Limin Xing
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View article: Cyclosporine A improves survival in lower-risk hypoplastic myelodysplastic syndromes: a single-center retrospective study from China
Cyclosporine A improves survival in lower-risk hypoplastic myelodysplastic syndromes: a single-center retrospective study from China Open
CsA provides superior response durability, survival outcomes, and safety compared with other approaches, supporting its use as first-line therapy in lower-risk hMDS. Integration of immune and molecular profiling may refine individualized t…
View article: The efficacy and safety of luspatercept in patients with low-blasts myelodysplastic neoplasms in real world
The efficacy and safety of luspatercept in patients with low-blasts myelodysplastic neoplasms in real world Open
Backgroud: Myelodysplastic neoplasms (MDS) are characterized by myelodysplasia and ineffective hematopoiesis leading to refractory cytopenia. Most of MDS patients had anemia at diagnosis requiring red blood cell (RBC) transfusion, which wa…
View article: Integration of Multiple Mass Spectrometry Techniques and Molecular Network Analysis With Bioinformatics Approaches Revealed the Mechanism of Jiuwei Xifeng Granules in the Treatment of Tourette's Syndrome
Integration of Multiple Mass Spectrometry Techniques and Molecular Network Analysis With Bioinformatics Approaches Revealed the Mechanism of Jiuwei Xifeng Granules in the Treatment of Tourette's Syndrome Open
Rationale Jiuwei Xifeng Granules, a Chinese patent medicine developed based on renowned traditional Chinese medicine, has shown significant clinical efficacy in treating Tourette's syndrome. However, there is limited research on its pharma…
View article: A master gene for Drosophila male courtship prevents the behavior in females via a truncated protein
A master gene for Drosophila male courtship prevents the behavior in females via a truncated protein Open
Decades of studies have established that a terminal gene in the sex determination hierarchy, fruitless (fru), controls nearly all aspects of male courtship behaviors in Drosophila and many other insects. fru is transcribed in a sex-specifi…
View article: Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome
Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome Open
MDS patients have accelerated senescence of bone marrow erythrocyte precursors, which is related to their anaemia. The observed correlation underscores the potential significance of senescence-targeted interventions in managing anaemia in …
View article: Multiomics-based analysis of key genes, metabolites and pathways unveils mechanism associated with social rank in Chickens
Multiomics-based analysis of key genes, metabolites and pathways unveils mechanism associated with social rank in Chickens Open
Social rank plays a crucial role in shaping physiological, psychological and immune responses in animals. Our previous study found that gut microbes and short-chain fatty acids as well as brain neurotransmitters are involved with the mecha…
View article: From Severe Aplastic Anemia with TERT Variant to Wilson Disease - Associations or Not
From Severe Aplastic Anemia with TERT Variant to Wilson Disease - Associations or Not Open
Severe aplastic anemia is a life-threatening ineffective hematopoiesis, arising from inherited or acquired traits. Wilson disease is a rare congenital metabolic disorder with copper accumulation. Here we report a rare case of a 15 year-old…
View article: Molecular landscape of CD8+ T cells in pure red cell aplasia
Molecular landscape of CD8+ T cells in pure red cell aplasia Open
The aberrant function of lymphocytes is considered a significant contributing factor to pure red cell aplasia (PRCA), but the precise mechanism by which T lymphocytes induce erythroid development stagnation remains unclear. In our study, t…
View article: Loss of <scp>FTH1</scp> Induces Ferritinophagy‐Mediated Ferroptosis in Anaemia of Myelodysplastic Syndromes
Loss of <span>FTH1</span> Induces Ferritinophagy‐Mediated Ferroptosis in Anaemia of Myelodysplastic Syndromes Open
Single‐cell sequencing of lineage negative (Lin‐) cells from patients with myelodysplastic syndromes (MDS) revealed a reduction in ferritin heavy chain 1 ( FTH1 ) levels, yet the significance of this decrease in FTH1 in the pathophysiology…
View article: [Efficacy and safety of eltrombopag in the treatment of primary immune thrombocytopenia: real-world data from a single medical center].
[Efficacy and safety of eltrombopag in the treatment of primary immune thrombocytopenia: real-world data from a single medical center]. Open
Objective: This study aimed at investigating the efficacy and safety of eltrombopag in the treatment of adult primary immune thrombocytopenia (ITP) and evaluated the factors influencing its efficacy and side effects. Methods: A total of 19…
View article: A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) in <i>Drosophila</i>
A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) in <i>Drosophila</i> Open
Social enrichment or social isolation affects a range of innate behaviors, such as sex, aggression, and sleep, but whether there is a shared mechanism is not clear. Here, we report a neural mechanism underlying social modulation of spontan…
View article: [Evaluation of the efficacy and safety of intravenous infusion of ferric derisomaltose in the treatment of iron deficiency anemia: a single-center retrospective analysis].
[Evaluation of the efficacy and safety of intravenous infusion of ferric derisomaltose in the treatment of iron deficiency anemia: a single-center retrospective analysis]. Open
Objective: To investigate the clinical efficacy and safety of ferric derisomaltose injection versus iron sucrose injection in the treatment of iron deficiency anemia (IDA) . Methods: A total of 120 patients with iron deficiency anemia admi…
View article: Single-institution experience of venetoclax combined with azacitidine in newly diagnosed acute myeloid leukemia patients
Single-institution experience of venetoclax combined with azacitidine in newly diagnosed acute myeloid leukemia patients Open
To retrospectively analyze the efficacy and safety of venetoclax combined with azacitidine (VEN + AZA) in the treatment of elderly patients with acute myeloid leukemia. The clinical data for 57 AML patients treated with the VEN + AZA regim…
View article: Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia
Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia Open
The ceRNA network of miRNA, lncRNA, and mRNA in peripheral CD19 + B lymphocytes plays an essential role in the pathogenesis of ITP.
View article: A pilot study of orelabrutinib treatment in three cases of refractory/relapsed autoimmune haemolytic anaemia/Evans syndrome
A pilot study of orelabrutinib treatment in three cases of refractory/relapsed autoimmune haemolytic anaemia/Evans syndrome Open
Summary Currently, there is no effective treatment for refractory/relapsed (R/R) autoimmune haemolytic anaemia (AIHA), associated with poor quality of life. Bruton tyrosine kinase inhibitors have begun to be used in some autoimmune disease…
View article: P715: TOX REGULATED CD8+ T LYMPHOCYTES EXHAUSTED IN MYELODYSPLASTIC SYNDROMES PATIENTS THROUGH ACTIVATING AKT/PI3K/MTOR PATHWAY
P715: TOX REGULATED CD8+ T LYMPHOCYTES EXHAUSTED IN MYELODYSPLASTIC SYNDROMES PATIENTS THROUGH ACTIVATING AKT/PI3K/MTOR PATHWAY Open
Background: CD8+ T lymphocytes of myelodysplastic syndromes (MDS) patients are frequently exhausted, which plays a key role in the pathogenesis of MDS. Thymocyte selection-related high mobility box protein (TOX) programs CD8+ T lymphocyte …
View article: Genome-wide DNA methylation profiles analysis in primary warm autoimmune hemolytic anemia patients
Genome-wide DNA methylation profiles analysis in primary warm autoimmune hemolytic anemia patients Open
The DNA methylation spectrum of B cells in AIHA patients is different from that of HC, and the proportion of hypo-methylation regions is higher than that of HC. DMR-related genes are mainly related to some signaling pathways.
View article: [Role and clinical significance of MUC4 gene mutations in thrombotic events in patients with classic paroxysmal nocturnal hemoglobinuria].
[Role and clinical significance of MUC4 gene mutations in thrombotic events in patients with classic paroxysmal nocturnal hemoglobinuria]. Open
Objective: This study aimed to investigate the role and clinical significance of MUC4 gene mutations in thrombotic events in patients with classic paroxysmal nocturnal hemoglobinuria (PNH) patients. Methods: A retrospective analysis was co…
View article: Liposome doxorubicin attenuates cardiotoxicity by reducing ferritinophagy
Liposome doxorubicin attenuates cardiotoxicity by reducing ferritinophagy Open
Background Doxorubicin (DOX) is widely used in lymphoma, myeloma, breast cancer, and other malignant tumors, and it significantly improves the prognosis of these patients. However, its side effects, especially cardiotoxicity, must be taken…
View article: Iron metabolism abnormalities in autoimmune hemolytic anemia and <i>Jianpishengxue keli</i> can ameliorate hemolysis and improve iron metabolism in AIHA mouse models
Iron metabolism abnormalities in autoimmune hemolytic anemia and <i>Jianpishengxue keli</i> can ameliorate hemolysis and improve iron metabolism in AIHA mouse models Open
Iron metabolism abnormalities exists in AIHA patients and Jianpishengxue keli can ameliorate hemolysis and improve iron metabolism in AIHA mouse models.KEY MESSAGESIron metabolism abnormalities exists in hemolytic episode AIHA patients. He…
View article: Relationship Between Workplace Bullying, Spirituality And Job Burnout In Pediatric Nurses: A Cross-Sectional Study
Relationship Between Workplace Bullying, Spirituality And Job Burnout In Pediatric Nurses: A Cross-Sectional Study Open
Background: Workplace bullying threatens public health as a serious social problem globally. The nursing field is one of the hardest hit areas where bullying is breeding. The purpose of this study was to investigate the relationships and p…
View article: Case Report: Sirolimus Alleviates Persistent Cytopenia After CD19 CAR-T-Cell Therapy
Case Report: Sirolimus Alleviates Persistent Cytopenia After CD19 CAR-T-Cell Therapy Open
Chimeric antigen receptor T (CAR-T) cells show good efficacy in the treatment of relapsed and refractory B-cell tumors, such as acute B-cell leukemia (ALL) and diffuse large B-cell lymphoma (DLBCL). The main toxicities of CAR-T include cyt…
View article: Increased Circulating CD4+CXCR5+ Cells and IgG4 Levels in Patients with Myelodysplastic Syndrome with Autoimmune Diseases
Increased Circulating CD4+CXCR5+ Cells and IgG4 Levels in Patients with Myelodysplastic Syndrome with Autoimmune Diseases Open
Objectives. Immune abnormalities play an important role in the pathogenesis and progression of myelodysplastic syndrome (MDS). Some patients with MDS have autoimmune diseases (AI). Follicular helper T (Tfh) cells help B cells produce antib…