Limei Ju
YOU?
Author Swipe
View article: Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures Open
View article: Distinct response of adult neural stem cells to low versus high dose ionising radiation
Distinct response of adult neural stem cells to low versus high dose ionising radiation Open
Radiosusceptibility is the sensitivity of a biological organism to ionising radiation (IR)-induced carcinogenesis, an outcome of IR exposure relevant following low doses. The tissue response is strongly influenced by the DNA damage respons…
View article: Aberrant PARP1 Activity Couples DNA Breaks to Deregulated Presynaptic Calcium Signalling and Lethal Seizures
Aberrant PARP1 Activity Couples DNA Breaks to Deregulated Presynaptic Calcium Signalling and Lethal Seizures Open
Defects in DNA single-strand break repair result in cerebellar ataxia which in Xrcc1 Nes-Cre mice is promoted by hyperactivity of the DNA strand break sensor protein, Parp1. Here, we show that Parp1 hyperactivity extends beyond the cerebel…
View article: A coordinated DNA damage response promotes adult quiescent neural stem cell activation
A coordinated DNA damage response promotes adult quiescent neural stem cell activation Open
Stem and differentiated cells frequently differ in their response to DNA damage, which can determine tissue sensitivity. By exploiting insight into the spatial arrangement of subdomains within the adult neural subventricular zone (SVZ) in …
View article: XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia
XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia Open
View article: Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates
Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates Open
In mitotic cells, the cyclin-dependent kinase (CDK) subunit protein CKS1 regulates S phase entry by mediating degradation of the CDK inhibitor p27. Although mature neurons lack mitotic CDKs, we found that CKS1 was actively expressed in pos…
View article: Endogenous and X-ray-induced DNA double strand breaks sensitively activate apoptosis in adult neural stem cells
Endogenous and X-ray-induced DNA double strand breaks sensitively activate apoptosis in adult neural stem cells Open
The embryonic neural stem cell compartment is characterised by rapid proliferation from E11 to E16.5, high endogenous DNA double-strand break (DSB) formation and marked sensitivity to undergo apoptosis. Here, we ask whether DSBs arise in t…