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View article: Atg16l1 and Xbp1 cooperatively protect from transcription-associated mutagenesis and small intestinal carcinogenesis
Atg16l1 and Xbp1 cooperatively protect from transcription-associated mutagenesis and small intestinal carcinogenesis Open
View article: Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy
Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy Open
Metabolomics provides snapshots of states of metabolites under specific conditions, with nuclear magnetic resonance (NMR) being one of the few noninvasive techniques. However, when applied to intact cells (e.g., yeast or mammalian cells) o…
View article: Probing intracellular yeast metabolism with deuterium magnetic resonance spectroscopy
Probing intracellular yeast metabolism with deuterium magnetic resonance spectroscopy Open
Metabolomics provides insights into biochemical dynamics, with nuclear magnetic resonance (NMR) being one of the few noninvasive techniques. However, traditional 1H NMR often suffers from overlapping signals from proteins and numerous meta…
View article: A metabolic constraint in the kynurenine pathway drives mucosal inflammation in IBD
A metabolic constraint in the kynurenine pathway drives mucosal inflammation in IBD Open
Summary Inflammatory bowel disease (IBD) is associated with perturbed metabolism of the essential amino acid tryptophan (Trp). Whether increased degradation of Trp directly fuels mucosal inflammation or acts as a compensatory attempt to re…
View article: Fecal metaproteomics enables functional characterization of remission in patients with inflammatory bowel disease
Fecal metaproteomics enables functional characterization of remission in patients with inflammatory bowel disease Open
Background The gut microbiome is an important contributor to the development and the course of inflammatory bowel disease (IBD). While changes in the gut microbiome composition were observed in response to IBD therapy using biologics, stud…
View article: Decreased Serum Tryptophan and Severe Ulcerative Damage of Colon Mucosa Identify Inflammatory Bowel Disease Patients With High Risk of Cytomegalovirus Colitis
Decreased Serum Tryptophan and Severe Ulcerative Damage of Colon Mucosa Identify Inflammatory Bowel Disease Patients With High Risk of Cytomegalovirus Colitis Open
INTRODUCTION: Patients with inflammatory bowel disease (IBD) are predisposed to the reactivation of viral infections such as cytomegalovirus (CMV). Clinical discrimination of disease flares and colonic CMV reactivation is difficult in pati…
View article: Tryptophan degradation as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases
Tryptophan degradation as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases Open
View article: Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut
Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut Open
View article: P224 JAK-STAT-Driven Tryptophan Degradation Fuels Mucosal Inflammation through QPRT Suppression-Induced Quinolinic Acid Overflow
P224 JAK-STAT-Driven Tryptophan Degradation Fuels Mucosal Inflammation through QPRT Suppression-Induced Quinolinic Acid Overflow Open
Background Inflammatory bowel disease is characterized by disturbed metabolism, including disrupted tryptophan (TRP) metabolism along the kynurenine pathway (KP). However, the molecular mechanism how this fuels inflammation is not understo…
View article: Tryptophan wasting and disease activity as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases
Tryptophan wasting and disease activity as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases Open
Chronic inflammatory diseases (CID) are systems disorders affecting various organs including the intestine, joint and skin. The essential amino acid tryptophan (Trp) is not only used for protein synthesis but can also be catabolized to var…
View article: Fibrosis and Inflammation in Inflammatory Bowel Disease—More Than 2 Sides of the Same Coin?
Fibrosis and Inflammation in Inflammatory Bowel Disease—More Than 2 Sides of the Same Coin? Open
View article: Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut
Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut Open
Inflammatory bowel diseases (IBD) are characterized by chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, th…
View article: Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis
Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis Open
View article: Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice Open