Liming Ouyang
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View article: Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751
Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751 Open
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characteris…
View article: Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases
Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases Open
Sesquiterpenoids served as an important source for natural product drug discovery. Although genome mining approaches have revealed numerous novel sesquiterpenoids and biosynthetic enzymes, the comprehensive landscape of fungal sesquiterpen…
View article: Process Mineralogy of Lithium and Rubidium in the Diantan Polymetallic Mining Area, Tengchong, Southwest China
Process Mineralogy of Lithium and Rubidium in the Diantan Polymetallic Mining Area, Tengchong, Southwest China Open
Highly differentiated granite often contains abundant key metal resources, such as lithium and rubidium. The Tengchong area of Yunnan hosts a large number of highly differentiated granites from the Cretaceous age. Among these, granite samp…
View article: Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket
Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket Open
Fungal bifunctional terpene synthases (BFTSs) catalyze the formation of numerous di-/sester-/tri-terpenes skeletons. However, the mechanism in controlling the cyclization pattern of terpene scaffolds is rarely deciphered for further applic…
View article: Expanding Catalytic Promiscuity of a Bifunctional Terpene Synthase Through a Single Mutation-Induced Change in Hydrogen-Bond Network within the Catalytic Pocket
Expanding Catalytic Promiscuity of a Bifunctional Terpene Synthase Through a Single Mutation-Induced Change in Hydrogen-Bond Network within the Catalytic Pocket Open
View article: Efficient expansion and delayed senescence of hUC-MSCs by microcarrier–bioreactor system
Efficient expansion and delayed senescence of hUC-MSCs by microcarrier–bioreactor system Open
Background Human umbilical cord mesenchymal stem cells (hUC-MSCs) are widely used in cell therapy due to their robust immunomodulatory and tissue regenerative capabilities. Currently, the predominant method for obtaining hUC-MSCs for clini…
View article: Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against H2O2-Induced Senescence
Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against H2O2-Induced Senescence Open
Human umbilical cord mesenchymal stem cells (hUC-MSCs) are broadly applied in clinical treatment due to convenient accessibility, low immunogenicity, and the absence of any ethical issues involved. However, the microenvironment of inflamma…
View article: Geochronology and geochemistry of ore-hosted zircon reveal the genesis of typical Sb-(Au-W) deposits in South China
Geochronology and geochemistry of ore-hosted zircon reveal the genesis of typical Sb-(Au-W) deposits in South China Open
The Xikuangshan and Woxi Sb-(Au-W) deposits are the most important Sb-related mineralization in the Xiangzhong metallogenic province, South China. In this study, trace element, U-Pb dating, and Hf isotopic results of zircon in typical ore …
View article: Enhancement of fatty acid degradation pathway promoted glucoamylase synthesis in Aspergillus niger
Enhancement of fatty acid degradation pathway promoted glucoamylase synthesis in Aspergillus niger Open
Background Our recent multi-omics analyses of glucoamylase biosynthesis in Aspergillus niger ( A. niger ) suggested that lipid catabolism was significantly up-regulated during high-yield period under oxygen limitation. Since the catabolism…
View article: Integrated pathway engineering and transcriptome analysis for improved astaxanthin biosynthesis in Yarrowia lipolytica
Integrated pathway engineering and transcriptome analysis for improved astaxanthin biosynthesis in Yarrowia lipolytica Open
View article: Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies
Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies Open
View article: Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p
Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p Open
Clinical use of antimicrobials faces great challenges from the emergence of multidrug-resistant pathogens. The overexpression of drug efflux pumps is one of the major contributors to multidrug resistance (MDR). Reversing the function of dr…
View article: Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger
Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger Open
View article: Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger
Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger Open
Background: Nicotinamide adenine dinucleotide phosphate (NADPH) is an important cofactor ensuring intracellular redox balance, anabolism and cell growth in all living systems. Our recent multi-omics analyses of glucoamylase (GlaA) biosynth…
View article: Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger
Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger Open
Background: Nicotinamide adenine dinucleotide phosphate (NADPH) is an important cofactor ensuring intracellular redox balance, anabolism and cell growth in all living systems. Our recent multi-omics analyses of glucoamylase (GlaA) biosynth…
View article: Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p
Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p Open
Clinical use of antimicrobials faces great challenges from the emergence of multidrug resistant (MDR) pathogens. The overexpression of drug efflux pumps is one of the major contributors to MDR. It is considered as a promising approach to o…
View article: Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation
Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation Open
Background Glucoamylase is one of the most industrially applied enzymes, produced by Aspergillus species, like Aspergillus niger . Compared to the traditional ways of process optimization, the metabolic engineering strategies to improve gl…
View article: Genomics course design and combined teaching strategy to enhance learning initiatives in classroom
Genomics course design and combined teaching strategy to enhance learning initiatives in classroom Open
Genomics is a core course for bioscience‐majored undergraduates in many universities. However, the teaching of genomics faces many challenges such as the need for rapid updating of related knowledge, content overlap between genomics and mo…
View article: Efficient gene deletion and replacement in Aspergillus niger by modified in vivo CRISPR/Cas9 systems
Efficient gene deletion and replacement in Aspergillus niger by modified in vivo CRISPR/Cas9 systems Open
View article: Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition
Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition Open
View article: Integrated analysis of the yeast NADPH-regulator Stb5 reveals distinct differences in NADPH requirements and regulation in different states of yeast metabolism
Integrated analysis of the yeast NADPH-regulator Stb5 reveals distinct differences in NADPH requirements and regulation in different states of yeast metabolism Open
The Saccharomyces cerevisiae transcription factor (TF) Stb5 is known to be involved in regulating NADPH generation. We explored its role by combining DNA binding studies with transcriptome analysis at four environmental conditions that wer…
View article: Global transcriptional response of Aspergillus niger in the process of glucoamylase fermentation
Global transcriptional response of Aspergillus niger in the process of glucoamylase fermentation Open
Background In the phase of oxygen limitation during Aspergillus niger fermentation, the cell growth decreased, while the yield of glucoamylase increased continuously and significantly. Explanation on the changes of transcriptome profile du…
View article: MOESM1 of Global transcriptional response of Aspergillus niger in the process of glucoamylase fermentation
MOESM1 of Global transcriptional response of Aspergillus niger in the process of glucoamylase fermentation Open
Additional file 1: Table S1. All differentially expressed genes in the process of glucoamylase fermentation.
View article: Transcriptional Responses to Sucrose Mimic the Plant-Associated Life Style of the Plant Growth Promoting Endophyte Enterobacter sp. 638
Transcriptional Responses to Sucrose Mimic the Plant-Associated Life Style of the Plant Growth Promoting Endophyte Enterobacter sp. 638 Open
Growth in sucrose medium was previously found to trigger the expression of functions involved in the plant associated life style of the endophytic bacterium Enterobacter sp. 638. Therefore, comparative transcriptome analysis between cultur…