Linan Song
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View article: Safety, Pharmacokinetics and Target Engagement of a Novel Brain Penetrant <scp>RIPK1</scp> Inhibitor (<scp>SIR9900</scp>) in Healthy Adults and Elderly Participants
Safety, Pharmacokinetics and Target Engagement of a Novel Brain Penetrant <span>RIPK1</span> Inhibitor (<span>SIR9900</span>) in Healthy Adults and Elderly Participants Open
Receptor‐interacting serine/threonine kinase 1 (RIPK1) regulates inflammatory signaling and induces apoptosis and necroptosis. Pharmacological inhibition of RIPK1 kinase activity has demonstrated efficacy in animal models of neurodegenerat…
View article: A phase I randomized study to evaluate safety, pharmacokinetics, and pharmacodynamics of SIR2446M, a selective RIPK1 inhibitor, in healthy participants
A phase I randomized study to evaluate safety, pharmacokinetics, and pharmacodynamics of SIR2446M, a selective RIPK1 inhibitor, in healthy participants Open
Activation of receptor‐interacting protein kinase 1 (RIPK1), a broadly expressed serine/threonine protein kinase, by pro‐inflammatory cytokines and pathogens can result in apoptosis, necroptosis, or inflammation. RIPK1 inhibition has been …
View article: Soluble PD-L1 as an early marker of progressive disease on nivolumab
Soluble PD-L1 as an early marker of progressive disease on nivolumab Open
Background Soluble PD-L1 (sPD-L1) has been associated with worse prognosis in numerous solid tumors. We determined sPD-L1 levels before and during nivolumab treatment in two prospective clinical trials of metastatic clear cell renal cell c…
View article: Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration
Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration Open
Objective: We tested the hypothesis that plasma neurofilament light chain (NfL) concentrations identify asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk of disease progression. Methods: B…
View article: Toxin A–Predominant Pathogenic Clostridioides difficile: A Novel Clinical Phenotype
Toxin A–Predominant Pathogenic Clostridioides difficile: A Novel Clinical Phenotype Open
Background Most Clostridioides difficile toxinogenic strains produce both toxins A and B (A+B+), but toxin A–negative, toxin B–positive (A−B+) variants also cause disease. We report the identification of a series of pathogenic clinical C. …
View article: Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI
Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI Open
Class I evidence that blood concentrations of GFAP, tau, and NFL discriminate patients with mTBI with and without neuroimaging findings.
View article: [P3–068]: DEVELOPMENT OF AN ULTRASENSITIVE DIGITAL IMMUNOASSAY FOR THE MEASUREMENT OF LRRK2 IN CEREBROSPINAL FLUID
[P3–068]: DEVELOPMENT OF AN ULTRASENSITIVE DIGITAL IMMUNOASSAY FOR THE MEASUREMENT OF LRRK2 IN CEREBROSPINAL FLUID Open
Parkinson's disease (PD), like other neurological disorders, has been recognized to have a genetic component. Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene are recognized as genetic risk factors for familial PD, and may also r…
View article: Extensional midline framework built with porous polyethylene implant (Medpor) in rhinoplasty
Extensional midline framework built with porous polyethylene implant (Medpor) in rhinoplasty Open
Background : : In East Asians, the main steps of rhinoplasty include the regulation of the nasal tip projection along with dorsal augmentation. A complete septal extension graft and columella strut graft are effective tools for the correct…
View article: Repetitive head impact exposure and later‐life plasma total tau in former National Football League players
Repetitive head impact exposure and later‐life plasma total tau in former National Football League players Open
Introduction Blood protein analysis of total tau (t‐tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined pl…
View article: A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics
A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics Open
View article: Plasma tau in Alzheimer disease
Plasma tau in Alzheimer disease Open
Plasma tau partly reflects AD pathology, but the overlap between normal aging and AD is large, especially in patients without dementia. Despite group-level differences, these results do not support plasma tau as an AD biomarker in individu…
View article: Increases of Plasma Levels of Glial Fibrillary Acidic Protein, Tau, and Amyloid β up to 90 Days after Traumatic Brain Injury
Increases of Plasma Levels of Glial Fibrillary Acidic Protein, Tau, and Amyloid β up to 90 Days after Traumatic Brain Injury Open
Glial fibrillary acidic protein (GFAP), microtubule-associated protein tau, and amyloid β peptide (Aβ42) have been proposed as diagnostic and prognostic biomarkers in traumatic brain injury (TBI). Single molecule array (Simoa) is a novel t…
View article: Plasma β-amyloid in Alzheimer’s disease and vascular disease
Plasma β-amyloid in Alzheimer’s disease and vascular disease Open
Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a cohort of 719 individuals (the Swedish BioFINDER study), includin…
View article: Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool
Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool Open
The currently available diagnostics for Clostridium difficile infection (CDI) have major limitations. Despite mounting evidence that toxin detection is paramount for diagnosis, conventional toxin immunoassays are insufficiently sensitive a…
View article: A fully-automated, six-plex single molecule immunoassay for measuring cytokines in blood
A fully-automated, six-plex single molecule immunoassay for measuring cytokines in blood Open
View article: Differential Immunodetection of Toxin B from Highly Virulent Clostridium difficile BI/NAP-1/027
Differential Immunodetection of Toxin B from Highly Virulent Clostridium difficile BI/NAP-1/027 Open
We developed a simple immunoassay capable of differentially detecting toxin B from highly virulent strains of Clostridium difficile (BI/NAP-1/027) in stool. This assay can simultaneously confirm the presence of in vivo toxin production and…