Jan Andersson
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View article: Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior
Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior Open
Background High Mobility Group Box 1 (HMGB1) is a nuclear protein that upon extracellular release acts as an alarmin to initiate and amplify inflammation. HMGB1 release from nociceptors contributes to both inflammation and pain; however, t…
View article: LubriShieldTM—A permanent urinary catheter coating that prevents uropathogen biofilm formation in vitro independent of host protein conditioning
LubriShieldTM—A permanent urinary catheter coating that prevents uropathogen biofilm formation in vitro independent of host protein conditioning Open
Catheter-associated urinary tract infection is one of the most common healthcare-associated infections, with biofilm formation playing a key role in its pathogenesis. Indwelling medical devices introduce ideal pathways inside the body for …
View article: A prospective randomised pilot study evaluating the safety of the novel LubriShield™ Foley catheter: a permanently coated indwelling urinary catheter
A prospective randomised pilot study evaluating the safety of the novel LubriShield™ Foley catheter: a permanently coated indwelling urinary catheter Open
Objective: Catheter-associated urinary tract infections (CAUTIs) are prevalent healthcare-associated infections, arising from biofilm-forming bacteria. This may be prevented by coating the catheter with an antifouling substance. The novel …
View article: Läsundervisning för att gynna pojkars läsning
Läsundervisning för att gynna pojkars läsning Open
Vi beskriver samverkansarbetet med att utveckla, genomföra och utvärdera en läsundervisningsmodell för att gynna pojkars läsning i lågstadiet. Vi bygger modellen utifrån intervjuresultat från lärare och pojkar inom ramen för ett ULF-projek…
View article: The Effect of View, Latency, Speed and Performed Task on Remote Vehicle Operators
The Effect of View, Latency, Speed and Performed Task on Remote Vehicle Operators Open
Autonomous vehicles (AVs) are being developed as an alternative to conventional transportation, which comes with great timing as there is a global shortage of skilled commercial drivers. However, the complexity of the driving task is extre…
View article: RAB3GAP2 is a Regulator of Skeletal Muscle Endothelial Cell Proliferation and Associated with Capillary Density
RAB3GAP2 is a Regulator of Skeletal Muscle Endothelial Cell Proliferation and Associated with Capillary Density Open
View article: The effect of latency, speed and task on remote operation of vehicles
The effect of latency, speed and task on remote operation of vehicles Open
Introduction: Although self-driving vehicle technology has been developing rapidly in recent years, there are still many challenges left before full autonomy can possibly be achieved. Remote operation could facilitate the development of au…
View article: Vagus nerve SARS‐CoV‐2 infection and inflammatory reflex dysfunction: Is there a causal relationship?
Vagus nerve SARS‐CoV‐2 infection and inflammatory reflex dysfunction: Is there a causal relationship? Open
Autonomic dysfunction is a clinical hallmark of infection caused by SARS‐CoV‐2, but the underlying mechanisms are unknown. The vagus nerve inflammatory reflex is an important, well‐characterized mechanism for the reflexive suppression of c…
View article: Glycyrrhizic Acid Inhibits High-Mobility Group Box-1 and Homocysteine-Induced Vascular Dysfunction
Glycyrrhizic Acid Inhibits High-Mobility Group Box-1 and Homocysteine-Induced Vascular Dysfunction Open
Hyperhomocysteinemia (HHcy) worsens cardiovascular outcomes by impairing vascular function and promoting chronic inflammation via release of danger-associated molecular patterns, such as high-mobility group box-1 (HMGB-1). Elevated levels …
View article: The effect of latency, speed and task performed on remotely operated vehicles
The effect of latency, speed and task performed on remotely operated vehicles Open
This is a publication from the YRS2023 - 11th Young Researchers Seminar, held from 15 to 17 May 2023 in Lisbon, Portugal, hosted by the Laboratório Nacional de Engenharia Civil – LNEC (National Laboratory for Civil Engineering). (restricte…
View article: The effect of latency, speed and task performed on remotely operated vehicles
The effect of latency, speed and task performed on remotely operated vehicles Open
This is a publication from the YRS2023 - 11th Young Researchers Seminar, held from 15 to 17 May 2023 in Lisbon, Portugal, hosted by the Laboratório Nacional de Engenharia Civil – LNEC (National Laboratory for Civil Engineering). (restricte…
View article: Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Supplementary Tables 1-7 Supplementary Table 1. PCR primers and conditions Supplementary Table 2. List of included diagnoses in each histological subgroup Supplementary Table 3. Associations between published genetic risk variants and risk…
View article: Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Supplementary Tables 1-7 Supplementary Table 1. PCR primers and conditions Supplementary Table 2. List of included diagnoses in each histological subgroup Supplementary Table 3. Associations between published genetic risk variants and risk…
View article: Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Background: Although glioma etiology is poorly understood in general, growing evidence indicates a genetic component. Four large genome-wide association studies (GWAS) have linked common genetic variants with an increased glioma ris…
View article: Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Background: Although glioma etiology is poorly understood in general, growing evidence indicates a genetic component. Four large genome-wide association studies (GWAS) have linked common genetic variants with an increased glioma ris…
View article: High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain
High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain Open
Background Neuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation may present an opportunity for developing novel pain therapies. In preclinical models of ne…
View article: Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm Open
View article: Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm Open
Background. Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2…
View article: HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsis
HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsis Open
View article: HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation
HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation Open
Anemia of inflammation, also known as anemia of chronic disease, is refractory to erythropoietin (EPO) treatment, but the mechanisms underlying the EPO refractory state are unclear. Here, we demonstrate that high mobility group box-1 prote…
View article: Study of the Transcutaneous Auricular Vagus Nerve Stimulation May Advance Outcome in Chronic Pediatric Inflammatory Diseases
Study of the Transcutaneous Auricular Vagus Nerve Stimulation May Advance Outcome in Chronic Pediatric Inflammatory Diseases Open
The recent insight that the immune system is innervated has initiated a search for neural reflex circuits suitable for therapeutic targeting in human inflammatory diseases. The inflammatory reflex, signaling along the vagus system to maint…
View article: The Kiruna seismic event: important insights from the geotechnical model
The Kiruna seismic event: important insights from the geotechnical model Open
Luossavaara-Kiirunavaara Aktiebolag's Kiirunavaara Mine is an iron ore mine located in Sweden's Lapland.On 18 May 2020, a seismic event of moment magnitude (Mw) 4.2, calculated on the Swedish National Seismic Network (SNSN) and internation…
View article: Discovery and validation of a pre-diagnostic latent metabolic biomarker for glioma
Discovery and validation of a pre-diagnostic latent metabolic biomarker for glioma Open
View article: Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation
Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation Open
High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both stimulating and inhibiting innate immunity. As reviewed here, HMGB1 is…
View article: Neurons Are a Primary Driver of Inflammation via Release of HMGB1
Neurons Are a Primary Driver of Inflammation via Release of HMGB1 Open
Recent data show that activation of nociceptive (sensory) nerves turns on localized inflammation within the innervated area in a retrograde manner (antidromically), even in the absence of tissue injury or molecular markers of foreign invad…
View article: De-RISC: Dependable Real-time RISC-V Infrastructure for Safety-critical Space and Avionics Computer Systems
De-RISC: Dependable Real-time RISC-V Infrastructure for Safety-critical Space and Avionics Computer Systems Open
The world market for aviation and space computing systems faces a significant shift caused by the loss of momentum of the traditionally used PowerPC and SPARC instruction set architectures in the commercial domain. This means that the spac…
View article: HMGB1 released from nociceptors mediates inflammation
HMGB1 released from nociceptors mediates inflammation Open
Inflammation, the body’s primary defensive response system to injury and infection, is triggered by molecular signatures of microbes and tissue injury. These molecules also stimulate specialized sensory neurons, termed nociceptors. Activat…
View article: Novel role of PKR in inflammasome activation and HMGB1 release
Novel role of PKR in inflammasome activation and HMGB1 release Open
The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an important role of doub…
View article: De-RISC: Launching RISC-V into space
De-RISC: Launching RISC-V into space Open
An important challenge faced by mission-critical computers is the ability to scale the processing performance, while maintaining a high level of dependability in a harsh environment. The adoption of COTS multi-core processors, as in non-cr…
View article: Redox modifications of cysteine residues regulate the cytokine activity of HMGB1
Redox modifications of cysteine residues regulate the cytokine activity of HMGB1 Open