Quan‐Lin Li
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View article: Feasibility and Safety of Endoscopic Full‐Thickness Resection for Gastric Submucosal Tumors With Extraluminal Growth
Feasibility and Safety of Endoscopic Full‐Thickness Resection for Gastric Submucosal Tumors With Extraluminal Growth Open
Background Although endoscopic resection is an accepted technique for gastric submucosal tumors (SMTs), extraluminal tumors remain a challenging procedure with limited data. This study aimed to evaluate the efficacy and safety of endoscopi…
View article: Hypoglycemic effect of W/O/W emulsion encapsulating Polygonatum sibiricum polysaccharides and saponins in a mouse model of T2DM
Hypoglycemic effect of W/O/W emulsion encapsulating Polygonatum sibiricum polysaccharides and saponins in a mouse model of T2DM Open
This study explores the hypoglycemic efficacy of W/O/W emulsion co-encapsulating Polygonatum sibiricum polysaccharides (PSP) and saponins (PSS). In streptozotocin/high-fat diet-induced type 2 diabetes mellitus (T2DM) mice, the encapsulated…
View article: The <scp>RING</scp> ‐finger <scp>E3</scp> ubiquitin ligase <scp>SlMIEL1</scp> interacts with <scp>SlNAC35</scp> to regulate <scp>JA</scp> biosynthesis and mediate saline‐alkali stress responses in tomato
The <span>RING</span> ‐finger <span>E3</span> ubiquitin ligase <span>SlMIEL1</span> interacts with <span>SlNAC35</span> to regulate <span>JA</span> biosynthesis and mediate saline‐alkali stress responses in tomato Open
SUMMARY Saline‐alkali stress, as a widely existing abiotic stress, severely restricts plant growth and development. NAC transcription factors play a key role in plants' adaptation to abiotic stresses such as low temperature, drought, and s…
View article: First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia Open
Background Idiopathic achalasia (IA) is characterised by the degeneration of neurons in the myenteric plexus leading to an irreversible impaired oesophageal function. Although immune-mediated mechanisms have been proposed, the underlying a…
View article: RuN: Residual Policy for Natural Humanoid Locomotion
RuN: Residual Policy for Natural Humanoid Locomotion Open
Enabling humanoid robots to achieve natural and dynamic locomotion across a wide range of speeds, including smooth transitions from walking to running, presents a significant challenge. Existing deep reinforcement learning methods typicall…
View article: Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer
Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer Open
Understanding the cellular origins and early evolutionary dynamics that drive the initiation of carcinogenesis is critical to advancing early detection and prevention strategies. By characterizing key molecular, cellular and niche events a…
View article: Sex-specific association of visceral and abdominal subcutaneous adipose tissue with gastroesophageal reflux disease: a large-scale perspective cohort study
Sex-specific association of visceral and abdominal subcutaneous adipose tissue with gastroesophageal reflux disease: a large-scale perspective cohort study Open
We observed positive associations between abdominal adipose components and GERD in both sexes, which were stronger in females than males. Our findings provide evidence that gender may be a factor to be considered in the risk assessment and…
View article: EndoFinder: Online Lesion Retrieval for Explainable Colorectal Polyp Diagnosis Leveraging Latent Scene Representations
EndoFinder: Online Lesion Retrieval for Explainable Colorectal Polyp Diagnosis Leveraging Latent Scene Representations Open
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, underscoring the importance of timely polyp detection and diagnosis. While deep learning models have improved optical-assisted diagnostics, they often demand exte…
View article: Feasibility and safety of endoscopic resection for duodenal gastrointestinal stromal tumors
Feasibility and safety of endoscopic resection for duodenal gastrointestinal stromal tumors Open
Endoscopic resection for duodenal gastrointestinal stromal tumors (GISTs) is still considered a great challenge with a high risk of complications. This study aimed to evaluate effectiveness and safety of endoscopic resection for duodenal G…
View article: Greenness and allergic rhinitis in children: the moderating and mediating effects of meteorological factors and air pollution
Greenness and allergic rhinitis in children: the moderating and mediating effects of meteorological factors and air pollution Open
Background Emerging evidence suggests that greenness may be beneficial to human health; however, the relationship between greenness exposure and childhood allergic rhinitis (AR) is inconsistent, and whether and how the link is moderated or…
View article: Predictors for Achieving Textbook outcomes after endoscopic resection of giant submucosal tumors in the esophagus and cardia
Predictors for Achieving Textbook outcomes after endoscopic resection of giant submucosal tumors in the esophagus and cardia Open
Background and Aims: Endoscopic resection for submucosal tumors (SMTs) in the esophagus and cardia is challenging with hazards of adverse events and the exploration of its achieving textbook outcome (TO) was unknown. We aim to investigate …
View article: Assessment of the public health risk of novel reassortant H3N3 avian influenza viruses that emerged in chickens
Assessment of the public health risk of novel reassortant H3N3 avian influenza viruses that emerged in chickens Open
Influenza A (H3N2) viruses are historically responsible for the 1968 Hong Kong flu pandemic. Since then, H3N2 has continued to circulate as a seasonal influenza virus in humans. Public health concerns were raised in 2022 when human infecti…
View article: GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing
GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing Open
ClinicalTrials.gov identifier: NCT05431621.
View article: Expert-AI Collaborative Training for Novice Endoscopists: A Path to Enhanced Efficiency
Expert-AI Collaborative Training for Novice Endoscopists: A Path to Enhanced Efficiency Open
Background: Esophagogastroduodenoscopy (EGD) is essential for diagnosing upper gastrointestinal disorders. Traditional training for novice endoscopists is often inefficient and inconsistent. This study evaluates the effectiveness of an AI-…
View article: Endo-CLIP: Progressive Self-Supervised Pre-training on Raw Colonoscopy Records
Endo-CLIP: Progressive Self-Supervised Pre-training on Raw Colonoscopy Records Open
Pre-training on image-text colonoscopy records offers substantial potential for improving endoscopic image analysis, but faces challenges including non-informative background images, complex medical terminology, and ambiguous multi-lesion …
View article: Computed tomography-based conventional imaging features and texture analysis characteristics of chemotherapy drug-related acute pancreatitis
Computed tomography-based conventional imaging features and texture analysis characteristics of chemotherapy drug-related acute pancreatitis Open
Purpose Chemotherapy drug-related acute pancreatitis (CDRAP) is a rare adverse event that poses significant challenges to clinicians. This study aimed to describe plain computed tomography (CT)- and contrast-enhanced computed tomography (C…
View article: Investigating Clinical Significance of 3D Single-hole Thoracoscopy Surgery for Mediastinal Tumor Resection With Artificial Pneumothorax
Investigating Clinical Significance of 3D Single-hole Thoracoscopy Surgery for Mediastinal Tumor Resection With Artificial Pneumothorax Open
AIM: This study aims to analyze and compare the clinical efficacy and safety between single-hole approach and two-hole video-assisted thoracoscopic surgery (VATS) for mediastinal tumor resection. METHODS: This study included 62 patients wh…
View article: The African swine fever virus MGF360-16R protein functions as a mitochondrial-dependent apoptosis inducer by competing with BAX to bind to the HSP60 protein
The African swine fever virus MGF360-16R protein functions as a mitochondrial-dependent apoptosis inducer by competing with BAX to bind to the HSP60 protein Open
Induction of cell apoptosis is a critical pathogenic feature of the African swine fever virus (ASFV), a devastating threat to the world pig industry, but the underlying mechanisms have remained unclear. Here, we report the genome-wide scre…
View article: Robust Polyp Detection and Diagnosis through Compositional Prompt-Guided Diffusion Models
Robust Polyp Detection and Diagnosis through Compositional Prompt-Guided Diffusion Models Open
Colorectal cancer (CRC) is a significant global health concern, and early detection through screening plays a critical role in reducing mortality. While deep learning models have shown promise in improving polyp detection, classification, …
View article: Scoring system supporting suture decision-making for duodenal submucosal tumors
Scoring system supporting suture decision-making for duodenal submucosal tumors Open
BACKGROUND In recent years, endoscopic resection (ER) has been employed for the excision of submucosal tumors (SMTs). Nonetheless, ER in the duodenum is linked to elevated risks of both immediate and delayed hemorrhagic complications and p…
View article: Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study
Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study Open
Background We aimed to investigate associations between three perinatal early-life factors and the risk of irritable bowel syndrome (IBS) in middle-aged and elderly people by using data from UK Biobank. Methods This is a population-based c…