Explanipedia

A call for a unified and multimodal definition of cellular identity in the enteric nervous system Open

Homa Majd, Andrius Cesiulis, Ryan M. Samuel, Mikayla N Richter, Nicholas Elder , et al. · 2025

Plasticity of enteric neurotransmission varies during day-night cycles and with feeding state Open

Anita J. L. Leembruggen, Gözde Yıldız, Justin P. Hardee, Lincon A. Stamp, Joel C. Bornstein , et al. · 2025

Neuronal activity in the enteric nervous system changes during the 24-h day/night cycle, with increased neuronal function detected at night when mice are feeding and active. However, following an acute fast, neuronal sensitivity becomes mo…

From diversity to disease: unravelling the role of enteric glial cells Open

Sneha Santhosh, Lisa Zanoletti, Lincon A. Stamp, Marlene M. Hao, Gianluca Matteoli · 2024

Enteric glial cells (EGCs) are an essential component of the enteric nervous system (ENS) and play key roles in gastrointestinal development, homeostasis, and disease. Derived from neural crest cells, EGCs undergo complex differentiation p…

A call for a unified and multimodal definition of cellular identity in the enteric nervous system Open

Homa Majd, Andrius Cesiulis, Ryan M. Samuel, Mikayla N Richter, Nicholas Elder , et al. · 2024

Summary The enteric nervous system (ENS) is a tantalizing frontier in neuroscience. With the recent emergence of single cell transcriptomic technologies, this rare and poorly understood tissue has begun to be better characterized in recent…

Development of the aganglionic colon following surgical rescue in a cell therapy model of Hirschsprung disease in rat Open

John B. Furness, Enie Lei, Billie Hunne, Cameron D. Adams, Alan J. Burns , et al. · 2023

Patients with Hirschsprung disease lack enteric ganglia in the distal colon and propulsion of colorectal content is substantially impaired. Proposed stem cell therapies to replace neurons require surgical bypass of the aganglionic bowel du…

Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon Open

Anita J. L. Leembruggen, Yuqing Lu, Haozhe Wang, Volkan Uzungil, Thibault Renoir , et al. · 2023

Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is evidence that Group-I metabotropic glutamate receptors (mGlu1 and mGlu5) have established roles in excitatory neurotransmission and synaptic pla…

A Novel Method for Identifying the Transition Zone in Long-Segment Hirschsprung Disease: Investigating the Muscle Unit to Ganglion Ratio Open

Wendy Yang, Jenny Pham, Sebastian K. King, Donald F. Newgreen, Heather M. Young , et al. · 2022

Hirschsprung disease (HSCR) is characterised by the absence of enteric ganglia along variable lengths of the distal bowel. Current gold standard treatment involves the surgical resection of the defective, aganglionic bowel. Clear and relia…

IL-33 promotes gastric tumour growth in concert with activation and recruitment of inflammatory myeloid cells Open

Chau P. Tran, Michelle Scurr, Louise O’Connor, Jon N. Buzzelli, Garrett Z. Ng , et al. · 2022

Interleukin-33 (IL-33) is an IL-1 family cytokine known to promote T-helper (Th) type 2 immune responses that are often deregulated in gastric cancer (GC). IL-33 is overexpressed in human gastric tumours suggesting a role in driving GC pro…

Development, Diversity, and Neurogenic Capacity of Enteric Glia Open

Werend Boesmans, Amelia Nash, Kinga R. Tasnády, Wendy Yang, Lincon A. Stamp , et al. · 2022

Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the “support” cells of the enteric nervous system, studies over the past 20 years have unveiled a vast array of functions carried out by enteric gl…

Surgical method to prevent early death of neonatal rat pups with Hirschsprung disease, thus permitting development of long-term therapeutic approaches Open

Lincon A. Stamp, Enie Lei, Jamie Jie Mei Liew, Ruslan V. Pustovit, Marlene M. Hao , et al. · 2022

Hirschsprung disease occurs when children are born with no intrinsic nerve cells in varying lengths of the large intestine. In the most severe cases, neurons are also missing from the distal part of the small intestine. Nerve-mediated rela…

Publisher Correction: Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death Open

Caroline S. Hirst, Lincon A. Stamp, Annette J. Bergner, Marlene M. Hao, Mai X. Tran , et al. · 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death Open

Caroline S. Hirst, Lincon A. Stamp, Annette J. Bergner, Marlene M. Hao, Mai X. Tran , et al. · 2017

Goldberg-Shprintzen syndrome is a poorly understood condition characterized by learning difficulties, facial dysmorphism, microcephaly, and Hirschsprung disease. GOSHS is due to recessive mutations in KIAA1279 , which encodes kinesin famil…

Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells Open

Lincon A. Stamp, Rachel M. Gwynne, Jaime P. P. Foong, Alan Lomax, Marlene M. Hao , et al. · 2017

Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System Open

Sonja J. McKeown, Mitra Mohsenipour, Annette J. Bergner, Heather M. Young, Lincon A. Stamp · 2017

Recent advances in regenerative medicine to treat enteric neuropathies: use of human cells Open

Lincon A. Stamp, Heather M. Young · 2016

As current options for treating most enteric neuropathies are either non‐effective or associated with significant ongoing problems, cell therapy is a potential attractive possibility to treat congenital and acquired neuropathies. Studies u…

Table of Contents Open

Keisaku Sato, Chad Hall, Shannon Glaser, Heather Francis, Fanyin Meng , et al. · 2016

A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy Open

Ian A. Parish, Lincon A. Stamp, Ayla May D. Lorenzo, Suzanne M. Fowler, Yovina Sontani , et al. · 2016

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies Open

Alan J. Burns, Allan M. Goldstein, Donald F. Newgreen, Lincon A. Stamp, Karl‐Herbert Schäfer , et al. · 2016

A novel mutation in the nucleoporin NUP35 causes murine degenerative colonic smooth muscle myopathy Open

Ian A. Parish, Lincon A. Stamp, Ayla May D. Lorenzo, Suzanne M. Fowler, Yovina Sontani , et al. · 2016

Chronic Intestinal Pseudo-Obstruction (CIPO) is a rare, but life-threatening, disease characterized by severe intestinal dysmotility. Histopathological studies of CIPO patients have identified several different mechanisms that appear to be…

Enteric Neural Cells From Hirschsprung Disease Patients Form Ganglia in Autologous Aneuronal Colon Open

Ben Rollo, Dongcheng Zhang, Lincon A. Stamp, Trevelyan R. Menheniott, Lefteris Stathopoulos , et al. · 2015

NC-lineage cells can be obtained from HSCR patient colon and can form ENS-like structures in aneuronal colonic muscle from the same patient.

Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model Open

Lincon A. Stamp, Florian Obermayr, Louise Pontell, Heather M. Young, Dan Xie , et al. · 2015

This study provides a novel approach for studying EDNRB signalling in multiple organ systems in mature rats, including an animal model to study the efficacy of cell therapy to treat Hirschsprung disease.

Ion Channel Expression in the Developing Enteric Nervous System Open

Caroline S. Hirst, Jaime P. P. Foong, Lincon A. Stamp, Emily Fegan, Stephan Dent , et al. · 2015

The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunoh…

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