Lina Yao
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View article: Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair
Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair Open
After myocardial infarction, the myocardial microenvironment is altered by cardiomyocyte loss, inflammation, and extracellular matrix degradation, creating a hostile environment that severely limits bone marrow‐derived mesenchymal stem cel…
View article: The Secreted Metabolite Isopentenyladenine from <i>Faecalibacterium prausnitzii</i> Mitigates Gut Inflammation
The Secreted Metabolite Isopentenyladenine from <i>Faecalibacterium prausnitzii</i> Mitigates Gut Inflammation Open
Colonic microbiome dysbiosis is correlated with inflammatory bowel disease (IBD), and depletion of the commensal bacterium Faecalibacterium prausnitzii ( F. prausnitzii ) is routinely observed in the metagenomic analyses of IBD patient mic…
View article: Let-7i-3p inhibits the progression of gastric cancer by targeting CCND1 and suppressing the NF-κB signaling pathway
Let-7i-3p inhibits the progression of gastric cancer by targeting CCND1 and suppressing the NF-κB signaling pathway Open
Gastric cancer (GC) often presents as a malignant tumor of the human digestive system. Let-7i-3p has been confirmed to participate in the regulation of various cancers, while the biological mechanisms of Let-7i-3p in GC remains unknown. In…
View article: The Hole Structure of Cellulose Acetate Membrane Evaluated by Position Annihilation and Electrochemical Impedance Spectroscopy
The Hole Structure of Cellulose Acetate Membrane Evaluated by Position Annihilation and Electrochemical Impedance Spectroscopy Open
In this paper, cellulose acetate (CA) membranes were irradiated by electron beam. The hole structural of the membranes at different irradiation doses was characterized by electrochemical impedance spectroscopy (EIS) and positron annihilati…
View article: Relationship of vegetarianism with body weight loss and ASCVD
Relationship of vegetarianism with body weight loss and ASCVD Open
Introduction The association between a plant-based diet and weight loss and atherosclerotic cardiovascular disease (ASCVD) has not been fully elucidated. We performed a pooled analysis and Mendelian randomization (MR) analysis to investiga…
View article: HDL-C mediates the causal relationship between serum urate and aortic aneurysm: a Mendelian randomization study
HDL-C mediates the causal relationship between serum urate and aortic aneurysm: a Mendelian randomization study Open
Background and purpose: Studies have indicated a close relationship between serum urate and an increased risk of aortic aneurysm or aortic dissection. However, the causality between them and the mediators of this association have not been …
View article: A Bacterial Bile Acid Metabolite Modulates T<sub>reg</sub>Activity through the Nuclear Hormone Receptor NR4A1
A Bacterial Bile Acid Metabolite Modulates T<sub>reg</sub>Activity through the Nuclear Hormone Receptor NR4A1 Open
SUMMARY Bile acids act as signaling molecules that regulate immune homeostasis, including the differentiation of CD4 + T cells into distinct T cell subsets. The bile acid metabolite isoallolithocholic acid (isoalloLCA) enhances the differe…
View article: Human gut bacteria produce T<sub>H</sub>17-modulating bile acid metabolites
Human gut bacteria produce T<sub>H</sub>17-modulating bile acid metabolites Open
The microbiota plays a pivotal role in gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17a (T H 17 cells). We previously reported that the bile a…
View article: Micro-RNA 205-5p is Involved in the Progression of Gastric Cancer and Targets Phosphatase and Tensin Homolog (PTEN) in SGC-7901 Human Gastric Cancer Cells
Micro-RNA 205-5p is Involved in the Progression of Gastric Cancer and Targets Phosphatase and Tensin Homolog (PTEN) in SGC-7901 Human Gastric Cancer Cells Open
BACKGROUND This study aimed to investigate the role of micro-RNA 205-5p (miR-205-5p) in the progression of gastric cancer, and the target of miR-205-5p in human gastric cancer cells in vitro. MATERIAL AND METHODS Expression of miR-205-5p a…
View article: Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases
Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases Open
Bile salt hydrolase (BSH) enzymes are widely expressed by human gut bacteria and catalyze the gateway reaction leading to secondary bile acid formation. Bile acids regulate key metabolic and immune processes by binding to host receptors. T…
View article: Aldehyde Dehydrogenase 2 Anti-Sense in the Ventral Tegmental Area Reduces Alcohol Drinking
Aldehyde Dehydrogenase 2 Anti-Sense in the Ventral Tegmental Area Reduces Alcohol Drinking Open
Background: We have reported that aldehyde dehydrogenase 2 (ALDH2) inhibitors suppress alcohol seeking and drinking in rats even in the absence of alcohol and acetaldehyde. These behavioural changes suggest that ALDH2 in brain could be a t…
View article: Ionic Current Rectification by Laminated Bipolar Silica Isoporous Membrane
Ionic Current Rectification by Laminated Bipolar Silica Isoporous Membrane Open
Ionic current rectification (ICR) is one of interesting characteristics displayed by nanochannels with asymmetric geometry, ionic concentration or charge distribution, which has been utilized for the development of chemical sensors and bio…
View article: A selective gut bacterial bile salt hydrolase alters host metabolism
A selective gut bacterial bile salt hydrolase alters host metabolism Open
The human gut microbiota impacts host metabolism and has been implicated in the pathophysiology of obesity and metabolic syndromes. However, defining the roles of specific microbial activities and metabolites on host phenotypes has proven …
View article: Author response: A selective gut bacterial bile salt hydrolase alters host metabolism
Author response: A selective gut bacterial bile salt hydrolase alters host metabolism Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The human gut microbiota impa…
View article: Growth bottlenecks of microalga <i>Dunaliella tertiolecta</i> in response to an up-shift in light intensity
Growth bottlenecks of microalga <i>Dunaliella tertiolecta</i> in response to an up-shift in light intensity Open
Microalgae are a potential source of valuable products including drugs, chemicals, food supplements, biofuels, animal feed and fertilizers. In outdoor culture, biomass productivity is dependent on how well the microalgae respond to fluctua…
View article: RNAi-mediated silencing of a pyruvate dehydrogenase kinase enhances triacylglycerol biosynthesis in the oleaginous marine alga Nannochloropsis salina
RNAi-mediated silencing of a pyruvate dehydrogenase kinase enhances triacylglycerol biosynthesis in the oleaginous marine alga Nannochloropsis salina Open
Oleaginous microalgae have been emerging as the third-generation feedstocks for biofuel production. Genetic manipulation for improving triacylglycerol (TAG) accumulation represents a promising approach towards the economics of microalgal b…
View article: Elevated acetyl‐CoA by amino acid recycling fuels microalgal neutral lipid accumulation in exponential growth phase for biofuel production
Elevated acetyl‐CoA by amino acid recycling fuels microalgal neutral lipid accumulation in exponential growth phase for biofuel production Open
Summary Microalgal neutral lipids [mainly in the form of triacylglycerols ( TAG s)], feasible substrates for biofuel, are typically accumulated during the stationary growth phase. To make microalgal biofuels economically competitive with f…
View article: Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment Open
Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that crosslinks collagen—Lysyl oxidase-like 2 (Loxl2)—is essential for interstitial fibrosis and mechanical dysfunctio…
View article: Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII
Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII Open
Late INa exerts distinct effects on Ca(2+) homeostasis in atrial myocardium through activation of CaMKII and PKA. Inhibition of late INa represents a potential approach to attenuate CaMKII activation and decreases SR-Ca(2+)-leak in atrial …