Lin Grimm
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Epigenomics and transcriptomics profiles of developing zebrafish heart cells Open
cis -Regulatory elements (cREs) are essential for the spatio-temporal control of gene expression during development and disease. However, cRE activity is highly dependent on cell and tissue type. The developing heart is composed of several…
Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence Open
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic stem and progenitor cells (HSPCs) arise from ventral aortic endothelium in all vertebrate animals studied. Work in ze…
View article: Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development Open
During development, the lymphatic vasculature forms as a second network derived chiefly from blood vessels. The transdifferentiation of embryonic venous endothelial cells (VECs) into lymphatic endothelial cells (LECs) is a key step in this…
Plexin D1 negatively regulates zebrafish lymphatic development Open
Lymphangiogenesis is a dynamic process that involves the directed migration of lymphatic endothelial cells (LECs) to form lymphatic vessels. The molecular mechanisms that underpin lymphatic vessel patterning are not fully elucidated and, t…
View article: Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development
Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development Open
During development, the lymphatic vasculature forms as a second, new vascular network derived from blood vessels. The transdifferentiation of embryonic venous endothelial cells (VECs) into lymphatic endothelial cells (LECs) is the first st…
Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk Open
Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway and effectors Yap and T…