity via autophagy-dependent ferroptosis
UBE2L3 promotes benzene-induced hematotoxicity via autophagy-dependent ferroptosis Open
Benzene is a common environmental pollutant and significant health hazard. Low-dose benzene exposure is common in most industrial settings, and some workers exhibit hematotoxicity characterized by impaired hematopoietic function. Consequen…
View article: Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis
Promoter Methylation Changes in DNA Damage-Response Genes in Ovarian Cancer and Their Correlation with Prognosis Open
Background: Ovarian cancer has a poor prognosis, and DNA damage-response (DDR) genes are associated with both its occurrence and prognosis. However, previous studies have mostly focused on genetic mutations, with no clear conclusions on ep…
View article: Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China
Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China Open
View article: Predicting coal workers’ pneumoconiosis trends: Leveraging historical data with the GARCH model in a Chinese Miner Cohort
Predicting coal workers’ pneumoconiosis trends: Leveraging historical data with the GARCH model in a Chinese Miner Cohort Open
Coal workers’ pneumoconiosis (CWP) is one of the most common and severe occupational diseases worldwide. The main risk factor of CWP is exposure to respirable mine dust. Prediction theory was widely applied in the prediction of the epidemi…
View article: Research progress of Paris polyphylla in the treatment of digestive tract cancers
Research progress of Paris polyphylla in the treatment of digestive tract cancers Open
Cancer has become one of the most important causes of human death. In particular, the 5 year survival rate of patients with digestive tract cancer is low. Although chemotherapy drugs have a certain efficacy, they are highly toxic and prone…
View article: Comparison of the efficacy of different models in predicting the progression of Pulmonary Hypertension
Comparison of the efficacy of different models in predicting the progression of Pulmonary Hypertension Open
Objective To identify the risk factors associated with the progression of pulmonary hypertension (PH), develop two distinct risk prediction models, and provide valuable insights for clinical management. Methods This study employed a retros…
View article: Identification an novel classification and nomogram of programmed cell-death patterns for investigating the immune microenvironment and prognosis of postoperative ovarian cancer patients
Identification an novel classification and nomogram of programmed cell-death patterns for investigating the immune microenvironment and prognosis of postoperative ovarian cancer patients Open
Background: Ovarian cancer (OV) is a highly aggressive and often fatal disease that frequently goes undetected until it has already metastasized. The classic treatment for ovarian cancer involves surgery followed by chemotherapy. However, …
View article: Conducting quantitative mask fit tests: application details and affecting factors
Conducting quantitative mask fit tests: application details and affecting factors Open
Introduction Respirators chosen based on their assigned protection factor (APF) enable wearers to effectively reduce particulate matter concentrations to safe levels when used correctly. As a crucial factor in achieving the intended APF, t…
View article: Identification machine learning-based model of programmed cell-death patterns for investigating the immune microenvironment and prognosis of ovarian cancer patients after surgery and providing therapeutic strategies
Identification machine learning-based model of programmed cell-death patterns for investigating the immune microenvironment and prognosis of ovarian cancer patients after surgery and providing therapeutic strategies Open
Background Ovarian cancer (OV) is a highly aggressive and often fatal disease that frequently goes undetected until it has already metastasized. The classic treatment for ovarian cancer involves surgery followed by chemotherapy. However, d…