Jiaqi Zhao
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View article: Engineering Immune Microenvironments for Organoid-on-a-Chip Systems
Engineering Immune Microenvironments for Organoid-on-a-Chip Systems Open
Organoid-on-a-chip technology synergizes the self-organizing capacity and cellular complexity of organoids with the precise microenvironmental control offered by organ-on-a-chip systems, significantly advancing the physiological relevance …
View article: Glial-derived neurotrophic factor promotes aberrant basal cell hyperplasia in nasal polyps
Glial-derived neurotrophic factor promotes aberrant basal cell hyperplasia in nasal polyps Open
GDNF drives aberrant epithelial remodeling in CRSwNP via MAPK/PI3K signaling, highlighting its therapeutic potential for refractory disease.
View article: Unlocking Hopeaphenol: A Potent Ally Against Cardiac Hypertrophy via AMPK Activation
Unlocking Hopeaphenol: A Potent Ally Against Cardiac Hypertrophy via AMPK Activation Open
Background: Abnormal mitochondrial energy metabolism is a key factor in the development and progression of cardiac hypertrophy. Hopeaphenol (HP), a tetramer of the natural polyphenol resveratrol, exhibits higher biological activity than re…
View article: Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism Open
Background: Post-myocardial infarction (MI) heart failure (HF) is characterized by myocardial energy metabolism disorder, with excessive glycolysis playing a key role in its progression. Silybin (SIL), a flavonoid derived from Silybum mari…
View article: Intermolecular Interaction Induced Synergistic Passivation toward Efficient and Stable 1.68 eV Bandgap Perovskite Solar Cells
Intermolecular Interaction Induced Synergistic Passivation toward Efficient and Stable 1.68 eV Bandgap Perovskite Solar Cells Open
The performance and stability of wide‐band‐gap (1.68 eV) perovskite solar cells (PSCs) are critically constrained by two main challenges: i) nonradiative recombination and ii) insufficient environmental stability. In this study, a chemical…
View article: Arg-Gly-Asp engineered mesenchymal stem cells as targeted nanotherapeutics against kidney fibrosis by modulating m6A
Arg-Gly-Asp engineered mesenchymal stem cells as targeted nanotherapeutics against kidney fibrosis by modulating m6A Open
Background The recent surge in research on extracellular vesicles has generated considerable interest in their clinical applications. Extracellular vesicles derived from mesenchymal stem cells (MSC-EV) have emerged as a promising cell-free…
View article: Xenia Effect on Nutritional and Flavor Components of ‘Jingbaili’ Pear
Xenia Effect on Nutritional and Flavor Components of ‘Jingbaili’ Pear Open
The ‘Jingbaili’ pear is a national geographical indication product of China, featuring an oblate shape and being rich in nutrients. But the quality of the ‘Jingbaili’ pear is unstable. Xenia can cause changes in the quality of pears, but t…
View article: Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma
Prognostic value and drug sensitivity of F‑box and leucine‑rich repeat protein 6 in glioma Open
Gliomas are highly malignant and invasive tumors lacking clear boundaries. Previous bioinformatics and experimental analyses have indicated that F-box and leucine-rich repeat protein 6 (FBXL6), a protein crucial for the cell cycle and tumo…
View article: Cationic anticancer peptide L-K6-modified and doxorubicin-loaded mesoporous silica nanoparticles reverse multidrug resistance of breast cancer
Cationic anticancer peptide L-K6-modified and doxorubicin-loaded mesoporous silica nanoparticles reverse multidrug resistance of breast cancer Open
Multidrug resistance (MDR) is the major challenge for chemotherapy of cancer and makes the treatment benefits unsustainable. To overcome this issue, nanotechnology has been introduced and various nanocarriers have been constructed to rever…
View article: Prognostic value and drug sensitivity of FBXL6 in glioma
Prognostic value and drug sensitivity of FBXL6 in glioma Open
Purpose Gliomas are highly malignant and invasive tumors that lack clear boundaries. Recent bioinformatics and experimental analyses have indicated that FBXL6, a protein crucial for the cell cycle and tumorigenesis, is highly expressed in …
View article: Brown tumor due to primary hyperparathyroidism in a familial case: a case report
Brown tumor due to primary hyperparathyroidism in a familial case: a case report Open
Background Primary hyperparathyroidism (PHPT) is an uncommon disorder characterised by hypercalcemia with an increased parathyroid hormone level. We reported a PHPT familial case with two subjects, a father and a daughter, and both of them…
View article: Nodular lymphoid hyperplasia, a rare case report
Nodular lymphoid hyperplasia, a rare case report Open
Background: A rare immune-deficient condition is known as nodular lymphoid hyperplasia (NLH). It is not known how common it is, but gene-molecular testing in conjunction with a medical history may definitively identify it. Case summary: A …
View article: Transcriptomic analysis provides insights into the abscisic acid mediates brassinosteroid-induced cold resistance of grapevine (Vitis vinifera L.)
Transcriptomic analysis provides insights into the abscisic acid mediates brassinosteroid-induced cold resistance of grapevine (Vitis vinifera L.) Open
The potential role of brassinosteroid (BR) and abscisic acid (ABA) against cold stress in plants separately has been made with much effort. However, the connection between BR and ABA in response to cold stress is less clear. Herein, the po…
View article: Quantitative Diagnosis Progress of Ultrasound Imaging Technology in Thyroid Diffuse Diseases
Quantitative Diagnosis Progress of Ultrasound Imaging Technology in Thyroid Diffuse Diseases Open
High-frequency ultrasound (HFUS), the imaging modality of choice for thyroid screening, is most commonly used in the study of diffuse thyroid disease (DTD) with Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). DTD can involve thyroid…
View article: Assessment of the statistical optimization strategies and clinical evaluation of an artificial intelligence-based automated diagnostic system for thyroid nodule screening
Assessment of the statistical optimization strategies and clinical evaluation of an artificial intelligence-based automated diagnostic system for thyroid nodule screening Open
Using our optimization strategy to achieve nodule-based diagnosis, the AI-SONIC Thyroid automated diagnostic system demonstrated an overall diagnostic accuracy equivalent to that of senior radiologists. Thus, it is expected that it can be …
View article: Nanoscale Contrast Agents for Ultrasound Imaging of Musculoskeletal System
Nanoscale Contrast Agents for Ultrasound Imaging of Musculoskeletal System Open
Musculoskeletal ultrasound (MSKUS) has been recognized as an important method for the evaluation of diseases of the musculoskeletal system, and contrast-enhanced ultrasound (CEUS) technology is becoming an important branch of it. The devel…
View article: Curcumin inhibits invasion and metastasis of human hepatoma cells through Bclaf1-mediated Wnt/β-catenin signalling
Curcumin inhibits invasion and metastasis of human hepatoma cells through Bclaf1-mediated Wnt/β-catenin signalling Open
Curcumin, a kind of natural compound extracted from the rhizome of Zingiberaceae such as turmeric, has many pharmacological effects such as anti-cancer effects. This study investigated the effect of curcumin on the invasion and metastasis …
View article: Curcumin induces mitochondrial apoptosis in human hepatoma cells through BCLAF1-mediated modulation of PI3K/AKT/GSK-3β signaling
Curcumin induces mitochondrial apoptosis in human hepatoma cells through BCLAF1-mediated modulation of PI3K/AKT/GSK-3β signaling Open
Curcumin is a yellow pigment extracted from the rhizome of turmeric, a traditional Chinese medicine. Here, we tested the hypothesis that curcumin-mediated downregulation of BCLAF1 triggers mitochondrial apoptosis in hepatoma cells by inhib…
View article: Quantitative assessment of changes in skeletal muscle injury by computer‐aided analysis based on two‐dimensional ultrasonography combined with contrast‐enhanced ultrasonography and estimated by a modified semi‐quantitative scoring system: An experimental study in a contusion model
Quantitative assessment of changes in skeletal muscle injury by computer‐aided analysis based on two‐dimensional ultrasonography combined with contrast‐enhanced ultrasonography and estimated by a modified semi‐quantitative scoring system: An experimental study in a contusion model Open
The aim of this study was to investigate the potential application of computer‐aided analysis in the quantitative assessment of changes in skeletal muscle injury in the rabbit contusion model. Forty healthy rabbits were randomly divided in…
View article: Curcumin induces Mitochondrial Apoptosis in Human Hepatoma Cells through BCLAF1-mediated Modulation of PI3K/AKT/GSK-3β Signaling
Curcumin induces Mitochondrial Apoptosis in Human Hepatoma Cells through BCLAF1-mediated Modulation of PI3K/AKT/GSK-3β Signaling Open
Curcumin is a yellow pigment extracted from the rhizome of turmeric, a traditional Chinese medicine. Here, we tested the hypothesis that curcumin-mediated downregulation of BCLAF1 triggers mitochondrial apoptosis in hepatoma cells by inhib…
View article: Incidental Ultrasound Findings of a Giant Retroperitoneal Schwannoma: A Case Study
Incidental Ultrasound Findings of a Giant Retroperitoneal Schwannoma: A Case Study Open
Schwannoma in retroperitoneal region is quite rare. In this report, we presented such a rare case of a large size schwannoma in a 23-year-old man admitted with a complaint of mild pain in his right lower abdomen. The abdominal ultrasonogra…
View article: Exogenous Putrescine Alleviates Drought Stress by Altering Reactive Oxygen Species Scavenging and Biosynthesis of Polyamines in the Seedlings of Cabernet Sauvignon
Exogenous Putrescine Alleviates Drought Stress by Altering Reactive Oxygen Species Scavenging and Biosynthesis of Polyamines in the Seedlings of Cabernet Sauvignon Open
Climate change imposes intensive dry conditions in most grape-growing regions. Drought stress is one of the most devastating abiotic factors threatening grape growth, yield, and fruit quality. In this study, the alleviation effect of exoge…
View article: Ginsenoside Compound K Regulates HIF-1α-Mediated Glycolysis Through Bclaf1 to Inhibit the Proliferation of Human Liver Cancer Cells
Ginsenoside Compound K Regulates HIF-1α-Mediated Glycolysis Through Bclaf1 to Inhibit the Proliferation of Human Liver Cancer Cells Open
This study aimed to demonstrate that ginsenoside compound K (20 (S)-ginsenoside CK; CK) downregulates Bcl-2-associated transcription factor 1 (Bclaf1), which inhibits the hypoxia-inducible factor-1α (HIF-1α)-mediated glycolysis pathway to …
View article: Dynamic monitoring of a migrating and penetrating intracardiac foreign body by echocardiography perioperatively
Dynamic monitoring of a migrating and penetrating intracardiac foreign body by echocardiography perioperatively Open
Backgroud: Cardiac penetrating injuries caused by migrating foreign bodies are rare. The perioperative locating of these foreign bodies is challenging since their location may change with the continuous beat of the heart. Case presentation…