Linda Bussini
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View article: Risk factors for persisting SARS-CoV-2 infection in patients with B-cell malignancies in the Omicron era: A multicenter cohort study
Risk factors for persisting SARS-CoV-2 infection in patients with B-cell malignancies in the Omicron era: A multicenter cohort study Open
View article: Why do echinocandins fail? Identifying key predictors to improve clinical outcomes of candida bloodstream infections: a retrospective multicenter cohort study
Why do echinocandins fail? Identifying key predictors to improve clinical outcomes of candida bloodstream infections: a retrospective multicenter cohort study Open
View article: What Is the Impact of Anti-Enterococcal Empirical Therapy on Survival of Patients With Enterococcal Bloodstream Infections?
What Is the Impact of Anti-Enterococcal Empirical Therapy on Survival of Patients With Enterococcal Bloodstream Infections? Open
Background The impact of early administration of active anti-enterococcal empirical therapy (EET) on outcomes of patients with enterococcal bloodstream infections (EBSIs) is unclear. We compared the outcome of patients with EBSIs receiving…
View article: Role of liposomal amphotericin B in intensive care unit: an expert opinion paper
Role of liposomal amphotericin B in intensive care unit: an expert opinion paper Open
Introduction Invasive fungal infections (IFI) are frequent in patients admitted to the intensive care unit (ICU). The use of first-line antifungals like triazoles or echinocandins may be limited by the global spread of multi-drug resistanc…
View article: P04. Higher risk of invasive fungal infection after RSV infections in allogeneic stem cell transplantation recipients
P04. Higher risk of invasive fungal infection after RSV infections in allogeneic stem cell transplantation recipients Open
Background Allogenic hematopoietic stem cell transplantation (aHSCT) recipients are vulnerable to invasive fungal infections (IFI), a leading cause of morbidity and mortality. While known risk factors exist,1,2 respiratory viral infections…
View article: P06. First-line combination therapy with fifth generation cephalosporins plus daptomycin compared to other-antimicrobial-regimens for methicillin-resistant <i>Staphylococcus aureus</i> bacteraemia: a multicenter retrospective cohort study
P06. First-line combination therapy with fifth generation cephalosporins plus daptomycin compared to other-antimicrobial-regimens for methicillin-resistant <i>Staphylococcus aureus</i> bacteraemia: a multicenter retrospective cohort study Open
Background This study aims to evaluate the effectiveness of 5th-generation-cephalosporins + daptomycin (5GC + DAP) comparedcto other antimicrobial regimens (OAR) for the treatment of methicillin-resistant S. aureus bacteremia (MR-SAB). Met…
View article: Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis From Northern Italy
Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis From Northern Italy Open
Community-onset BSIs demonstrated substantial prevalence of resistant pathogens, including ESBL and MRSA, emphasizing the need for robust surveillance systems. Age is a critical factor in guiding empirical antibiotic therapy in the ED.
View article: Distinct chromosomal mutation associated with cefiderocol resistance in Acinetobacter baumannii: a combined bioinformatics and mass spectrometry approach to unveil and validate the in vivo-acquired chemoresistance
Distinct chromosomal mutation associated with cefiderocol resistance in Acinetobacter baumannii: a combined bioinformatics and mass spectrometry approach to unveil and validate the in vivo-acquired chemoresistance Open
Acinetobacter baumannii is a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant G…
View article: Increase in invasive group A streptococcal infections in Milan, Italy: a genomic and clinical characterization
Increase in invasive group A streptococcal infections in Milan, Italy: a genomic and clinical characterization Open
Background Group A Streptococcus (GAS) causes multiple clinical manifestations, including invasive (iGAS) or even life-threatening (severe-iGAS) infections. After the drop in cases during COVID-19 pandemic, in 2022 a sharp increase of GAS …
View article: Safety and effectiveness of fifth generation cephalosporins for the treatment of methicillin-resistant staphylococcus aureus bloodstream infections: a narrative review exploring past, present, and future
Safety and effectiveness of fifth generation cephalosporins for the treatment of methicillin-resistant staphylococcus aureus bloodstream infections: a narrative review exploring past, present, and future Open
The use of anti-MRSA cephalosporins is an acceptable choice either in monotherapy or combination therapy for the treatment of MRSA-BSIs due to their relevant effectiveness and safety. Particularly, their use may be advisable in combination…
View article: Dual combined antiviral treatment with remdesivir and nirmatrelvir/ritonavir in patients with impaired humoral immunity and persistent SARS‐CoV‐2 infection
Dual combined antiviral treatment with remdesivir and nirmatrelvir/ritonavir in patients with impaired humoral immunity and persistent SARS‐CoV‐2 infection Open
Despite global vaccination efforts, immunocompromized patients remain at high risk for COVID‐19‐associated morbidity. In particular, patients with impaired humoral immunity have shown a high risk of persistent infection. We report a case s…
View article: Identify Drug-Resistant Pathogens in Patients with Community-Acquired Pneumonia
Identify Drug-Resistant Pathogens in Patients with Community-Acquired Pneumonia Open
A substantial increase in broad-spectrum antibiotics as empirical therapy in patients with community-acquired pneumonia (CAP) has occurred over the last 15 years. One of the driving factors leading to that has been some evidence showing an…
View article: POS0576 ANTI-TIF1-Γ POSITIVE DERMATOMYOSITIS WITH SEVERE OROPHARYNGEAL INVOLVEMENT AFTER IMMUNE CHECKPOINT INHIBITORS
POS0576 ANTI-TIF1-Γ POSITIVE DERMATOMYOSITIS WITH SEVERE OROPHARYNGEAL INVOLVEMENT AFTER IMMUNE CHECKPOINT INHIBITORS Open
Background Anti-TIF1-γ antibody is specifically associated with paraneoplastic dermatomyositis (DM) [1], but this serum marker has seldom been reported after cancer immunotherapy. Immune checkpoint inhibitors frequently cause im…
View article: Screening microbiologico esteso nel paziente ematologico con neutropenia febbrile: risultati preliminari di uno studio monocentrico
Screening microbiologico esteso nel paziente ematologico con neutropenia febbrile: risultati preliminari di uno studio monocentrico Open
Not available.
View article: Corrigendum to: “Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study)” Clinical Microbiology and Infection 26 (2020) 1545–1553
Corrigendum to: “Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study)” Clinical Microbiology and Infection 26 (2020) 1545–1553 Open
View article: Outcome of early treatment of <scp>SARS‐CoV</scp>‐2 infection in patients with haematological disorders
Outcome of early treatment of <span>SARS‐CoV</span>‐2 infection in patients with haematological disorders Open
Summary Outcome of early treatment of COVID‐19 with antivirals or anti‐spike monoclonal antibodies (MABs) in patients with haematological malignancies (HM) is unknown. A retrospective study of HM patients treated for mild/moderate COVID‐19…
View article: Relationship Between Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines and Development of Breakthrough Infection in Solid Organ Transplant Recipients: The CONTRAST Cohort
Relationship Between Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines and Development of Breakthrough Infection in Solid Organ Transplant Recipients: The CONTRAST Cohort Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients is associated with poorer antibody response (AbR) compared with non-SOT recipients. However, its impact on the r…
View article: Predictors of clinical evolution of SARS‐CoV‐2 infection in hematological patients: A systematic review and meta‐analysis
Predictors of clinical evolution of SARS‐CoV‐2 infection in hematological patients: A systematic review and meta‐analysis Open
Main aim of this systematic review is to quantify the risk and identify predictors of clinical evolution of SARS‐CoV‐2 in hematological patients compared to different control populations. Two independent reviewers screened the literature a…
View article: Neutralizing monoclonal antibodies for early treatment of hospital‐acquired SARS‐CoV‐2 infection in hematologic patients
Neutralizing monoclonal antibodies for early treatment of hospital‐acquired SARS‐CoV‐2 infection in hematologic patients Open
Efficacy of early treatment with anti‐SARS‐CoV‐2 spike protein monoclonal antibodies (mAbs) for nosocomial SARS‐CoV‐2 infection in hematologic patients is unknown. Retrospective, cohort study conducted in four Italian teaching hospitals. W…
View article: European society of clinical microbiology and infectious diseases guidelines for coronavirus disease 2019: an update on treatment of patients with mild/moderate disease
European society of clinical microbiology and infectious diseases guidelines for coronavirus disease 2019: an update on treatment of patients with mild/moderate disease Open
View article: Diagnosis, management and treatment of nosocomial pneumonia in ICU: a narrative review
Diagnosis, management and treatment of nosocomial pneumonia in ICU: a narrative review Open
Background and Objective: Despite recent advances in prevention, diagnosis, and treatment, hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are overriding among the most life-threatening infections in hospitalize…
View article: Risk factors for persistent enterococcal bacteraemia: a multicentre retrospective study
Risk factors for persistent enterococcal bacteraemia: a multicentre retrospective study Open
View article: Prevalence of COVID-19-Associated Pulmonary Aspergillosis: Critical Review and Conclusions
Prevalence of COVID-19-Associated Pulmonary Aspergillosis: Critical Review and Conclusions Open
First reports of cases and case series of COVID-19-associated pulmonary aspergillosis (CAPA) emerged during the first months of the pandemic. Prevalence rates varied widely due to the fact that CAPA was, and still remains, challenging to d…
View article: Successful Treatment of Bloodstream Infection due to a KPC-Producing Klebsiella Pneumoniae Resistant to Imipenem/Relebactam in a Hematological Patient
Successful Treatment of Bloodstream Infection due to a KPC-Producing Klebsiella Pneumoniae Resistant to Imipenem/Relebactam in a Hematological Patient Open
Novel carbapenem-β-lactamase inhibitor combination, imipenem/relebactam (IMI-REL), has been recently approved for treatment of infections with limited or no alternative treatment options. In this study, we described the emergence of the IM…
View article: Inappropriate use of ivermectin during the COVID-19 pandemic: primum non nocere!
Inappropriate use of ivermectin during the COVID-19 pandemic: primum non nocere! Open
View article: Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis
Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis Open
View article: ESCMID COVID-19 living guidelines: drug treatment and clinical management: author's reply
ESCMID COVID-19 living guidelines: drug treatment and clinical management: author's reply Open
View article: ESCMID COVID-19 living guidelines: drug treatment and clinical management
ESCMID COVID-19 living guidelines: drug treatment and clinical management Open
View article: Cefiderocol treatment for carbapenem-resistant <i>Acinetobacter baumannii</i> infection in the ICU during the COVID-19 pandemic: a multicentre cohort study
Cefiderocol treatment for carbapenem-resistant <i>Acinetobacter baumannii</i> infection in the ICU during the COVID-19 pandemic: a multicentre cohort study Open
Objectives To analyse the impact of cefiderocol use on outcome in patients admitted to the ICU for severe COVID-19 and further diagnosed with carbapenem-resistant Acinetobacter baumannii (CR-Ab) infection. Methods Retrospective multicentre…
View article: Non-fermentative gram-negative bloodstream infection in northern Italy: a multicenter cohort study
Non-fermentative gram-negative bloodstream infection in northern Italy: a multicenter cohort study Open