Dawei Li
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View article: Systems pharmacology approaches decipher the anti-cancer efficacy of ethnopharmacological agents in hepatocellular carcinoma
Systems pharmacology approaches decipher the anti-cancer efficacy of ethnopharmacological agents in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) poses a significant global health burden with limited therapeutic efficacy. Chinese herbal medicines (CHMs) offer multi-target potential, yet their systematic screening and mechanistic elucidation remain chal…
View article: Who's Your Judge? On the Detectability of LLM-Generated Judgments
Who's Your Judge? On the Detectability of LLM-Generated Judgments Open
Large Language Model (LLM)-based judgments leverage powerful LLMs to efficiently evaluate candidate content and provide judgment scores. However, the inherent biases and vulnerabilities of LLM-generated judgments raise concerns, underscori…
View article: The MC4-La1 cleavage module restricts plant virus infection by integrating R-motif–mediated defense mRNA translation
The MC4-La1 cleavage module restricts plant virus infection by integrating R-motif–mediated defense mRNA translation Open
The plant cysteine protease metacaspases are structural homologs of animal caspases and play pivotal roles under biotic and abiotic stresses. However, whether metacaspases and purine-rich element (R-motif)–mediated defense messenger RNA tr…
View article: RING‐Between‐RING‐Type E3 Ligase Ariadne‐Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein
RING‐Between‐RING‐Type E3 Ligase Ariadne‐Like Protein 8 Negatively Regulates Plant Virus Infection by Targeting a Viral Movement Protein Open
The ubiquitin–proteasome system is a highly conserved machinery that plays a crucial role in plant defense against viruses. However, the number of E3 ligases targeting viral proteins remains limited. Although RING‐between‐RING (RBR)‐type E…
View article: Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancer
Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancer Open
View article: Advances in understanding multifunctionality of Barley stripe mosaic virus γb protein
Advances in understanding multifunctionality of Barley stripe mosaic virus γb protein Open
Plant viruses usually encode versatile but limited number of proteins to reshape the cellular microenvironment, suppress or co-opt host pathways and proteins for their own benefit. Barley stripe mosaic virus (BSMV, Hordeivirus hordei ) is …
View article: Model Editing as a Double-Edged Sword: Steering Agent Ethical Behavior Toward Beneficence or Harm
Model Editing as a Double-Edged Sword: Steering Agent Ethical Behavior Toward Beneficence or Harm Open
Agents based on Large Language Models (LLMs) have demonstrated strong capabilities across a wide range of tasks. However, deploying LLM-based agents in high-stakes domains comes with significant safety and ethical risks. Unethical behavior…
View article: A phosphorylation-driven ubiquitination switch fine-tunes Alfin-like 7–induced ROS signaling in plant immunity
A phosphorylation-driven ubiquitination switch fine-tunes Alfin-like 7–induced ROS signaling in plant immunity Open
Maintaining reactive oxygen species (ROS) homeostasis is essential for balancing growth-defense trade-offs in plants. Although the transcription factors (TFs) that regulate ROS production and scavenging genes have been studied, the regulat…
View article: Replication Organelles of Plant Positive-Strand RNA Viruses: A Boost in Knowledge Following New Imaging Approaches
Replication Organelles of Plant Positive-Strand RNA Viruses: A Boost in Knowledge Following New Imaging Approaches Open
As obligate intracellular parasites, viruses depend entirely on host cells for propagation, with replication being the central process in establishing their infections. Upon entry into host cells, positive-strand RNA viruses induce rearran…
View article: Comparison of oxycodone hydrochloride and flurbiprofen axetil on analgesia in mechanically ventilated patients with respiratory failure in a multicenter study
Comparison of oxycodone hydrochloride and flurbiprofen axetil on analgesia in mechanically ventilated patients with respiratory failure in a multicenter study Open
The design of this study is to compare the effectiveness of two analgesic drugs in the intervention of pain events for patients on mechanical ventilation. 414 patients from three hospitals with respiratory failure requiring mechanical vent…
View article: Effect of intravenous oxycodone hydrochloride versus flurbiprofen axetil on analgesia in patients with respiratory failure requiring mechanical ventilation: a multicenter randomized controlled study Running title: The effect of intravenous oxycodone hydrochloride versus flurbiprofen axetil on analgesia
Effect of intravenous oxycodone hydrochloride versus flurbiprofen axetil on analgesia in patients with respiratory failure requiring mechanical ventilation: a multicenter randomized controlled study Running title: The effect of intravenous oxycodone hydrochloride versus flurbiprofen axetil on analgesia Open
Trial design The design of this study is to compare the effectiveness of two analgesic drugs in the intervention of pain events for patients on mechanical ventilation. Methods 414 patients from three hospitals with respiratory failure requ…
View article: Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs
Triterpenoids from Ganoderma lucidum inhibit cytochrome P450 enzymes interfering with the metabolic process of specific clinical drugs Open
Background Ganoderma lucidum ( G. lucidum ), which possesses various biological effects, has been widely used as traditional medicine and functional food in Asian countries, especially China. In consideration of its various biological effe…
View article: Fluence-to-dose conversion coefficients in a voxel rat model for external neutron irradiation
Fluence-to-dose conversion coefficients in a voxel rat model for external neutron irradiation Open
Fluence-to-dose conversion coefficients based on a developed rat model have been calculated for neutrons with energies <20 MeV using Monte Carlo N-particle code (MCNP), for the purpose of neutron radiation effect evaluation. The calculation…
View article: DEAD‐box RNA helicase RH20 positively regulates RNAi‐based antiviral immunity in plants by associating with SGS3/RDR6 bodies
DEAD‐box RNA helicase RH20 positively regulates RNAi‐based antiviral immunity in plants by associating with SGS3/RDR6 bodies Open
Summary RNA silencing plays a crucial role in defending against viral infections in diverse eukaryotic hosts. Despite extensive studies on core components of the antiviral RNAi pathway such as DCLs, AGOs and RDRs proteins, host factors inv…
View article: Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions
Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions Open
Antibodies perform both neutralizing and non-neutralizing effector functions that protect against certain pathogen-induced diseases. A human antibody directed at the SARS-CoV-2 Spike N-terminal domain (NTD), DH1052, was recently shown to b…
View article: On the symmetric transformation with geometric constraints
On the symmetric transformation with geometric constraints Open
Coordinate transformation is a fundamental issue in the related studies of measurement. However, existing methodologies often need to pay more attention to the available spatial information, leading to suboptimal results. This paper addres…
View article: Zn2+-dependent association of cysteine-rich protein with virion orchestrates morphogenesis of rod-shaped viruses
Zn2+-dependent association of cysteine-rich protein with virion orchestrates morphogenesis of rod-shaped viruses Open
The majority of rod-shaped and some filamentous plant viruses encode a cysteine-rich protein (CRP) that functions in viral virulence; however, the roles of these CRPs in viral infection remain largely unknown. Here, we used barley stripe m…
View article: Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis
Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis Open
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cance…
View article: Plant virology in the 21st century in China: Recent advances and future directions
Plant virology in the 21st century in China: Recent advances and future directions Open
Plant viruses are a group of intracellular pathogens that persistently threaten global food security. Significant advances in plant virology have been achieved by Chinese scientists over the last 20 years, including basic research and tech…
View article: Factors influencing the degree of disability in patients with neuromyelitis optica spectrum disorders
Factors influencing the degree of disability in patients with neuromyelitis optica spectrum disorders Open
View article: A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors
A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors Open
View article: DiffuseIR:Diffusion Models For Isotropic Reconstruction of 3D Microscopic Images
DiffuseIR:Diffusion Models For Isotropic Reconstruction of 3D Microscopic Images Open
Three-dimensional microscopy is often limited by anisotropic spatial resolution, resulting in lower axial resolution than lateral resolution. Current State-of-The-Art (SoTA) isotropic reconstruction methods utilizing deep neural networks c…
View article: RETICULON-LIKE PROTEIN B2 is a proviral factor co-opted for the biogenesis of viral replication organelles in plants
RETICULON-LIKE PROTEIN B2 is a proviral factor co-opted for the biogenesis of viral replication organelles in plants Open
Endomembrane remodeling to form a viral replication complex (VRC) is crucial for a virus to establish infection in a host. Although the composition and function of VRCs have been intensively studied, host factors involved in the assembly o…
View article: Skeletal dosimetry in a microCT image-based rat model for external photon irradiation
Skeletal dosimetry in a microCT image-based rat model for external photon irradiation Open
Human skeletal dosimetry has experienced great developments in radiation protection in recent years by using the heterogeneous skeletal model. While for the rats experimentally used in radiation medicine, the investigation on skeletal dosi…
View article: Data from Digital Transcript Profile Analysis with aRNA-LongSAGE Validates FERMT1 As a Potential Novel Prognostic Marker for Colon Cancer
Data from Digital Transcript Profile Analysis with aRNA-LongSAGE Validates FERMT1 As a Potential Novel Prognostic Marker for Colon Cancer Open
Purpose: To use gene transcript profiling to identify cancer-associated gene expression.Experimental Design: Methods included (i) marker discovery using laser capture microdissection (LCM)-assisted specimen preparation and an…
View article: Data from Digital Transcript Profile Analysis with aRNA-LongSAGE Validates FERMT1 As a Potential Novel Prognostic Marker for Colon Cancer
Data from Digital Transcript Profile Analysis with aRNA-LongSAGE Validates FERMT1 As a Potential Novel Prognostic Marker for Colon Cancer Open
Purpose: To use gene transcript profiling to identify cancer-associated gene expression.Experimental Design: Methods included (i) marker discovery using laser capture microdissection (LCM)-assisted specimen preparation and an…
View article: Gene signature and prediction model of the mitophagy-associated immune microenvironment in renal ischemia-reperfusion injury
Gene signature and prediction model of the mitophagy-associated immune microenvironment in renal ischemia-reperfusion injury Open
Background Renal ischemia-reperfusion injury (IRI) is an inevitable occurrence during kidney transplantation. Mitophagy, ferroptosis, and the associated immune microenvironment (IME) have been shown to play important roles in renal IRI. Ho…
View article: Effect of respiratory training on respiratory failure secondary to unilateral phrenic nerve injury: A case report
Effect of respiratory training on respiratory failure secondary to unilateral phrenic nerve injury: A case report Open
Introduction: Diaphragm is one of the most important respiratory muscles dominated by the phrenic nerve. Phrenic nerve injury would induce a series of clinical symptoms, including respiratory failure. Respiratory training could assist in r…
View article: The MAPK-Alfin-like 7 module negatively regulates ROS scavenging genes to promote NLR-mediated immunity
The MAPK-Alfin-like 7 module negatively regulates ROS scavenging genes to promote NLR-mediated immunity Open
Nucleotide-binding leucine-rich repeat (NLR) receptor-mediated immunity includes rapid production of reactive oxygen species (ROS) and transcriptional reprogramming, which is controlled by transcription factors (TFs). Although some TFs hav…
View article: Supplementary Material for: Correlation of Neuroendocrine Differentiation with A Distinctively Suppressive Immune Microenvironment in Gastric Cancer
Supplementary Material for: Correlation of Neuroendocrine Differentiation with A Distinctively Suppressive Immune Microenvironment in Gastric Cancer Open
Introduction Neuroendocrine neoplasms (NENs) harbored significantly suppressive tumor immune microenvironments (TIMEs). However, the immunological effects of neuroendocrine differentiation (NED) on non-NE neoplasms, such as gastric cancer …