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View article: Comparative Anatomical and Morphometric Analysis of Eustachian Tube Across Species
Comparative Anatomical and Morphometric Analysis of Eustachian Tube Across Species Open
Background/Objectives: The Eustachian tube (ET) is a physiological channel connecting the middle ear with the external atmosphere. The ET plays a role in maintaining the pressure balance of the middle ear, protecting it from pathogen invas…
View article: Association of triglyceride-glucose index with risk of cardiovascular disease among patients with prediabetes: population based prospective cohort study
Association of triglyceride-glucose index with risk of cardiovascular disease among patients with prediabetes: population based prospective cohort study Open
View article: Immunological Mechanisms and Therapeutic Strategies in Cerebral Ischemia–Reperfusion Injury: From Inflammatory Response to Neurorepair
Immunological Mechanisms and Therapeutic Strategies in Cerebral Ischemia–Reperfusion Injury: From Inflammatory Response to Neurorepair Open
Cerebral ischemia–reperfusion injury (CIRI) is a complex pathological process that arises when blood flow is restored to the brain after ischemia, often resulting in significant neuronal damage and triggering secondary inflammatory respons…
View article: Development of long-acting riluzole transdermal patch against amyotrophic lateral sclerosis: Mechanistic insights into polyglyceryl-3 dioleate-enhanced drug release and skin permeation
Development of long-acting riluzole transdermal patch against amyotrophic lateral sclerosis: Mechanistic insights into polyglyceryl-3 dioleate-enhanced drug release and skin permeation Open
View article: Research progress of anti‑angiogenic therapy combined with immunotherapy and radiotherapy for the treatment of brain metastases in non‑small cell lung cancer (Review)
Research progress of anti‑angiogenic therapy combined with immunotherapy and radiotherapy for the treatment of brain metastases in non‑small cell lung cancer (Review) Open
The treatment of brain metastases (BMs) from non-small cell lung cancer (NSCLC) is primarily systemic and local; however, the therapeutic effects of various treatment methods on BMs are minimal. The occurrence of BMs from NSCLC is a comple…
View article: USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2
USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2 Open
Increasing evidence has implicated the important role of mitochondrial morphofunctional defects in pathological myocardial hypertrophy and heart failure. Deubiquitinating enzymes (DUBs) are involved in protein stability maintenance and reg…
View article: Analysis of the clinical characteristics of five patients with Kawasaki disease complicated with macrophage activation syndrome in Baoding Hospital of Beijing Children’s Hospital, Capital Medical University
Analysis of the clinical characteristics of five patients with Kawasaki disease complicated with macrophage activation syndrome in Baoding Hospital of Beijing Children’s Hospital, Capital Medical University Open
Objective: To investigate clinical characteristics of Kawasaki disease (KD) complicated with macrophage activation syndrome (MAS) and to identify possible indicators for early diagnosis. Method: Clinical data, laboratory indexes, treatment…
View article: Successful treatment of diabetic peripheral neuropathic pain with ultrasound-guided lumbar sympathetic block: A case report
Successful treatment of diabetic peripheral neuropathic pain with ultrasound-guided lumbar sympathetic block: A case report Open
View article: PHYBench: Holistic Evaluation of Physical Perception and Reasoning in Large Language Models
PHYBench: Holistic Evaluation of Physical Perception and Reasoning in Large Language Models Open
Current benchmarks for evaluating the reasoning capabilities of Large Language Models (LLMs) face significant limitations: task oversimplification, data contamination, and flawed evaluation items. These deficiencies necessitate more rigoro…
View article: Structure-based medical acupuncture for greater occipital neuralgia: a case report
Structure-based medical acupuncture for greater occipital neuralgia: a case report Open
Structure-based medical acupuncture could greatly alleviate clinical symptoms in patients with greater occipital neuralgia. Moreover, structure-based medical acupuncture is a safe, accurate, and efficient complementary and alternative trea…
View article: Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia
Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia Open
Pain is a subjective and unpleasant sensation that significantly impacts the daily lives of individuals. Chronic pain represents one of the most challenging public health issues, and ensuring effective pain management is a fundamental righ…
View article: MED26-enriched condensates drive erythropoiesis through modulating transcription pausing
MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open
The Mediator complex regulates various aspects of hematopoietic development, but whether composition of the Mediator complex undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that ME…
View article: Author response: MED26-enriched condensates drive erythropoiesis through modulating transcription pausing
Author response: MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open
View article: MED26-enriched condensates drive erythropoiesis through modulating transcription pausing
MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open
The Mediator complex regulates various aspects of hematopoietic development, but whether composition of the Mediator complex undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that ME…
View article: Primary osteosarcoma of the breast during lactation: a case report and literature review
Primary osteosarcoma of the breast during lactation: a case report and literature review Open
Primary osteosarcoma of the breast (POB) is an aggressive and exceedingly rare tumor, and cases with onset during lactation are extremely rare. The exact mechanism of POB development remains unclear. They may originate from totipotent mese…
View article: Irinotecan plus raltitrexed as second-line treatment in locally advanced or metastatic colorectal cancer patients: a prospective open-label, single-arm, multi-center, phase II study
Irinotecan plus raltitrexed as second-line treatment in locally advanced or metastatic colorectal cancer patients: a prospective open-label, single-arm, multi-center, phase II study Open
View article: MED26-enriched condensates drive erythropoiesis through modulating transcription pausing
MED26-enriched condensates drive erythropoiesis through modulating transcription pausing Open
The Mediator complex regulates various aspects of hematopoietic development, but whether composition of the Mediator complex undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that ME…
View article: Characterization of tongue coating microbiome from patients with colorectal cancer
Characterization of tongue coating microbiome from patients with colorectal cancer Open
These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based bio…
View article: Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15
Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15 Open
Fusobacterium nucleatum ( F. nucleatum ) promotes intestinal tumor growth and its relative abundance varies greatly among patients with CRC, suggesting the presence of unknown, individual-specific effectors in F. nucleatum -dependent carci…
View article: Irinotecan plus raltitrexed as second-line treatment in locally advanced or metastatic colorectal cancer patients: a prospective open-label, single-arm, multicenter, Phase II study
Irinotecan plus raltitrexed as second-line treatment in locally advanced or metastatic colorectal cancer patients: a prospective open-label, single-arm, multicenter, Phase II study Open
Background Colorectal cancer is the third most common cancer and the second leading cause of cancer death. There are limited therapeutic options for the treatment of locally advanced or metastatic colorectal cancers which fail first-line c…
View article: IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin
IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin Open
View article: Electroacupuncture targeting the immune system to alleviate sepsis
Electroacupuncture targeting the immune system to alleviate sepsis Open
Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates. However, options for sepsis are still limited to general treatment in intensive care units (ICUs), and effective therapies that improve sepsis surv…
View article: The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease
The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease Open
Rationale: Ferroptosis-driven loss of dopaminergic neurons plays a pivotal role in the pathogenesis of Parkinson's disease (PD). In PD patients, Hspb1 is commonly observed at abnormally high levels in the substantia nigra. The preci…
View article: Mechanism of Electroacupuncture Mediated Macrophages Infiltration on Dorsal Root Ganglion to Alleviate Paclitaxel-Induced Neuropathic Pain
Mechanism of Electroacupuncture Mediated Macrophages Infiltration on Dorsal Root Ganglion to Alleviate Paclitaxel-Induced Neuropathic Pain Open
View article: Prevalence and clinical implications of polypharmacy and potentially inappropriate medication in elderly patients with heart failure: results of six months' follow-up
Prevalence and clinical implications of polypharmacy and potentially inappropriate medication in elderly patients with heart failure: results of six months' follow-up Open
Polypharmacy and PIM were highly prevalent in elderly patients with HF, and their use was associated with an increased risk of composite endpoint events, readmission and mortality. Non-cardiovascular medications, "PIMs in older adults with…
View article: Retraction notice to “MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury” [Biomed. Pharmacother. 105 (2018) 103–114]
Retraction notice to “MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury” [Biomed. Pharmacother. 105 (2018) 103–114] Open
View article: Mechanism of gastrointestinal injury in COVID-19 and potential use of ghrelin therapy
Mechanism of gastrointestinal injury in COVID-19 and potential use of ghrelin therapy Open
View article: Effectiveness of Multidomain Dormitory Environment and Roommate Intervention for Improving Sleep Quality of Medical College Students: A Cluster Randomised Controlled Trial in China
Effectiveness of Multidomain Dormitory Environment and Roommate Intervention for Improving Sleep Quality of Medical College Students: A Cluster Randomised Controlled Trial in China Open
Medical students are vulnerable to sleep disorders, which could be further exaggerated by poor dormitory environment and roommate behaviour. However, there is little evidence of whether dormitory environment intervention is effective in im…
View article: Long-Term Evolution of Vacancies in Large-Area Graphene
Long-Term Evolution of Vacancies in Large-Area Graphene Open
Devices based on two-dimensional (2D) materials such as graphene and molybdenum disulfide have shown extraordinary potential in physics, nanotechnology, and electronics. The performances of these applications are heavily affected by defect…
View article: Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO
Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO Open
Hepatocellular carcinoma (HCC) is one of the most common primary cancers with limited therapeutic options. Melatonin, a neuroendocrine hormone produced primarily by the pineal gland, demonstrates an anti-cancer effect on a myriad of cancer…