Shan Lin
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View article: Supplementary Data from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Supplementary Data from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML Open
Supplementary Data from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
View article: Supplementary Tables from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Supplementary Tables from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML Open
Supplementary Tables from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
View article: Supplementary Figures from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Supplementary Figures from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML Open
Supplementary Figures from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
View article: A Systematic Literature Review of the Impact of International Baccalaureate System of Mathematics Courses on Student Motivation and Learning Effectiveness for Adolescents in Mainland China
A Systematic Literature Review of the Impact of International Baccalaureate System of Mathematics Courses on Student Motivation and Learning Effectiveness for Adolescents in Mainland China Open
This systematic review examines the impact of different educational systems on students' learning performance in mathematics among middle school students in China. In the current educational climate, an increasing number of adolescents are…
View article: Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia
Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia Open
Riboflavin is a diet-derived vitamin in higher organisms that serves as a precursor for flavin mononucleotide and flavin adenine dinucleotide, key cofactors that participate in oxidoreductase reactions. Here, using proteomic, metabolomic a…
View article: Integrative high-throughput studies to develop novel targets and drugs for the treatment of advanced prostate cancer
Integrative high-throughput studies to develop novel targets and drugs for the treatment of advanced prostate cancer Open
View article: Identifying Targeted Therapies for CBFA2T3::GLIS2 Acute Myeloid Leukemia
Identifying Targeted Therapies for CBFA2T3::GLIS2 Acute Myeloid Leukemia Open
CBFA2T3::GLIS2 fusion positive pediatric acute myeloid leukemia (AML) remains one of the worst prognostic AML subgroups. To uncover innovative targeted therapeutic approaches in this disease subtype we performed genome-scale CRISPR-Cas9 sc…
View article: Natural Turmeric‐Derived Nanovesicles‐Laden Metal‐Polyphenol Hydrogel Synergistically Restores Skin Barrier in Atopic Dermatitis via a Dual‐Repair Strategy
Natural Turmeric‐Derived Nanovesicles‐Laden Metal‐Polyphenol Hydrogel Synergistically Restores Skin Barrier in Atopic Dermatitis via a Dual‐Repair Strategy Open
Skin barrier impairment is critical in the development of atopic dermatitis (AD), increasing vulnerability to external pathogens and disrupting cell metabolism, which leads to inflammatory stress and immune imbalance. In this study, a natu…
View article: UDP-glycosyltransferase PpUGT74F2 is involved in fruit immunity via modulating salicylic acid metabolism
UDP-glycosyltransferase PpUGT74F2 is involved in fruit immunity via modulating salicylic acid metabolism Open
Flesh fruits are essential for human health, but pathogen infection poses a threat to fruit production and postharvest storage. The hormone salicylic acid (SA) and its metabolites, such as sugar conjugates and methyl salicylate (MeSA), pla…
View article: Association of leukocyte telomere length with periodontal attachment loss based on a cross-sectional study
Association of leukocyte telomere length with periodontal attachment loss based on a cross-sectional study Open
This study provides evidence of a positive association between leukocyte telomere length and attachment loss in periodontal health. Our results suggested that LTL may serve as a potential biomarker for periodontal health, emphasizing the i…
View article: PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products
PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products Open
The intestinal epithelium, beyond its role in absorption and digestion, serves as a critical protective mechanical barrier that delineates the luminal contents and the gut microbiota from the lamina propria within resident mucosal immune c…
View article: Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia
Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia Open
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View article: Effectiveness of a BOPPPS Teaching Model in Standardized Training for Nephrology Resident Physicians: A Retrospective Cohort Study
Effectiveness of a BOPPPS Teaching Model in Standardized Training for Nephrology Resident Physicians: A Retrospective Cohort Study Open
Aims/Background Based on Bridge-in, Objective, Pre-assessment, Participatory learning, Post-assessment and Summary (BOPPPS), the teaching model has gained increasing attention in the field of medical education. This study aimed to evaluate…
View article: Lipid metabolism and renal function changes switching from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide therapy in CHB patients
Lipid metabolism and renal function changes switching from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide therapy in CHB patients Open
BACKGROUND Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) are common antiviral treatments for chronic hepatitis B (CHB) patients. The effects of TAF therapy have not been clarified. AIM The study aimed to evaluate the …
View article: The UBE2J2/UBE2K-MARCH5 ubiquitination machinery regulates apoptosis in response to venetoclax in acute myeloid leukemia
The UBE2J2/UBE2K-MARCH5 ubiquitination machinery regulates apoptosis in response to venetoclax in acute myeloid leukemia Open
View article: Tenofovir alafenamide significantly increased serum lipid levels compared with entecavir therapy in chronic hepatitis B virus patients
Tenofovir alafenamide significantly increased serum lipid levels compared with entecavir therapy in chronic hepatitis B virus patients Open
Primary sclerosing cholangitis (PSC) is a chronic and progressive immune-mediated cholangiopathy causing biliary tree inflammation and scarring, leading to liver cirrhosis and end-stage liver disease. Diagnosis of PSC is challenging due to…
View article: Faecal microbiota transplantation from young rats attenuates age‐related sarcopenia revealed by multiomics analysis
Faecal microbiota transplantation from young rats attenuates age‐related sarcopenia revealed by multiomics analysis Open
Background Gut microbiota plays a key role in the development of sarcopenia via the ‘gut‐muscle’ axis, and probiotics‐based therapy might be a strategy for sarcopenia. Fecal microbiota transplantation from young donors (yFMT) has attracted…
View article: P-028 Loss of the m6A methyltransferase METTL5 impairs spermiogenesis and male fertility
P-028 Loss of the m6A methyltransferase METTL5 impairs spermiogenesis and male fertility Open
Study question Whether and how METTL5 regulates germ cell development during spermatogenesis. Summary answer METTL5 is required for spermiogenesis. Loss of METTL5 resulted in teratozoospermia and male infertility via reduced translation of…
View article: Supplementary Table from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Table from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Table from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Data from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Data from An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML Open
CRISPR–Cas9-based genetic screens have successfully identified cell type–dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because most of these screen…
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
View article: Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Open
Supplementary Figure from Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts