Explanipedia

NSD2 mediates NF-κB and matrix metalloproteinases to drive hepatocellular carcinoma malignant progression Open

Meng Xiong, Qianshan Ding, Yingjie Wu, Muhammad Jamal, Xingruo Zeng , et al. · 2025

In summary, NSD2 acts as a tumorigenic factor in the progression of HCC by activating the NF-κB and MMPs signalling pathways.

Trueness Of Three Digital Methods For Obtaining Occlusal Relationships Open

Wenjie Ma, Liang Shao, Qian Ding, Xiaole Zhao, Zhixiao Wu · 2025

Aim or purpose: Integrating the model scanning (MS) and intraoral scanning (IOS) techniques, a new digital method, MS+IOS, was proposed to obtain full-arch occlusal relationships more accurately. Materials and methods: Three methods were u…

The role of fecal microbiota transplantation in the treatment of acute graft-versus-host disease Open

Zhi Guo, Mingxin He, Liang Shao, Yue Li, Xiaochen Xiang , et al. · 2024

Medicine

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most important methods for treating a wide range of hematologic malignancies and bone marrow failure diseases. However, graft-versus-host disease (GVHD), a major …

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis Open

Muhammad Jamal, Yufei Lei, Hengjing He, Xingruo Zeng, Hina Iqbal Bangash , et al. · 2023

Chemistry Biology

Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of the lymphoid progenitor cells, contributing to ∼ 20% of the total ALL cases, with a higher prevalence in adults than children. Despite t…

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis Open

Muhammad Jamal, Yufei Lei, Hengjing He, Xingruo Zeng, Zimeng Wei , et al. · 2023

Biology

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of the lymphoid progenitor cells contributing to ∼ 20% of the total ALL cases with higher prevalence in adults than the children. Despite the important r…

Extracellular Volume Fraction Based on Cardiac Magnetic Resonance T1 Mapping: An Effective Way to Evaluate Cardiac Injury Caused by Cardiac Amyloidosis in Patients with Multiple Myeloma Open

Liu Ming-hui, Liang Shao, Zhaoxia Yang, Qian Wang, Balu Wu , et al. · 2022

Medicine Chemistry

Multiple myeloma (MM) is a hematological malignancy of plasma cell origin. Cardiac amyloidosis (CA) is a common form of heart damage caused by MM and is associated with a poor prognosis. This study was a prospective cohort study and was ai…

Additional file 1 of FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner Open

Jiapeng Huang, Wei Sun, Zhihong Wang, Chengzhou Lv, Ting Zhang , et al. · 2022

Chemistry Biology Medicine

Additional file 1: Table S1. The sequence of si-RNAs. Table S2. The sequence of primers. Table S3. The Antibodies for western blot, IHC and RIP. Table S4. Correlation between FTO expression and clinicopathological features of PTC patients …

LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25 Open

Jingyuan Li, Muhammad Jamal, Tian Xie, Jiaxing Sun, Yufei Lei , et al. · 2021

Biology Medicine Physics

These findings indicate that LINC00853 restrains T-ALL cell invasion and infiltration by regulating CCR9/CCL25.

Recent Progress on Primary Central Nervous System Lymphoma—From Bench to Bedside Open

Liang Shao, Chengshi Xu, Huijing Wu, Muhammad Jamal, Shan Pan , et al. · 2021

Medicine Biology

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extra-nodal lymphoma. The high relapse rate of PCNSL remains a major challenge to the hematologists, even though patients exhibit high sensitivity to the methotrexate-bas…

Immune dysregulation and system pathology in COVID-19 Open

Muhammad Jamal, Hina Iqbal Bangash, Maria Habiba, Yufei Lei, Tian Xie , et al. · 2021

Medicine

The coronavirus disease 19 (COVID-19) caused by the novel coronavirus known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021, 87,640,402 confirmed cases and 1,891,692 mortalities have been reported worldwide. St…

Targeting chemokines for acute lymphoblastic leukemia therapy Open

Zixi Hong, Zimeng Wei, Tian Xie, Lin Fu, Jiaxing Sun , et al. · 2021

Medicine

Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various signaling molecules such as cytokines and adhesion molecules …

Immune dysregulation and system pathology in COVID-19 Open

Muhammad Jamal, Hina Iqbal Bangash, Maria Habiba, Yufei Lei, Tian Xie , et al. · 2021

Biology Medicine

The coronavirus disease 19 (COVID-19) caused by the novel coronavirus known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021, 87,640,402 confirmed cases and 1,891,692 mortalities have been reported worldwide. St…

Novel biomarkers for the prediction of COVID-19 progression a retrospective, multi-center cohort study Open

Yalan Yu, Tao Liu, Liang Shao, Xinyi Li, Colin K. He , et al. · 2020

Medicine Biology Physics

A pandemic designated as Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. Up to date, there is no efficient biomarker for the timely prediction of the disea…

Curcumin enhances anti‑cancer efficacy of either gemcitabine or docetaxel on pancreatic cancer cells Open

Pan Liu, Qian Ying, Huan Liu, Siqi Yu, Luping Bu , et al. · 2020

Chemistry Medicine

Curcumin is a natural compound extracted from turmeric (Curcuma longa), which has been reported to be a promising anti‑cancer drug in various human cancers. However, the effects of combination treatment of curcumin with gemcitabine or doce…

Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19 Open

Yingjie Wu, Xiaoxing Huang, Jiaxing Sun, Tian Xie, Yufei Lei , et al. · 2020

Medicine

The dysregulation of CD3 + CD8 + T lymphocytes, CD16 + CD56 + NK cells, C1q as well as IL-6, along with bacterial coinfection, were important causes of exacerbation of the patients’ condition and death.

Scoring systems for predicting mortality for severe patients with COVID-19 Open

Yufeng Shang, Tao Liu, Yongchang Wei, Jingfeng Li, Liang Shao , et al. · 2020

Medicine

This work was supported by the Key Project for Anti-2019 novel Coronavirus Pneumonia from the Ministry of Science and Technology, China (grant number 2020YFC0845500).

Novel Insights Into Illness Progression and Risk Profiles for Mortality in Non-survivors of COVID-19 Open

Liang Shao, Xinyi Li, Yi Zhou, Yalan Yu, Yanan Liu , et al. · 2020

Medicine

Background. The outbreak of COVID-19 has attracted the attention of the whole world. Our study aimed to describe illness progression and risk profiles for mortality in non-survivors. Methods. We retrospectively analyzed 155 patients with C…

Recent Progress on Circular RNA Research in Acute Myeloid Leukemia Open

Muhammad Jamal, Tianbao Song, Bei Chen, Muhammad Faisal, Zixi Hong , et al. · 2019

Medicine Biology Philosophy

Acute myeloid leukemia (AML) is a myeloid malignancy characterized by the proliferation of abnormal and immature myeloid blasts in the bone marrow. Circular RNA (circRNA) is a novel class of long non-coding RNA with a stable circular confo…

Isolation and characterization of spontaneously immortalized B‐lymphocyte lines from HIV‐infected patients with and without non‐Hodgkin's Lymphoma Open

Ke Zhuang, Yongxi Zhang, Li Zhou, Xiaoying Qi, Xi-Qiu Xu , et al. · 2019

Medicine Biology

Isolation of viable circulating tumor cells (CTC) holds the promise for improving screening, early diagnosis, and personalized treatment of lymphoma. In this study, we isolated and characterized spontaneously immortalized B‐lymphocyte (SIB…

An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease Open

Liang Shao, Shan Pan, Qiuping Zhang, Muhammad Jamal, Luhua Chen , et al. · 2019

Biology Medicine

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complicat…

ASXL1 mutations in Chinese patients with essential thrombocythemia Open

Yanbo Nie, Meng Sun, Colin He, Mankai Ju, Fuling Zhou , et al. · 2018

Medicine Biology

Essential thrombocythemia (ET) is characterized by thrombotic and hemorrhagic events. The association of clinical characteristics of Chinese ET patients and additional sex combs like 1 (ASXL1) mutations in these patients has remained to be…

Bioinformatic analysis of prognostic value of ZW10 interacting protein in lung cancer Open

Wen Yuan, Songping Xie, Meng Wang, Shan Pan, Xiaoxing Huang , et al. · 2018

Medicine Biology

ZWINT is aberrantly highly expressed in lung tumor tissues and might be involved in the pathogenesis of lung cancer.

Angiotensin II aggravates lipopolysaccharide induced human pulmonary microvascular endothelial cells permeability in high glucose status Open

Min Chen, Chang Chen, Xiaohui Yuan, Xiaoqi Chen, Feng Zheng , et al. · 2018

Medicine Biology

Lung infection is one of the most common infections in diabetes mellitus and is characterized by increased pulmonary microvascular endothelial permeability. Local Angiotensin II (AngII) plays an important role in the pathogenesis of lung d…

Synergistic effects of baicalein with gemcitabine or docetaxel on the proliferation, migration and apoptosis of pancreatic cancer cells Open

Pan Liu, Jiarui Feng, Meng Sun, Wen Yuan, R. Xiao , et al. · 2017

Chemistry Medicine

Baicalein, a type of flavonoids extracted from Scutellaria baicalensis Georgi, has been reported to be a very promising drug for pancreatic cancer. However, it is unclear whether combination of baicalein with gemcitabine or docetaxel is sy…

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