Explanipedia

Magnetic sculpture-like tumor cell vaccines enable targeted in situ immune activation and potent antitumor effects Open

Heng Zhang, Qingqing Li, Yue Shi, Lei Zhang, Kaiwen Wang , et al. · 2025

Rationale: Tumor cells are ideal candidates for developing cancer vaccines due to their antigenic profiles, yet existing whole-cell vaccines lack efficacy. This study aimed to develop a novel whole-cell vaccine platform that combine…

Periarteriolar niches become inflamed in aging bone marrow, remodeling the stromal microenvironment and depleting lymphoid progenitors Open

Liming Du, Maria Angelica Freitas-Cortez, Jingzhu Zhang, Yuanyuan Xue, Reshma T Veettil , et al. · 2025

In early postnatal and young adult bone marrow, Leptin receptor–expressing (LepR + ) stromal cells and endothelial cells synthesize factors required for hematopoietic stem cell (HSC) maintenance, including Stem Cell Factor (SCF) and Cxcl12…

Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity Open

Xu Jiang, Jiaqi Wang, Liangyu Lin, Liming Du, Yayun Ding , et al. · 2024

Metabolic inflexibility promotes mitochondrial health during liver regeneration Open

Xun Wang, Cameron J. Menezes, Yuemeng Jia, Yi Xiao, Siva Sai Krishna Venigalla , et al. · 2024

Mitochondria are critical for proper organ function and mechanisms to promote mitochondrial health during regeneration would benefit tissue homeostasis. We report that during liver regeneration, proliferation is suppressed in electron tran…

Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation Open

Liangyu Lin, Mingyuan Hu, Qing Li, Liming Du, Li Lin , et al. · 2023

MHC class Ib–restricted CD8 + T cells possess strong tumoricidal activities Open

Qing Li, Liangyu Lin, Peishun Shou, Keli Liu, Yueqing Xue , et al. · 2023

The importance of classical CD8 + T cells in tumor eradication is well acknowledged. However, the anti-tumor activity of MHC (major histocompatibility complex) Ib-restricted CD8 + T (Ib-CD8 + T) cells remains obscure. Here, we show that CX…

Osteolectin increases bone elongation and body length by promoting growth plate chondrocyte proliferation Open

Jingzhu Zhang, Liming Du, Bethany Davis, Zhimin Gu, Junhua Lyu , et al. · 2023

Osteolectin is a recently identified osteogenic growth factor that binds to Integrin α11 (encoded by Itga11 ), promoting Wnt pathway activation and osteogenic differentiation by bone marrow stromal cells. While Osteolectin and Itga11 are n…

Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow Open

Nergis Kara, Yuanyuan Xue, Zhiyu Zhao, Malea M. Murphy, Stefano Comazzetto , et al. · 2023

Mammalian hematopoietic stem cells (HSCs) colonize the bone marrow during late fetal development, and this becomes the major site of hematopoiesis after birth. However, little is known about the early postnatal bone marrow niche. We perfor…

SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes Open

Yueqing Xue, Liangyu Lin, Qing Li, Keli Liu, Mingyuan Hu , et al. · 2022

Niche for stem cells profoundly influences their maintenance and fate during tissue homeostasis and pathological disorders; however, the underlying mechanisms and tissue‐specific features remain poorly understood. Here, it is reported that…

MHC Class Ia Empowers MHC Class Ib-restricted CD8+ T Cells with Strong Tumoricidal Capacity Open

Yufang Shi, Qing Li, Liangyu Lin, Peishun Shou, Keli Liu , et al. · 2021

The tumoricidal effects of CD8+T cells are well acknowledged, but how MHC Ib-restricted CD8+T (Ib-CD8+T) cells contribute to anti-tumor immunity remains obscure. Here, we show that infusion of MHC Ia+ cells to Kb-/-Db-/- mice induced the e…

Application of Airborne Magnetic Survey in Deep Iron Ore Prospecting—A Case Study of Jinling Area in Shandong Province, China Open

Ning Lu, Guixiang Liao, Yongzai Xi, Hongshan Zheng, Fang Ben , et al. · 2021

With the increasing demand for mineral resources, there is an inevitable trend to carry out deep prospecting in existing old mines to find a second or even third mining space. Deep prospecting is also an affordable and practical way to pro…

The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin Open

Jingzhu Zhang, Adi Cohen, Bo Shen, Liming Du, Alpaslan Tasdogan , et al. · 2021

Significance Only recently have multiple, anabolic, bone-forming agents become available, raising the possibility that osteoporosis might be more effectively treated by combinatorial or sequential treatments rather than single agents. The …

Steroids Enable Mesenchymal Stromal Cells to Promote CD8+ T Cell Proliferation Via VEGF‐C Open

Yurun Gan, Tao Zhang, Xiaohong Chen, Wei Cao, Liangyu Lin , et al. · 2021

Mesenchymal stromal cells (MSCs) function as a formidable regulator of inflammation and tissue homeostasis and expanded MSCs are shown to be effective in treating various inflammatory diseases. Their therapeutic effects require the existen…

A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis Open

Bo Shen, Alpaslan Tasdogan, Jessalyn M. Ubellacker, Jingzhu Zhang, E. D. Nosyreva , et al. · 2021

IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages Open

Xuefeng Wang, Liangyu Lin, Bin Lan, Yu Wang, Liming Du , et al. · 2020

Specific activation of IGF2R inhibits inflammatory diseases via induction of anti-inflammatory macrophages.

Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II Open

Keli Liu, Liangyu Lin, Qing Li, Yueqing Xue, Fanjun Zheng , et al. · 2020

Significance Adipose tissue-derived mesenchymal stem cells (ADSCs) are well-known in the generation of both white and beige adipocytes and the maintenance of adipose tissue homeostasis. Stearoyl-coenzyme A desaturase 1 (Scd1) is a rate-lim…

Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity Open

Yin Huang, Qing Li, Kunshan Zhang, Mingyuan Hu, Yu Wang , et al. · 2019

Mesenchymal stem cells (MSCs) are a population of multipotent cells with a superior ability to promote tissue repair by regulating regeneration and inflammation. Effective application of MSCs in disease treatment relies on the production o…

IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties Open

Liming Du, Liangyu Lin, Qing Li, Keli Liu, Yin Huang , et al. · 2019

Research on Population Distribution Model Based on Real Estate Big Data Open

Jie Dong, Li Gui, Liming Du · 2018

Population distribution is one of the important factors that affects social economic vitality, infrastructure construction, public service allocation, transportation, resources and so on.Obtaining high density urban population distribution…

184 Can Adjunct Use of Topical Provodine® Improve Healing Rates in Patients With Skin Abscesses? Open

Adriana Segura Olson, Lauren Rosenblatt, Nicholas Salerno, Julie Odette, Ronnie Ren , et al. · 2017

The role of secreted factors in stem cells-mediated immune regulation Open

Liangyu Lin, Liming Du · 2017

Stem cells are characterized by self-renew and multipotent differentiation abilities. Besides their roles in cell compensation, stem cells are also rich sources of growth factors, cytokines, chemokines, micro-RNAs and exosomes and serve as…

SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation Open

Menghui Jiang, Chunxing Zheng, Peishun Shou, Na Li, Gang Cao , et al. · 2016

(Cell Reports 16, 769–780; July 19, 2016) The original version of Figure 3 had a duplicated graph in panel H. The statistics graph is now replaced with the correct one. The authors apologize for this error.Figure 3HSHP1, but Not SHP2, Is I…

SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation Open

Menghui Jiang, Chunxing Zheng, Peishun Shou, Na Li, Gang Cao , et al. · 2016

Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities Open

Liangyu Lin, Liming Du, Kai Cao, Yin Huang, Pengfei Yu , et al. · 2016

Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity Open

Kai Cao, Guanghui Wang, Wenzhao Li, L Zhang, R Wang , et al. · 2015

The poor efficacy of the in vivo anti-tumor immune response has been partially attributed to ineffective T-cell responses mounted against the tumor. Fas-FasL-dependent activation-induced cell death (AICD) of T cells is believed to be a maj…

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