Liming Shao
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View article: Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review Open
View article: METTL1-mediated m7G modification promotes colorectal cancer metastasis via stabilization of ICAM-1
METTL1-mediated m7G modification promotes colorectal cancer metastasis via stabilization of ICAM-1 Open
View article: Preliminary outcomes of Neuroform Atlas stent-assisted coiling for intracranial aneurysms with small parent vessels
Preliminary outcomes of Neuroform Atlas stent-assisted coiling for intracranial aneurysms with small parent vessels Open
Background Although stent-assisted coiling has become a standard approach for treating intracranial aneurysms (IAs), there are limited reports on its safety and effectiveness in parent artery less than 2.5 mm in diameter. This study evalua…
View article: Inhibition of TTX-S Na+ currents by a novel blocker QLS-278 for antinociception
Inhibition of TTX-S Na+ currents by a novel blocker QLS-278 for antinociception Open
View article: Discovery of an Ortho-Substituted <i>N</i>-Cyclopropylmethyl-7α-phenyl-6,14-<i>endo</i>ethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect
Discovery of an Ortho-Substituted <i>N</i>-Cyclopropylmethyl-7α-phenyl-6,14-<i>endo</i>ethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect Open
Research into kappa opioid receptor (KOR) agonists with attenuated central-nervous-system side effects is a critical focus for developing productive and safe analgesics. Herein, a series of ortho-substituted N-cyclopropylmeth…
View article: Variations in redox properties of biochar and humic acid induced by interactive molecular exchange
Variations in redox properties of biochar and humic acid induced by interactive molecular exchange Open
Biochar and humic substances are prevalent redox pools in the environment, which is critical to electron transfer in geochemical cycles and pollution control processes. The dissolution of biochar and the sorption of humic substances on bio…
View article: Synthesis of easily-modified and useful dibenzo-[<i>b,d</i>]azepines by palladium(<scp>ii</scp>)-catalyzed cyclization/addition with a green solvent
Synthesis of easily-modified and useful dibenzo-[<i>b,d</i>]azepines by palladium(<span>ii</span>)-catalyzed cyclization/addition with a green solvent Open
An eco-friendly method based on palladium-catalyzed tandem cyclization has been developed to synthesize novel dibenzo[ b,d ]azepines. Then substrates were expanded and a medicinal chemistry project was designed upon with dibenzo[ b,d ]azep…
View article: Mouse Model of Lipopolysaccharide (LPS)-Induced Pulpitis
Mouse Model of Lipopolysaccharide (LPS)-Induced Pulpitis Open
Pulpitis is an important and prevalent disease within the oral cavity. Thus, animal models are necessary tools for basic research focused on pulpitis. Researchers worldwide often use dogs and miniature pigs to construct animal models of pu…
View article: Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone
Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone Open
View article: Design, synthesis, and biological evaluation of acyl sulfonamide derivatives with spiro cycles as NaV1.7 inhibitors for antinociception
Design, synthesis, and biological evaluation of acyl sulfonamide derivatives with spiro cycles as NaV1.7 inhibitors for antinociception Open
View article: Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo
Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo Open
View article: Discovery of Potent and Selective Transient Receptor Potential Vanilloid 1 (TRPV1) Agonists with Analgesic Effects <i>In Vivo</i> Based on the Functional Conversion Induced by Altering the Orientation of the Indazole Core
Discovery of Potent and Selective Transient Receptor Potential Vanilloid 1 (TRPV1) Agonists with Analgesic Effects <i>In Vivo</i> Based on the Functional Conversion Induced by Altering the Orientation of the Indazole Core Open
Transient receptor potential vanilloid 1 (TRPV1) is a promising target for developing antinociceptive agents. Here, we report the synthesis of N-indazole-4-aryl piperazine carboxamide analogues as TRPV1 modulators. The structure-act…
View article: Identification of a Partial and Selective TRPV1 Agonist CPIPC for Alleviation of Inflammatory Pain
Identification of a Partial and Selective TRPV1 Agonist CPIPC for Alleviation of Inflammatory Pain Open
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel, predominantly expressed in a subset of peripheral sensory neurons for pain signaling. Topical application of agonist capsaicin for desensitizing TRPV1 curr…
View article: Primary balloon angioplasty for chronic occlusion of intracranial internal carotid artery: A case report
Primary balloon angioplasty for chronic occlusion of intracranial internal carotid artery: A case report Open
View article: <b>SLL-627</b> Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity
<b>SLL-627</b> Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity Open
Undue central nervous system (CNS) side effects including dysphoria and sedation remain to be a challenge for the development of κ opioid receptor (KOR) agonists as effective and safe analgesics. On the basis of our previous work on morphi…
View article: A nanoscale observation to explain the discrepancy of electron exchange capacities between biochar containing comparable surface redox-active moieties
A nanoscale observation to explain the discrepancy of electron exchange capacities between biochar containing comparable surface redox-active moieties Open
View article: Exposure to Electronic Media, Smoking and Alcohol Drinking Among Guyanese Adults
Exposure to Electronic Media, Smoking and Alcohol Drinking Among Guyanese Adults Open
Use of electronic media has been shown to be associated with tobacco and alcohol consumption behavior among adult population. Currently, not much is known about the risk factors of tobacco and alcohol consumption in Guyana. The present stu…
View article: Release of airborne antibiotic resistance genes from municipal solid waste transfer stations
Release of airborne antibiotic resistance genes from municipal solid waste transfer stations Open
View article: Factors associated with health insurance ownership among women of reproductive age: A multicountry study in sub-Saharan Africa
Factors associated with health insurance ownership among women of reproductive age: A multicountry study in sub-Saharan Africa Open
Background Promoting the coverage and ownership of health insurance constitutes a key strategy to achieving universal healthcare, thereby meeting the Sustainable Development Goal (SDG 3.8) of safeguarding the vulnerable population from fin…
View article: Design, Development and Evaluation of Prodrug-Type TrkA-Selective Inhibitor with Antinociceptive Effects In Vivo
Design, Development and Evaluation of Prodrug-Type TrkA-Selective Inhibitor with Antinociceptive Effects In Vivo Open
View article: Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia
Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia Open
Ulotaront (SEP-363856) is a trace-amine associated receptor 1 (TAAR1) agonist with 5-HT1A receptor agonist activity in Phase 3 clinical development, with FDA Breakthrough Therapy Designation, for the treatment of schizophrenia. TAAR1 is a …
View article: Repercussions of clinical waste co-incineration in municipal solid waste incinerator during COVID-19 pandemic
Repercussions of clinical waste co-incineration in municipal solid waste incinerator during COVID-19 pandemic Open
View article: Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion Open
View article: Discovery of an <i>M</i>-Substituted <i>N</i>-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
Discovery of an <i>M</i>-Substituted <i>N</i>-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile Open
The search for selective kappa opioid receptor (κOR) agonists with an improved safety profile is an area of interest in opioid research. In this work, a series of m-substituted analogs were designed, synthesized, and assayed, result…
View article: Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain
Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain Open
View article: Functional genome-centric view of the CO-driven anaerobic microbiome
Functional genome-centric view of the CO-driven anaerobic microbiome Open
CO is a promising substrate for producing biochemicals and biofuels through mixed microbial cultures, where carboxydotrophs play a crucial role. The previous investigations of mixed microbial cultures focused primarily on overall community…
View article: Responses of Methanosarcina barkeri to acetate stress
Responses of Methanosarcina barkeri to acetate stress Open
View article: A Methanogenic Consortium Was Active and Exhibited Long-Term Survival in an Extremely Acidified Thermophilic Bioreactor
A Methanogenic Consortium Was Active and Exhibited Long-Term Survival in an Extremely Acidified Thermophilic Bioreactor Open
Acid crisis characterized by acid accumulation and/or low pH is a common reason for the failure of anaerobic digestion (AD), which is usually applied for wastewater and waste treatment. Acid-tolerant methanogens are rarely reported to be a…
View article: Discovery of a Highly Selective and Potent κ Opioid Receptor Agonist from <i>N</i>-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message–Address Concept
Discovery of a Highly Selective and Potent κ Opioid Receptor Agonist from <i>N</i>-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message–Address Concept Open
Effective and safe analgesics represent an unmet medical need for the treatment of acute and chronic pain. A series of N-cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines were designed, synthesized, and assayed, lead…
View article: SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action Open
For the past 50 years, the clinical efficacy of antipsychotic medications has relied on blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to avoid the limiting side effects of dopamine r…