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View article: De-escalating first-line treatment in stage IVB or recurrent cervical cancer: outcomes of immunotherapy alone and systemic review
De-escalating first-line treatment in stage IVB or recurrent cervical cancer: outcomes of immunotherapy alone and systemic review Open
Introduction Chemo-immunotherapy (IO) is the preferred first-line treatment for stage IVB or recurrent cervical cancer. However, limited data exist on the efficacy and safety of using IO-alone as a de-escalation strategy. We report outcome…
View article: P-365 Fertility preservation in patients with borderline ovarian tumors: safety and reproductive outcomes
P-365 Fertility preservation in patients with borderline ovarian tumors: safety and reproductive outcomes Open
Study question Do borderline ovarian tumors (BOT) patients, undergoing controlled ovarian stimulation (COS) face higher recurrence risks, and what are the associated reproductive outcomes? Summary answer Even in advanced-stage or bilateral…
View article: Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced or Recurrent Endometrial Cancer
Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced or Recurrent Endometrial Cancer Open
PURPOSE Selinexor inhibits exportin-1 (XPO1) resulting in nuclear accumulation of tumor suppressor proteins including p53 and has clinical activity in endometrial cancer (EC). The primary end point was to assess progression-free survival (…
View article: #554 Is there a prognostic value for the positive lymph-node ratio? An israeli gynecologic oncology group study
#554 Is there a prognostic value for the positive lymph-node ratio? An israeli gynecologic oncology group study Open
Introduction/Background Endometrial cancer is the fourth most common cancer in women in the developed countries. Although lymphadenectomy, particularly pelvic, is part of the surgical procedure for staging, its importance as a prognostic a…
View article: Development of an Enhanced Recovery After Surgery Surgical Safety Checklist Through a Modified Delphi Process
Development of an Enhanced Recovery After Surgery Surgical Safety Checklist Through a Modified Delphi Process Open
Importance Enhanced Recovery After Surgery (ERAS) guidelines and the World Health Organization Surgical Safety Checklist (SSC) are 2 well-established tools for optimizing patient outcomes perioperatively. Objective To integrate the 2 tools…
View article: Oncologic Outcomes of Surgically Treated Cervical Cancer with No Residual Disease on Hysterectomy Specimen: A 4C (Canadian Cervical Cancer Collaborative) Working Group Study
Oncologic Outcomes of Surgically Treated Cervical Cancer with No Residual Disease on Hysterectomy Specimen: A 4C (Canadian Cervical Cancer Collaborative) Working Group Study Open
Minimally invasive surgery for the treatment of macroscopic cervical cancer leads to worse oncologic outcomes than with open surgery. Preoperative conization may mitigate the risk of surgical approach. Our objective was to describe the onc…
View article: EP374/#164 A double-blind randomized trial comparing surgeon-administered transversus abdominis plane (TAP) block with placebo after midline laparotomy in gynecologic oncology
EP374/#164 A double-blind randomized trial comparing surgeon-administered transversus abdominis plane (TAP) block with placebo after midline laparotomy in gynecologic oncology Open
Objectives Surgeon-administered Transversus Abdominis Plane (TAP) block is a contemporary approach to providing postoperative analgesia. We evaluated its efficacy in a double-blind, randomized, placebo-controlled trial, hypothesizing that …
View article: 2022-RA-1165-ESGO Feasibility and safety of inguinofemoral sentinel lymph node biopsy for previously excised vulvar cancer
2022-RA-1165-ESGO Feasibility and safety of inguinofemoral sentinel lymph node biopsy for previously excised vulvar cancer Open
Introduction/Background Performing inguinofemoral sentinel lymph node biopsy (IFSLNB) for vulvar cancer following a previous vulvar excision, often referred to as 'scar injection,' is currently debated. Our study aimed to assess the feasib…
View article: Does sentinel lymph node biopsy in endometrial cancer surgery have an impact on the rate of adjuvant post operative pelvic radiation? An Israeli Gynecologic Oncology Group Study
Does sentinel lymph node biopsy in endometrial cancer surgery have an impact on the rate of adjuvant post operative pelvic radiation? An Israeli Gynecologic Oncology Group Study Open
Endometrial cancer patients undergoing lymph node assessment by sentinel lymph node biopsy, receive less pelvic radiotherapy.
View article: OP008/#194 P53ABN molecular subtype encompasses a morphologically diverse subset of endometrial cancers and identifies therapeutic opportunities to improve outcomes
OP008/#194 P53ABN molecular subtype encompasses a morphologically diverse subset of endometrial cancers and identifies therapeutic opportunities to improve outcomes Open
Objectives Molecular classification of endometrial cancer (EC) has important prognostic and therapeutic implications. p53abn EC represent the most aggressive molecular subtype, and recent data has shown a survival benefit from chemotherapy…
View article: OP015/#492 Further stratification of no specific molecular profile (NSMP/P53WT) endometrial carcinomas to refine prognosis and identify therapeutic opportunities
OP015/#492 Further stratification of no specific molecular profile (NSMP/P53WT) endometrial carcinomas to refine prognosis and identify therapeutic opportunities Open
Objectives Molecular classification identifies >50% of endometrial cancers (ECs) as having 'no specific molecular profile/NSMP'; without mismatch repair deficiency, p53 IHC abnormalities, or pathogenic POLE mutations. Clinical presentation…
View article: O006/#340 Minimally invasive surgery in advanced endometrial carcinoma is associated with an increased risk for local recurrence
O006/#340 Minimally invasive surgery in advanced endometrial carcinoma is associated with an increased risk for local recurrence Open
Objectives To compare oncological outcomes of women with stage II -IIIc endometrial cancer (EC) who underwent minimally invasive surgery (MIS) versus laparotomy. Methods A retrospective cohort study in an academic multi-center setting. Con…
View article: EPV097/#140 Application of a machine learning algorithm to identify predictors of recurrence and recurrence free survival in high grade endometrial cancer
EPV097/#140 Application of a machine learning algorithm to identify predictors of recurrence and recurrence free survival in high grade endometrial cancer Open
Objectives To train various machine learning algorithms to predict recurrence and recurrence-free survival (RFS) in high-grade endometrial cancer (HGEC) Methods Data was retrospectively collected across 8 Canadian centers including 1237 pa…
View article: EPV132/#552 The prognostic impact of lower uterine segment involvement in women with low-risk endometrial carcinoma: a multicenter study
EPV132/#552 The prognostic impact of lower uterine segment involvement in women with low-risk endometrial carcinoma: a multicenter study Open
Objectives To study whether lower uterine segment involvement (LUSI) correlates with oncological outcomes in women with stage IA endometrial carcinoma with low risk features. Methods We performed a retrospective multi-center cohort study o…
View article: EPV133/#555 Minimally invasive approach in endometrial cancer with lower uterine segment involvement in ≥ stage ii: is it safe?
EPV133/#555 Minimally invasive approach in endometrial cancer with lower uterine segment involvement in ≥ stage ii: is it safe? Open
Objectives To compare survival outcomes between women with stages II-IV endometrial carcinoma (EC) with lower uterine segment involvement (LUSI), staged by minimally invasive surgery (MIS) and those staged by laparotomy. Methods A retrospe…
View article: EPV063/#357 The impact of surgical approach in cases with no residual disease on hysterectomy specimen: a 4C (Canadian cervical cancer collaborative) working group study
EPV063/#357 The impact of surgical approach in cases with no residual disease on hysterectomy specimen: a 4C (Canadian cervical cancer collaborative) working group study Open
Objectives The adverse effect of laparoscopic/robotic surgery in cervical cancer has been established, however the exact patient population that this applies to has not been fully elucidated. Our objective was to characterize the impact of…
View article: EPV062/#354 Comparison of outcomes between abdominal, minimally invasive and combined vaginal- laparoscopic hysterectomy in patients with stage IAI/IA2 cervical cancer: 4C (Canadian cervical cancer collaborative) study
EPV062/#354 Comparison of outcomes between abdominal, minimally invasive and combined vaginal- laparoscopic hysterectomy in patients with stage IAI/IA2 cervical cancer: 4C (Canadian cervical cancer collaborative) study Open
Objectives Although minimally invasive(MIS) radical hysterectomy has been associated with worse survival compared to abdominal hysterectomy(AH), only 8% of patients in the LACC trial had microinvasive disease(Stage IA1/IA2). We sought to d…
View article: OP012/#257 Minimally invasive surgery is associated with an increased risk for local recurrence in high-grade endometrial carcinoma
OP012/#257 Minimally invasive surgery is associated with an increased risk for local recurrence in high-grade endometrial carcinoma Open
Objectives To compare oncological outcomes of women with high-grade endometrial carcinoma (HGEC) who underwent surgery by minimally invasive surgery (MIS) versus laparotomy. Methods A retrospective cohort study performed in an academic mul…
View article: EPV136/#605 Metformin use among diabetic women and endometrial cancer survival: an Israeli gynecologic oncology group study
EPV136/#605 Metformin use among diabetic women and endometrial cancer survival: an Israeli gynecologic oncology group study Open
Objectives Diabetes mellitus is a risk factor for the development of endometrial hyperplasia and endometrial carcinoma (EC). We aimed to evaluate the association between metformin use and oncologic outcome in diabetic women with EC. Method…
View article: OP005/#352 Safety of vaginal hysterectomy for cervical cancer: a multicenter cohort study on behalf of the 4C (Canadian cervical cancer collaborative) working group
OP005/#352 Safety of vaginal hysterectomy for cervical cancer: a multicenter cohort study on behalf of the 4C (Canadian cervical cancer collaborative) working group Open
Objectives Inferior outcomes of minimally invasive surgery (MIS) in cervical cancer may be attributable to exposure of peritoneum to tumor at colpotomy. Vaginal surgery may minimize surgical morbidity while avoiding dissemination. We sough…
View article: OP020/#524 Heath care resource and cost implications of integration of molecular classification in the management of endometrial cancer
OP020/#524 Heath care resource and cost implications of integration of molecular classification in the management of endometrial cancer Open
Objectives Increasing incidence and morbidity of endometrial cancer (EC) has resulted in high systemic cost burdens associated with management. Molecular classification is now being integrated into routine pathologic reporting, providing o…
View article: EPV131/#545 Lower uterine segment involvement in high-grade endometrial carcinoma is not independently associated with adverse oncological outcome
EPV131/#545 Lower uterine segment involvement in high-grade endometrial carcinoma is not independently associated with adverse oncological outcome Open
Objectives To evaluate the association of lower uterine segment involvement (LUSI) in high-grade endometrial cancer (HGEC) with oncological outcome. Methods We performed a retrospective multi-center cohort study of consecutive women with H…
View article: Disparities in the survival of endometrial cancer patients in a public healthcare system: A population-based cohort study.
Disparities in the survival of endometrial cancer patients in a public healthcare system: A population-based cohort study. Open
Objective: Social determinants of health (SDH) have been shown to correlate with adverse cancer outcomes. It is unclear if their impact goes beyond behavioral risk or healthcare access. We aimed to evaluate the association of SDH with endo…
View article: 4 Refining pathologic interpretation of endometrial carcinomas: lessons learned from a nationwide study in a new era of molecular classification
4 Refining pathologic interpretation of endometrial carcinomas: lessons learned from a nationwide study in a new era of molecular classification Open
Objectives Molecular classification of endometrial carcinoma (EC) enables consistent classification of tumours and provides valuable prognostic and predictive information. Herein we describe molecular subtype distribution and histomorpholo…