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View article: Multidimensional dynamic optical imaging unveils anesthetic-driven hemispheric lateralization in blood-brain barrier homeostasis
Multidimensional dynamic optical imaging unveils anesthetic-driven hemispheric lateralization in blood-brain barrier homeostasis Open
The blood-brain barrier (BBB) is commonly known to be distributed evenly within the central nervous system. This study elucidates previously unexplored physiological phenomena associated with the spatial heterogeneity of the BBB. We found …
View article: Optical imaging unveils morphological heterogeneity at the hepatic lobule level during metabolic dysfunction-associated fatty liver disease progression [Invited]
Optical imaging unveils morphological heterogeneity at the hepatic lobule level during metabolic dysfunction-associated fatty liver disease progression [Invited] Open
Hepatic lobules constitute the fundamental structural and functional units of the liver, which are essential for maintaining microcirculatory homeostasis, barrier integrity, and metabolic clearance. Optical imaging techniques, including ph…
View article: Multi-parametric photoacoustic elastomicroscopy: quantitative elasticity mapping and microstructural analysis for early-stage hepatic fibrosis detection
Multi-parametric photoacoustic elastomicroscopy: quantitative elasticity mapping and microstructural analysis for early-stage hepatic fibrosis detection Open
Early detection of hepatic fibrosis remains a critical unmet need due to the limited sensitivity of conventional elastography in capturing microstructural and biomechanical changes. In this study, we developed photoacoustic elastomicroscop…
View article: Tumor metabolome remolded by low dose mitochondrial uncoupler elicites robust CD8+ T cell response
Tumor metabolome remolded by low dose mitochondrial uncoupler elicites robust CD8+ T cell response Open
Tumor cells balance ATP production and carbon skeleton synthesis by flexibly altering catabolic pathways to sustain their significant growth advantage. Uncouplers have shown potential for tumor suppression by converting chemical energy fro…
View article: Simultaneous imaging of astrocyte behavior and hemodynamic activities using a near-infrared fluorescent protein based photoacoustic microscopy
Simultaneous imaging of astrocyte behavior and hemodynamic activities using a near-infrared fluorescent protein based photoacoustic microscopy Open
Astrocytes have the important ability to delivery oxygen and glucose from intravascular sources to neurons, due to its interposed location between the neurons and the micro-vessels in the brain. As the primary cellular component of the blo…
View article: Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia
Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia Open
Volatile anesthetics have been widely applied during surgery, but the potential mechanisms by which they influence loss of consciousness (LOC), anesthesia maintenance, and recovery of consciousness (ROC) from anesthesia remain largely unkn…
View article: Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma
Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma Open
Lenvatinib, endorse as a first‐line targeted therapy, has demonstrated efficacy in extending the survival span of individuals afflicted with advanced Hepatocellular carcinoma (HCC). However, its therapeutic effect wears off with time, whic…
View article: Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system Open
Cell death-based therapies combined with immunotherapy have great potential in cancer therapy. To further explore and apply the combined therapies, the immunogenicity of different cell death modes in colorectal cancer (CRC) was evaluated b…
View article: Collagen fibers quantification for liver fibrosis assessment using linear dichroism photoacoustic microscopy
Collagen fibers quantification for liver fibrosis assessment using linear dichroism photoacoustic microscopy Open
Liver fibrosis represents a progressive pathological condition that can culminate in severe hepatic dysfunction, potentially advancing to cirrhosis and liver cancer. The extent of liver fibrosis is intrinsically associated with the quantit…
View article: Ischemic Area‐Targeting and Self‐Monitoring Nanoprobes Ameliorate Myocardial Ischemia/Reperfusion Injury by Scavenging ROS and Counteracting Cardiac Inflammation
Ischemic Area‐Targeting and Self‐Monitoring Nanoprobes Ameliorate Myocardial Ischemia/Reperfusion Injury by Scavenging ROS and Counteracting Cardiac Inflammation Open
Precise and effective management of myocardial ischemia/reperfusion injury (MIRI) is still a formidable challenge in clinical practice. Additionally, real‐time monitoring of drug aggregation in the MIRI region remains an open question. Her…
View article: Amphiphilic hemicyanine molecular probes crossing the blood-brain barrier for intracranial optical imaging of glioblastoma
Amphiphilic hemicyanine molecular probes crossing the blood-brain barrier for intracranial optical imaging of glioblastoma Open
Intracranial optical imaging of glioblastoma (GBM) is challenging due to the scarcity of effective probes with blood-brain barrier (BBB) permeability and sufficient imaging depth. Herein, we describe a rational strategy for designing optic…
View article: SoK: Detection and Repair of Accessibility Issues
SoK: Detection and Repair of Accessibility Issues Open
There is an increasing global emphasis on information accessibility, with numerous researchers actively developing automated tools to detect and repair accessibility issues, thereby ensuring that individuals with diverse abilities can inde…
View article: Quantitative evaluation of microenvironmental changes and efficacy of cupping therapy under different pressures based on photoacoustic imaging
Quantitative evaluation of microenvironmental changes and efficacy of cupping therapy under different pressures based on photoacoustic imaging Open
Cupping therapy, a traditional Chinese medicinal practice, has been subjected to scientific scrutiny to validate its effects on local tissue microenvironments. This study provides a quantitative assessment of cupping therapy at different n…
View article: Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo
Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo Open
Advancements in precision medicine necessitate understanding drug clearance pathways, especially in organs like the liver and kidneys. Traditional techniques such as PET/CT pose radiation hazards, whereas optical imaging poses challenges i…
View article: Diagnostic and therapeutic optical imaging in cardiovascular diseases
Diagnostic and therapeutic optical imaging in cardiovascular diseases Open
Cardiovascular disease (CVD) is one of the most prevalent health threats globally. Traditional diagnostic methods for CVDs, including electrocardiography, ultrasound, and cardiac magnetic resonance imaging, have inherent limitations in rea…
View article: Direct Monitoring of Whole‐Brain Electrodynamics via High‐Spatiotemporal‐Resolution Photoacoustics with Voltage‐Sensitive Dye
Direct Monitoring of Whole‐Brain Electrodynamics via High‐Spatiotemporal‐Resolution Photoacoustics with Voltage‐Sensitive Dye Open
Brain voltage plays a crucial role in indicating internal functions or diseases, and optical voltage imaging has gained intensive attention in recent years. Despite encouraging progress, current implementations encounter limitations pertai…
View article: An overview of Web3 technology: Infrastructure, applications, and popularity
An overview of Web3 technology: Infrastructure, applications, and popularity Open
Web3, the next generation of the Internet, represents a decentralized and democratized web. Although it has garnered significant public interest and found numerous real-world applications, there is a limited understanding of people's perce…
View article: In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging
In vivo liver function reserve assessments in alcoholic liver disease by scalable photoacoustic imaging Open
We present a rapid and high-resolution photoacoustic imaging method for evaluating the liver function reserve (LFR). To validate its accuracy, we establish alcoholic liver disease (ALD) models and employ dual-wavelength spectral unmixing t…
View article: A Comprehensive Study on Quality Assurance Tools for Java
A Comprehensive Study on Quality Assurance Tools for Java Open
Quality assurance (QA) tools are receiving more and more attention and are\nwidely used by developers. Given the wide range of solutions for QA technology,\nit is still a question of evaluating QA tools. Most existing research is\nlimited …
View article: Score-based Generative Models for Photoacoustic Image Reconstruction with Rotation Consistency Constraints
Score-based Generative Models for Photoacoustic Image Reconstruction with Rotation Consistency Constraints Open
Photoacoustic tomography (PAT) is a newly emerged imaging modality which enables both high optical contrast and acoustic depth of penetration. Reconstructing images of photoacoustic tomography from limited amount of senser data is among on…
View article: LMs: Understanding Code Syntax and Semantics for Code Analysis
LMs: Understanding Code Syntax and Semantics for Code Analysis Open
Large language models~(LLMs) demonstrate significant potential to revolutionize software engineering (SE) by exhibiting outstanding performance in SE tasks such as code and document generation. However, the high reliability and risk contro…
View article: A systematic mapping study for graphical user interface testing on mobile apps
A systematic mapping study for graphical user interface testing on mobile apps Open
Mobile apps with tested Graphical User Interface (GUI) tend to have higher downloads in the apps store. In recent years, few efforts were made to analyse the research community and research status of the literature for GUI testing on mobil…
View article: Label-free differential imaging of cellular components in mouse brain tissue by wide-band photoacoustic microscopy
Label-free differential imaging of cellular components in mouse brain tissue by wide-band photoacoustic microscopy Open
Mapping diverse cellular components with high spatial resolution is important to interrogate biological systems and study disease pathogenesis. Conventional optical imaging techniques for mapping biomolecular profiles with differential sta…
View article: In vivo characterization and analysis of glioblastoma at different stages using multiscale photoacoustic molecular imaging
In vivo characterization and analysis of glioblastoma at different stages using multiscale photoacoustic molecular imaging Open
Simultaneous spatio-temporal description of tumor microvasculature, blood-brain barrier, and immune activity is pivotal to understanding the evolution mechanisms of highly aggressive glioblastoma, one of the most common primary brain tumor…
View article: Cross-domain Self-supervised Framework for Photoacoustic Computed Tomography Image Reconstruction
Cross-domain Self-supervised Framework for Photoacoustic Computed Tomography Image Reconstruction Open
Accurate image reconstruction is crucial for photoacoustic (PA) computed tomography (PACT). Recently, deep learning has been used to reconstruct the PA image with a supervised scheme, which requires high-quality images as ground truth labe…
View article: The Impact of Text Generation Techniques on Neural Image Captioning: An Empirical Study
The Impact of Text Generation Techniques on Neural Image Captioning: An Empirical Study Open
Image captioning is an advanced NLP task that has various practical applications. To meet the requirement of visual information understanding and textual information generation, the encoder-decoder framework has been widely adopted by imag…
View article: Analysis of Nuclear Power Economy and Its Influencing Factors
Analysis of Nuclear Power Economy and Its Influencing Factors Open
The improvement of nuclear power economy is indispensable to the safe and efficient development of nuclear power. This paper explores the scope of economic evaluation of nuclear power based on literature and actual project operation. The e…
View article: Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography
Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography Open
Intravenous injection is a rapid, low-cost, and direct method that is commonly used to deliver multifarious biotherapeutics and vaccines. However, intravenous injection often causes trauma or tissue injury that requires professional operat…