Na‐Sheng Lin
YOU?
Author Swipe
View article: Nucleolar fibrillarin methyltransferase regulates systemic trafficking of a plant virus satellite RNA
Nucleolar fibrillarin methyltransferase regulates systemic trafficking of a plant virus satellite RNA Open
RNA trafficking is crucial in almost every phase of plant development. Fibrillarin (FIB), a highly conserved nucleolar protein with methyltransferase (MTase) activity, functions in methylation and rRNA processing and facilitates the transp…
View article: Dual‐Layer Transcriptional‐Protein Regulation by <scp>HvAP2</scp> ‐12 Represses <scp>HvAP2</scp> ‐18 Activity to Fine‐Tune Barley Starch Synthesis
Dual‐Layer Transcriptional‐Protein Regulation by <span>HvAP2</span> ‐12 Represses <span>HvAP2</span> ‐18 Activity to Fine‐Tune Barley Starch Synthesis Open
Starch content and composition are key factors determining yield and quality of barley, but the molecular mechanisms regulating barley starch synthesis remain unclear. In this study, we identified an APETALA2/Ethylene‐Responsive factor (AP…
View article: Virus-induced upregulation of mitochondrial metabolism modulates cytosolic redox balance and defense responses
Virus-induced upregulation of mitochondrial metabolism modulates cytosolic redox balance and defense responses Open
Plants possess a remarkable capacity to reprogram their metabolism in response to pathogen attacks. However, the mechanisms by which metabolic reprogramming modulates defense signaling remain poorly understood. In this study, we leverage a…
View article: CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation
CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation Open
Background Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory infections in children, yet biomarkers for assessing disease severity remain limited. Herein, we investigated the differential expression biomarker…
View article: <scp>NbHDR</scp> , A Host Protein Involved in the <scp>MEP</scp> Pathway, Interacts With <i>Bamboo Mosaic Virus</i> Replicase and Enhances Viral Accumulation
<span>NbHDR</span> , A Host Protein Involved in the <span>MEP</span> Pathway, Interacts With <i>Bamboo Mosaic Virus</i> Replicase and Enhances Viral Accumulation Open
Plant viruses, as obligate parasites, depend on host cellular machinery for various processes essential to their life cycle, making the investigation of these interactions fundamentally important. Bamboo mosaic virus (BaMV), a positive‐str…
View article: Proviral insights of glycolytic enolase in <i>Bamboo mosaic virus</i> replication associated with chloroplasts and mitochondria
Proviral insights of glycolytic enolase in <i>Bamboo mosaic virus</i> replication associated with chloroplasts and mitochondria Open
Diverse single-stranded RNA viruses employ different host cellular organelles or membrane systems to compartmentalize their replication intermediates and proviral factors, ensuring robust replication. Replication of Bamboo mosaic virus (Ba…
View article: Andrographolide induces testicular damage via triggering oxidative stress and iron overload by disrupting β-TrCP-mediated ATF4 ubiquitination in Sertoli cells
Andrographolide induces testicular damage via triggering oxidative stress and iron overload by disrupting β-TrCP-mediated ATF4 ubiquitination in Sertoli cells Open
View article: Revelation of Core Promoter Elements and Bidirectional Regulation of Geminivirus Genes in Escherichia coli
Revelation of Core Promoter Elements and Bidirectional Regulation of Geminivirus Genes in Escherichia coli Open
View article: Ethylene-Responsive Factor Hverf72 Regulates Starch Synthesis and B-Type Starch Granules Initiation in Barley
Ethylene-Responsive Factor Hverf72 Regulates Starch Synthesis and B-Type Starch Granules Initiation in Barley Open
View article: Development of a tag-free plant-made interferon gamma production system with improved therapeutic efficacy against viruses
Development of a tag-free plant-made interferon gamma production system with improved therapeutic efficacy against viruses Open
Plants offer a promising platform for cost-effective production of biologically active therapeutic glycoproteins. In previous studies, we have developed a plant expression system based on Bamboo mosaic virus (BaMV) by incorporating secreto…
View article: Importin α2 participates in <scp>RNA</scp> interference against bamboo mosaic virus accumulation in <i>Nicotiana benthamiana</i> via <scp>NbAGO10a</scp> ‐mediated small <scp>RNA</scp> clearance
Importin α2 participates in <span>RNA</span> interference against bamboo mosaic virus accumulation in <i>Nicotiana benthamiana</i> via <span>NbAGO10a</span> ‐mediated small <span>RNA</span> clearance Open
Karyopherins, the nucleocytoplasmic transporters, participate in multiple RNA silencing stages by transporting associated proteins into the nucleus. Importin α is a member of karyopherins and has been reported to facilitate virus infection…
View article: Research progress on free fatty acid receptors and bronchial asthma
Research progress on free fatty acid receptors and bronchial asthma Open
Bronchial asthma is a chronic respiratory disease characterized by reversible airflow limitation, including airway hyperresponsiveness, airway inflammation and airway remodeling. The clinical manifestations are recurrent tachypnea, wheezin…
View article: Trade-off between local replication and long-distance dissemination during experimental evolution of a satellite RNA
Trade-off between local replication and long-distance dissemination during experimental evolution of a satellite RNA Open
Satellite RNAs (satRNAs) are molecular parasites that depend on their non-homologous helper viruses (HVs) for essential biological functions. While there are multiple molecular and phylogenetic studies on satRNAs, there is no experimental …
View article: Argonaute 5-mediated antiviral defense and viral counter-defense in Nicotiana benthamiana
Argonaute 5-mediated antiviral defense and viral counter-defense in Nicotiana benthamiana Open
The argonaute (AGO) family proteins play a crucial role in preventing viral invasions through the plant antiviral RNA silencing pathway, with distinct AGO proteins recruited for specific antiviral mechanisms. Our previous study revealed th…
View article: A viral movement protein co-opts endoplasmic reticulum luminal-binding protein and calreticulin to promote intracellular movement
A viral movement protein co-opts endoplasmic reticulum luminal-binding protein and calreticulin to promote intracellular movement Open
Intracellular movement is an important step for the initial spread of virus in plants during infection. This process requires virus-encoded movement proteins (MPs) and their interaction with host factors. Despite the large number of known …
View article: Characterization of Virus-Inducible Orchid Argonaute 5b Promoter and Its Functional Characterization in Nicotiana benthamiana during Virus Infection
Characterization of Virus-Inducible Orchid Argonaute 5b Promoter and Its Functional Characterization in Nicotiana benthamiana during Virus Infection Open
Plant ARGONAUTES (AGOs) play a significant role in the defense against viral infection. Previously, we have demonstrated that AGO5s encoded in Phalaenopsis aphrodite subsp. formosana (PaAGO5s) took an indispensable part in defense against …
View article: NbNAC42 and NbZFP3 Transcription Factors Regulate the Virus Inducible NbAGO5 Promoter in Nicotiana benthamiana
NbNAC42 and NbZFP3 Transcription Factors Regulate the Virus Inducible NbAGO5 Promoter in Nicotiana benthamiana Open
Plant argonautes (AGOs) play important roles in the defense responses against viruses. The expression of Nicotiana benthamiana AGO5 gene ( NbAGO5 ) is highly induced by Bamboo mosaic virus (BaMV) infection; however, the underlying mechanis…
View article: Dynamics of mitochondrial nucleoid proteins involved in development of cotyledon mitochondria during mung bean seed germination
Dynamics of mitochondrial nucleoid proteins involved in development of cotyledon mitochondria during mung bean seed germination Open
Mitochondrial DNA (mtDNA) protein complexes, called mitochondrial-nucleoids (mt-nucleoids), are dynamic and redistribute during mitochondria propagation and gene expression. These proteins involve in mtDNA replication, transcription, maint…
View article: First Report of Distinct Bamboo mosaic virus (BaMV) Isolates Infecting Bambusa funghomii in Vietnam and the Identification of a Highly Variable Region in the BaMV Genome
First Report of Distinct Bamboo mosaic virus (BaMV) Isolates Infecting Bambusa funghomii in Vietnam and the Identification of a Highly Variable Region in the BaMV Genome Open
New isolates of the Bamboo mosaic virus (BaMV) were identified in Bambusa funghomii bamboo in Vietnam. Sequence analyses revealed that the Vietnam isolates are distinct from all known BaMV strains, sharing the highest sequence identities (…
View article: Identification of Crucial Amino Acids in Begomovirus C4 Proteins Involved in the Modulation of the Severity of Leaf Curling Symptoms
Identification of Crucial Amino Acids in Begomovirus C4 Proteins Involved in the Modulation of the Severity of Leaf Curling Symptoms Open
Begomoviruses frequently inflict upward or downward leaf curling symptoms on infected plants, leading to severe economic damages. Knowledge of the underlying mechanism controlling the leaf curling severity may facilitate the development of…
View article: Re-examination of the APETALA2/Ethylene-Responsive Factor Gene Family in Barley (Hordeum vulgare L.) Indicates a Role in the Regulation of Starch Synthesis
Re-examination of the APETALA2/Ethylene-Responsive Factor Gene Family in Barley (Hordeum vulgare L.) Indicates a Role in the Regulation of Starch Synthesis Open
The APETALA2/Ethylene-Responsive factor ( AP2/ERF ) gene family is a large plant-specific transcription factor family, which plays important roles in regulating plant growth and development. A role in starch synthesis is among the multiple…
View article: Voltage-dependent anion channel proteins associate with dynamic<i>Bamboo mosaic virus</i>-induced complexes
Voltage-dependent anion channel proteins associate with dynamic<i>Bamboo mosaic virus</i>-induced complexes Open
Infection cycles of viruses are highly dependent on membrane-associated host factors. To uncover the infection cycle of Bamboo mosaic virus (BaMV) in detail, we purified the membrane-associated viral complexes from infected Nicotiana benth…
View article: Convenient Auto-Processing Vector Based on Bamboo Mosaic Virus for Presentation of Antigens Through Enzymatic Coupling
Convenient Auto-Processing Vector Based on Bamboo Mosaic Virus for Presentation of Antigens Through Enzymatic Coupling Open
We have developed a new binary epitope-presenting CVP platform based on bamboo mosaic virus (BaMV) by using the sortase A (SrtA)-mediated ligation technology. The reconstructed BaMV genome harbors two modifications: 1) a coat protein (CP) …
View article: MiR398-regulated antioxidants contribute to <i>Bamboo mosaic virus</i> accumulation and symptom manifestation
MiR398-regulated antioxidants contribute to <i>Bamboo mosaic virus</i> accumulation and symptom manifestation Open
Virus infections that cause mosaic or mottling in leaves commonly also induce increased levels of reactive oxygen species (ROS). However, how ROS contributes to symptoms is less well documented. Bamboo mosaic virus (BaMV) causes chlorotic …
View article: NbPsbO1 Interacts Specifically with the <i>Bamboo Mosaic Virus</i> (BaMV) Subgenomic RNA (sgRNA) Promoter and Is Required for Efficient BaMV sgRNA Transcription
NbPsbO1 Interacts Specifically with the <i>Bamboo Mosaic Virus</i> (BaMV) Subgenomic RNA (sgRNA) Promoter and Is Required for Efficient BaMV sgRNA Transcription Open
Production of subgenomic RNAs (sgRNAs) for efficient translation of downstream viral proteins is one of the major strategies adapted for viruses that contain a multicistronic RNA genome. Both viral genomic RNA (gRNA) replication and sgRNA …
View article: Exploring the Multifunctional Roles of Odontoglossum Ringspot Virus P126 in Facilitating Cymbidium Mosaic Virus Cell-to-Cell Movement during Mixed Infection
Exploring the Multifunctional Roles of Odontoglossum Ringspot Virus P126 in Facilitating Cymbidium Mosaic Virus Cell-to-Cell Movement during Mixed Infection Open
Synergistic interactions among viruses, hosts and/or transmission vectors during mixed infection can alter viral titers, symptom severity or host range. Viral suppressors of RNA silencing (VSRs) are considered one of such factors contribut…
View article: Genome-wide identification of bZIP transcription factor genes related to starch synthesis in barley (<i>Hordeum vulgare</i> L.)
Genome-wide identification of bZIP transcription factor genes related to starch synthesis in barley (<i>Hordeum vulgare</i> L.) Open
The basic leucine zipper (bZIP) family of genes encode transcription factors that play key roles in plant growth and development. In this study, a total of 92 HvbZIP genes were identified and compared with previous studies using recently r…
View article: Binding of microRNA-135a (miR-135a) to homeobox protein A10 (HOXA10) mRNA in a high-progesterone environment modulates the embryonic implantation factors beta3-integrin (ITGβ3) and empty spiracles homeobox-2 (EMX2)
Binding of microRNA-135a (miR-135a) to homeobox protein A10 (HOXA10) mRNA in a high-progesterone environment modulates the embryonic implantation factors beta3-integrin (ITGβ3) and empty spiracles homeobox-2 (EMX2) Open
In vitro, the trend in miR-135a expression (which first decreased and then increased) was in direct contrast to that of HOXA10 expression (which first increased and then decreased) as progesterone levels increased. The key fa…
View article: Stable Display of Artificially Long Foreign Antigens on Chimeric Bamboo mosaic virus Particles
Stable Display of Artificially Long Foreign Antigens on Chimeric Bamboo mosaic virus Particles Open
Plant viruses can be genetically modified to generate chimeric virus particles (CVPs) carrying heterologous peptides fused on the surface of coat protein (CP) subunits as vaccine candidates. However, some factors may be especially signific…
View article: Argonaute 5 family proteins play crucial roles in the defence against <i>Cymbidium</i><i>mosaic</i><i>virus</i> and <i>Odontoglossum</i><i>ringspot</i><i>virus</i> in <i>Phalaenopsis</i><i>aphrodite</i> subsp. <i>formosan</i><i>a</i>
Argonaute 5 family proteins play crucial roles in the defence against <i>Cymbidium</i><i>mosaic</i><i>virus</i> and <i>Odontoglossum</i><i>ringspot</i><i>virus</i> in <i>Phalaenopsis</i><i>aphrodite</i> subsp. <i>formosan</i><i>a</i> Open
The orchid industry faces severe threats from diseases caused by viruses. Argonaute proteins (AGOs) have been shown to be the major components in the antiviral defence systems through RNA silencing in many model plants. However, the roles …