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Targeting Liver X Receptors in Cancer Drug Discovery Open

Asitha Premaratne, Abhinav Bagchi, Shinjini Basu, Jan-Ακε Gustafsson, Chin‐Yo Lin · 2024

Biology

Liver X receptors (LXRs) are members of the nuclear receptor superfamily of ligand-dependent transcription factors. LXRα is predominantly expressed in metabolic tissues, whereas LXRβ is ubiquitously expressed. Upon ligand binding, they reg…

Liver X Receptor Ligand GAC0001E5 Downregulates Antioxidant Capacity and ERBB2/HER2 Expression in HER2-Positive Breast Cancer Cells Open

Asitha Premaratne, Shinjini Basu, Abhinav Bagchi, Tianyi Zhou, Qin Feng , et al. · 2024

Chemistry Biology Medicine

The HER2-positive subtype accounts for approximately one-fifth of all breast cancers. Insensitivity and development of acquired resistance to targeted therapies in some patients contribute to their poor prognosis. HER2 overexpression is as…

Figure S2 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

IHC results for p16 and Mcm7.

Figure S1 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

H&E images of cancer and epithelium.

Figure S2 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

IHC results for p16 and Mcm7.

Table S2 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology Computer science

IHC conditions and information for antibodies and chemicals.

Figure S3 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

Cancer size data from E6/E7 mice.

Table S1 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

Description of mouse strains.

Table S1 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

Description of mouse strains.

Table S2 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

IHC conditions and information for antibodies and chemicals.

Supplementary Information from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

Supplemental materials and methods, supplemental figure legends

Figure S3 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

Cancer size data from E6/E7 mice.

Data from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Biology Medicine

Tumor-suppressor genes (TSG) are often deleted or transcriptionally suppressed in cancer. PGR codes for progesterone receptor (PR), a transcription factor whose function depends on its ligand. Although PR expression is often undetectable i…

Data from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Biology Medicine

Tumor-suppressor genes (TSG) are often deleted or transcriptionally suppressed in cancer. PGR codes for progesterone receptor (PR), a transcription factor whose function depends on its ligand. Although PR expression is often undetectable i…

Figure S1 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

H&E images of cancer and epithelium.

Figure S4 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

ESR1 expression levels and CNV data.

Figure S4 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

ESR1 expression levels and CNV data.

Supplementary Information from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer Open

Yuri Park, Seunghan Baik, Charles P. Ho, Chin‐Yo Lin, Sang‐Hyuk Chung · 2023

Medicine Biology

Supplemental materials and methods, supplemental figure legends

Supplementary Tables 1-3 from Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome Open

Jonna Frasor, Edmund C. Chang, Barry S. Komm, Chin‐Yo Lin, Vinsensius B. Vega , et al. · 2023

Medicine Biology Mathematics

Supplementary Tables 1-3 from Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome

Data from Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome Open

Jonna Frasor, Edmund C. Chang, Barry S. Komm, Chin‐Yo Lin, Vinsensius B. Vega , et al. · 2023

Biology Medicine

The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatory actions of estrogen, although tamoxifen c…

Supplementary Table 1 from Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer Open

Jonna Frasor, Aisha Weaver, Madhumita Pradhan, Yang Dai, Lance D. Miller , et al. · 2023

Medicine Computer science

Supplementary Table 1 from Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer

Data from Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome Open

Jonna Frasor, Edmund C. Chang, Barry S. Komm, Chin‐Yo Lin, Vinsensius B. Vega , et al. · 2023

Biology Medicine

The beneficial effect of the selective estrogen receptor (ER) modulator tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatory actions of estrogen, although tamoxifen c…

Data from Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer Open

Jonna Frasor, Aisha Weaver, Madhumita Pradhan, Yang Dai, Lance D. Miller , et al. · 2023

Medicine

Estrogen receptors (ER) and nuclear factor-κB (NF-κB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, we have recently found that ER and NF-κB can also …

Data from Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer Open

Jonna Frasor, Aisha Weaver, Madhumita Pradhan, Yang Dai, Lance D. Miller , et al. · 2023

Chemistry Biology Medicine

Estrogen receptors (ER) and nuclear factor-κB (NF-κB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, we have recently found that ER and NF-κB can also …

Supplementary Tables 1-3 from Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome Open

Jonna Frasor, Edmund C. Chang, Barry S. Komm, Chin‐Yo Lin, Vinsensius B. Vega , et al. · 2023

Biology Medicine Mathematics

Supplementary Tables 1-3 from Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome

Supplementary Table 1 from Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer Open

Jonna Frasor, Aisha Weaver, Madhumita Pradhan, Yang Dai, Lance D. Miller , et al. · 2023

Medicine Computer science

Supplementary Table 1 from Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer

Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells Open

Asitha Premaratne, Charles Ho, Shinjini Basu, Ashfia Fatima Khan, Tasneem Bawa‐Khalfe , et al. · 2023

Chemistry Biology Medicine

Liver X receptors (LXRs) are members of the nuclear receptor family of ligand-dependent transcription factors which regulate the expression of lipid and cholesterol metabolism genes. Moreover, LXRs and their ligands have been shown to inhi…

A Novel Liver X Receptor Inverse Agonist Impairs Cholesterol and Phospholipid Metabolism and Induces Apoptosis and Necroptosis in Pancreatic Ductal Adenocarcinoma Cells Open

Scott Widmann, Shivangi Srivastava, Chin‐Yo Lin · 2023

Biology

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high mortality rate and few effective treatments. A growing area of cancer therapeutics seeks to exploit the metabolic dysregulation of cancer cells, such as glucose, …

Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein Open

Seoung-Ae Lee, Charles Ho, Madison Troxler, Chin‐Yo Lin, Sang‐Hyuk Chung · 2021

Biology Medicine

Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance…

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